Protein Alignment Ndae1 and slc4a4b

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_009293410.1
• Gene: slc4a4b / 561618
• ZFINID: ZDB-GENE-091030-1
• Length: 1122
• Species: Danio rerio
• Alignment Length: 1171
• Identity: 522/1171 - (44%)
• Similarity: 708/1171 - (60%)
• Gaps: 147/1171 - (12%)

  Fly     1 MAEKNEYIELPWTMNSSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGG--RRH 63
            |::||:.            :|||..|   .|..:.:...:.:.|||  ||||:||:||..  ||.
Zfish     1 MSDKNKM------------EDEAVVD---RGASYIKNVCDEEVEGH--HTVYIGVNVPKSYRRRR 48

  Fly    64 SQRRRKHHHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERP-VTPPAQRVQFILGE 127
            ..|||..|..            .....:.:|...:..:|..:....:.:| ::|.|:|::|||||
Zfish    49 RHRRRSSHRE------------RRERVTENVSDKSDTENADDSSSSILKPLISPAAERIRFILGE 101

  Fly   128 DVDDGTHVSHPLFSEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFEL 191
            | |.|..... ||:|:. :|..:|.|:|||||||||||||.||:||.||||||||||||||||:|
Zfish   102 D-DSGPPPPQ-LFTELDELLAVDGQELEWKETARWIKFEEKVEKGGERWSKPHVATLSLHSLFQL 164

  Fly   192 RRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPI 256
            :..:..|:::|||:|.:|:.:.:.:.|..:.:|.|...:::.|...|||:||||   .||:.|
Zfish   165 KNCIEKGTIVLDMDANSLQQIVENITDSQIESGQLKADLRETVIYTLLRKHRHQ---TKKSNL-- 224

  Fly   257 IRSLADM--------RNHSSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGT----- 308
             |||||:        |..||.:..:....|:.|........|.|....|| ||....|.|
Zfish   225 -RSLADIGKSVSSASRLFSSQENARGPIDHTVPCFTTFEPEEQMQMQRSN-SMGLLCSPTTAHRN 287

  Fly   309 -------ELSEQQHKG--NTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEV 364
                   :||::..|.  |..||:|||..|||||:||||||||:.....|:||.|:|:||.||||
Zfish   288 LTSTSLNDLSDKPEKDQLNNKFMKKIPRDAEASNVLVGEVDFLDAPFVSFVRLQQSVMLGGLTEV 352

  Fly   365 PVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPP 429
            ||||||:||||||.|...::.|||||:|||||||:||::||:||.|..||:|:|||||.|.||||
Zfish   353 PVPTRFLFILLGPKGKAKSYREIGRAIATLMSDEVFHDIAYKARDRSDLLAGIDEFLDEVIVLPP 417

  Fly   430 GEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEEEEARLREENG------------------- 475
            |||||.||||||.::||.:.||.  .|...|..         :.||
Zfish   418 GEWDPDIRIEPPKSVPSADKRKN--NLAGGEGS---------QMNGGTPHDGGSGGGGGHAVGDE 471

  Fly   476 LSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMA 540
            |..||:..|||:.|||||.|::.||:.|||::|.:::.:|:|...::..|||||||.:||.....
Zfish   472 LKMTGKFCGGLVLDIKRKLPFFASDFYDALNIQSLSAILFIYLGTVTNAITFGGLLGDATENMQG 536

  Fly   541 AMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGIC 605
            .:||.|...:.|..:...:|||||||.|||||||||.:::.|..:..:||:.||.|||:|...:|
Zfish   537 VLESFVGTALTGAVFCLLAGQPLTILSSTGPVLVFERLLFNFSRENAFDYLEFRLWIGLWSGFMC 601

  Fly   606 IVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGI-------YDCVCT 663
            :||.|.|||.||.|.||||||.|:.||:|||||.|.:.::.:..:.|:|.|.       |.|.||
Zfish   602 LVLVATDASFLVQYFTRFTEEGFSALISFIFIYDAFKKMLKLAHHNPINSGYDLELVTQYGCHCT 666

  Fly   664 PPIGSNASVIDYAKY--------------NWDS-----CESYNGTLVGGDCGTPPTENVFLMSVV 709
            ||.| |.|.:...|.              .|.|     |:.:.|.|||..|...|  ::.|||.:
Zfish   667 PPEG-NVSALYLEKMEALMNNTGQHHLNATWASLSRSECQEWGGQLVGATCDFVP--DITLMSFI 728

  Fly   710 LCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTL 774
            |..||:..|..||:||.:.|||:.||:.||||::::||......|..:||.|.||.||:|.|||.
Zfish   729 LFFGTYACSMGLKKFKTSRFFPTTVRKLISDFAIILAILIFCGVDALVGVDTPKLIVPSEFKPTS 793

  Fly   775 STRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILS 839
            ..|||.:.|| ..||||..:.:..||||.|||||||||||||||||||:|||||.|||||||.:|
Zfish   794 PHRGWFVAPF-GGNPWWVYLASFLPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVS 857

  Fly   840 ILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVL 904
            ||:.:||.:||||:|||||:||.|::|||:|:|.|||||:|:||||||||||.|::|:..|:||.
Zfish   858 ILLVVCSFLGLPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGIMVFILTGLSVF 922

  Fly   905 LTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQ 969
            :.|:|..||||||:|||||||||||.|:||.||:.::.||||:|||.::||.||::||||||.||
Zfish   923 MAPVLKFIPMPVLYGVFLYMGVASLNGVQFLDRLELLLMPAKHQPDLIYLRHVPLRRVHLFTFIQ 987

  Fly   970 LACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHK- 1033
            :.||.:||::|| :..:|:||:|::.::.:|||:|.||::.:|..|||:|||..|:...|:..|
Zfish   988 VLCLALLWILKS-TVAAIIFPVMILALVAVRKAMDYVFSQHDLSYLDDVMPEKDKKKKEDEKKKK 1051

  Fly  1034 -----LDAE--------------DNHHQHPPGSGAGANYNADKSGPTTIHIPL--SGNKTGTKGP 1077
                 :|::              |..|..|..:.:..:.|..|.....|.|.|  ..||...|.|
Zfish  1052 KKKGSIDSDMNDEISPCPSSLPTDAKHFFPSRTVSSQDLNPFKKMVPQIRIDLDPDNNKFFWKTP 1116

  Fly  1078 T 1078
            :
Zfish  1117 S 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	460/943 (49%)
		Band_3_cyto	167..435	CDD:284893	141/289 (49%)
		HCO3_cotransp	476..968	CDD:279322	267/517 (52%)
slc4a4b	XP_009293410.1	ae	112..1033	CDD:273290	460/943 (49%)
		Band_3_cyto	140..422	CDD:284893	140/288 (49%)
		HCO3_cotransp	472..986	CDD:279322	267/517 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.660