DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and slc4a2a

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_005163568.1	Gene:	slc4a2a / 566075	ZFINID:	ZDB-GENE-051101-2	Length:	1247	Species:	Danio rerio

Alignment Length:	1033	Identity:	396/1033 - (38%)
Similarity:	573/1033 - (55%)	Gaps:	95/1033 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGGGGGGGGGSIGGSGSVG--GGAGKDNVS 104
            |.:|.::|..   ..|||.|||..::                     ...|.|.  |...|:..|
Zfish   272 DLDGIKSHRF---EDVPGVRRHLVKK---------------------SAKGQVVHIGKDYKEFSS 312

  Fly   105 EKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPL--FSEMG-MLVKEGDEIEWKETARWIKFEE 166
            ..:.:::|  ||..:|.....   :|...|.:..|  |.|:. :|:.:..|:.||||||||||||
Zfish   313 RIRTKLDR--TPHERRSWPCY---MDHRVHRAQQLKVFVELNELLMDKNQEMHWKETARWIKFEE 372

  Fly   167 DVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVK 231
            ||||...||.|||||:||..||.|||:.:.:|:|:||::.:.|..:|..|.:.|:.:..:....:
Zfish   373 DVEEETERWGKPHVASLSFRSLLELRKTISHGAVLLDLDQKTLPGIAHQVVEQMIISDQIRAHDR 437

  Fly   232 DKVKDALLRRHRH-----QHEYAKK----TRLPIIRSLADMRNHSSSKKKKSNSKHSRPAQNLSS 287
            ..|..|||.:|.|     :|....:    |.|..:.|.....||..:.:..:........:|..|
Zfish   438 ANVLRALLLKHSHPSDGKEHSLFNRNISATSLGSLISHYHSTNHIGAPELPATDPLIGGLRNFES 502

  Fly   288 ITE-DMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIR 351
            .:. |.|:.....|....|    |.:.:.|.....:.|||..|||:.:|||.||||::....|:|
Zfish   503 RSSVDYVEKNEKDSPQFFG----LHKTKSKHELKLLEKIPEDAEATVVLVGCVDFLDQPTMAFVR 563

  Fly   352 LSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSG 416
            |.:||:|..:.|||:|.||:|:|||||.:..::|:|||:::|||||:.|||.||.|..|..||:.
Zfish   564 LKEAVLLESVLEVPIPVRFLFVLLGPPSANIDYHQIGRSISTLMSDKHFHEAAYLADGRQDLLTA 628

  Fly   417 VDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEE--EEARLR-----EEN 474
            ::.|||...||||.|......:...|....:.:.||..:..|.:..|.:  ::..|:     |::
Zfish   629 INSFLDCSIVLPPSEVGGDELLHSIARFQKEMLHKRHEQEVKLQAKEPKSPDDIALQPPLKPEDD 693

  Fly   475 GLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHM 539
            .|.||||||||:|.|::|:.|.||||:|||||.||:|:.||:|||.|||.:||||||.|.|...:
Zfish   694 PLRRTGRLFGGVIRDVRRRYPKYISDFKDALSPQCMATVIFIYFAALSPAVTFGGLLGEKTDGLI 758

  Fly   540 AAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGI 604
            ...|.::|..|.||.:.....|||.|:|.:||:||||...|.||.....:|:|.|.|||||:..|
Zfish   759 GVSELIISTAVQGMLFCLLGAQPLLIVGFSGPLLVFEEAFYSFCKSNDLEYLTGRMWIGMWLIII 823

  Fly   605 CIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNF---PVNQGIYDCVCTPPI 666
            .::..|.:.|.||.:::|||:|.|:.||:.||||   |....:||.|   |:..      |:.|
Zfish   824 VLLTVAFEGSFLVRFVSRFTQEIFSILISLIFIY---ETFFKLGKIFMDHPLRS------CSGP- 878

  Fly   667 GSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFP 731
            ..||:.:....         |.:...|...|....|..|:|:||.:|||.|:..|::|||:.|||
Zfish   879 EENATSLSTGS---------NDSRSTGASQTLNQPNTALLSLVLTSGTFFIAYYLRKFKNSAFFP 934

  Fly   732 SIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKLEVPNELKPTL-STRGWLIPPFVEKN--PWWS 792
            ..:|:.|.||.|.|||..|...|||: ...||||.||:....|. ..|||.|.|.....  |.|.
Zfish   935 GRLRRAIGDFGVPIAISTMVLLDYSIKDTYTQKLNVPDGFSVTSPDKRGWFIHPLGSDGQFPIWM 999

  Fly   793 AIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAAT 857
            ....:.||||..|||||:.|||.:||::||..|.||.|:||||.|:.:...|.::.||||...||
Zfish  1000 MGACILPALLVYILIFMETQITTLIVSKKERMLVKGSGFHLDLLIIVVSGGIAALFGLPWLTGAT 1064

  Fly   858 VLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFL 922
            |.|:.|.|||.:.|:..|||:||:...|:|||||..|:.|.:|:|:::..||..:|:.||||:||
Zfish  1065 VRSVTHANSLTVMSKAVAPGDKPRIQEVKEQRVTGFLVALLVGLSIVIGDLLRQVPIAVLFGIFL 1129

  Fly   923 YMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSI 987
            ||||.||.|:|..:|::::|||.||.||:.::|:|...|:||||.:||.||.:||::.| :..|:
Zfish  1130 YMGVMSLNGIQLTERMMLLFMPPKYHPDHTYVRKVRTLRMHLFTCLQLVCLAVLWIVMS-TAASL 1193

  Fly   988 LFPLMLVVMIGIRK-ALDLVFTRRELKILDDIMPEMTKRAAADDLH-KLDAEDNHHQH 1043
            .||.:||:.:..|: .|..:|:.||::.||           |||.. .||.:|...::
Zfish  1194 AFPFVLVLTVPFRRFLLSRIFSHREIQCLD-----------ADDAEPTLDDKDGQDEY 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	367/901 (41%)
		Band_3_cyto	167..435	CDD:284893	103/277 (37%)
		HCO3_cotransp	476..968	CDD:279322	224/498 (45%)
slc4a2a	XP_005163568.1	ae	345..1246	CDD:273290	375/931 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.680