Protein Alignment Ndae1 and slc4a4a

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_009300017.1
• Gene: slc4a4a / 568631
• ZFINID: ZDB-GENE-060526-274
• Length: 1146
• Species: Danio rerio
• Alignment Length: 1145
• Identity: 514/1145 - (44%)
• Similarity: 711/1145 - (62%)
• Gaps: 128/1145 - (11%)

  Fly    20 DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGG--RRHSQRRRKHHHSGPGGGGGGG 82
            :|||..|  .|.........:.:.|||  ||:|:|||||..  ||...|||..|..
Zfish    40 EDEAVLD--RGASLLKPLCDQEEVEGH--HTIYIGVHVPKSYRRRRRHRRRTSHKD--------- 91

  Fly    83 GGGGSIGGSGSVGGGAGKDNVSEKQQEVERP-VTPPAQRVQFILGEDVDDGTHVSHPLFSEMGML 146
               .....|.:....:..:|..|....:.:| ::|.|:|::|||||  ||.:.....||:|:..|
Zfish    92 ---RKEKVSENTSDRSDAENNEEASNSILKPLISPAAERIRFILGE--DDDSPAPPQLFTELDEL 151

  Fly   147 VK-EGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLE 210
            :. :|.|:|||||||||||||.||:||.|||||||||||||||||||..:..|::|||:||..|.
Zfish   152 LSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHSLFELRTCIEKGTIMLDLEASTLP 216

  Fly   211 VMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADM-RNHSSSKKKKS 274
            .:.:::.|..:.:|.|...:|:||...|||:||||   .||:.|   |||||: :..||:.:..|
Zfish   217 GVVEMITDSQIESGLLKADLKEKVMYTLLRKHRHQ---TKKSNL---RSLADIGKTVSSASRLFS 275

  Fly   275 NSKHSR-PAQNLSSI-------TEDMVKSPSNQSMARPGSGT------------ELSEQQHKG-- 317
            ...::| |.:  ||:       :|::::.|.:.||..|.|.|            ::|::..|.
Zfish   276 TPDNARNPLE--SSVPCLTTRTSEEVLRVPGSPSMGWPSSPTTAHRNLTSSSLNDISDKPEKDQL 338

  Fly   318 NTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQS 382
            ...||:|:|..|||||:||||||||:.....|:||.|||:||.||||||||||:||||||.|...
Zfish   339 KNKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAK 403

  Fly   383 NFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQ 447
            ::||||||:|||||||:|||:||:|:.|..||:|:|||||.|.|||||||||.||||||.::||.
Zfish   404 SYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSS 468

  Fly   448 EVRKRPPELPKEEVDEEEEEARLREENG-----------LSRTGRLFGGLINDIKRKAPWYISDY 501
            :.||.    .....|..:.........|           |.:||:..||||.|:|||.|::.||:
Zfish   469 DKRKN----MYAGGDSTQMNGDTPHSGGHGGGGHAVGDELKKTGKFCGGLILDVKRKVPFFFSDF 529

  Fly   502 KDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTIL 566
            .|:|.:|.:::.:|:|...::..|||||||.:||......:||.:...|.|..:...:||||.||
Zfish   530 YDSLHIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAVTGAVFCLLAGQPLIIL 594

  Fly   567 GSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATL 631
            .|||||||||.:::.|..:..:||:.||.|||:|.|..|:||.|.|||.||.|.||||||.|::|
Zfish   595 SSTGPVLVFERLLFNFSRENDFDYLEFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSL 659

  Fly   632 IAFIFIYKAIENVMVIGKNFPVNQGI-------YDCVCTPPIGSNAS-------------VIDYA 676
            |:|||||.|.:.::.:...:|:|...       |||:|..|..:|:|             .::|.
Zfish   660 ISFIFIYDAFKKMLKLAHYYPINSDFKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYT 724

  Fly   677 -----KYNWDS-----CESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFP 731
                 ...|.|     |..|.|.|||..|...|  ::.|||.:|..||:..|..||:||.:.|||
Zfish   725 TDPRMNATWSSLSKKECLKYGGELVGKACEFVP--DITLMSFILFFGTYTCSMCLKKFKTSPFFP 787

  Fly   732 SIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIA 796
            :.||:.||||::::||......|..:||.|.||.||:|.|||...|||.:||| ..||||..:.|
Zfish   788 TTVRKLISDFAIILAILIFCGVDALVGVETPKLIVPSEFKPTSPNRGWFVPPF-GGNPWWVYLGA 851

  Fly   797 VFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSI 861
            ..||||.|||:|||||||||||||||:|||||.|||||||.:::|:|:||.|||||:|||||:||
Zfish   852 SVPALLVTILLFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISI 916

  Fly   862 NHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGV 926
            .|::|||:|:|.|||||:|:||||||||||.:::|:..|:||.::|:|..||||||:||||||||
Zfish   917 AHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGV 981

  Fly   927 ASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPL 991
            |||.|:||.||:.::.||||:|||.::||.||:::|||||.:||.||.:||::|| :..:|:||:
Zfish   982 ASLNGVQFMDRLKLLLMPAKHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKS-TVAAIIFPV 1045

  Fly   992 MLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHK-------LDAEDNHHQHPPGSGA 1049
            |::.::.:|||||.:|::.:|..|||::||..|:...|:..|       :|::.....:|
Zfish  1046 MILALVAVRKALDYIFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKQGSIDSDMEDSDYP----- 1105

  Fly  1050 GANYNADKSGPTTIHIPLS--------GNKTGTKGPTVNI 1081
               ||   ....:|.||:.        |:|...:..:.:|
Zfish  1106 ---YN---ENVPSIKIPMDMMEQEPFLGDKASDREKSASI 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	459/940 (49%)
		Band_3_cyto	167..435	CDD:284893	146/290 (50%)
		HCO3_cotransp	476..968	CDD:279322	263/521 (50%)
slc4a4a	XP_009300017.1	ae	145..1070	CDD:273290	459/940 (49%)
		Band_3_cyto	173..455	CDD:284893	145/289 (50%)
		HCO3_cotransp	504..1023	CDD:279322	263/521 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575034
Domainoid	1	1.000	95	1.000	Domainoid score	I7342
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.650