DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and slc4a11

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_005156613.1	Gene:	slc4a11 / 559346	ZFINID:	ZDB-GENE-090313-183	Length:	877	Species:	Danio rerio

Alignment Length:	1011	Identity:	230/1011 - (22%)
Similarity:	403/1011 - (39%)	Gaps:	228/1011 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QRRRKHHHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDV 129
            ||.|:.|..|                             ||:::|.:....|.        |:|:
Zfish    32 QREREEHEEG-----------------------------SEEREEGQDSPIPS--------GDDI 59

  Fly   130 ---DDGTHVSHPLFSEMGMLVKEGDEIEWKETARWIK---FEEDVEEGGNRWSKPHVATLSLHSL 188
               ...||...|.....|.::       ...:.|::|   |||:|        :.|
Zfish    60 HLYGSQTHQGGPETDVHGCVL-------LNTSRRYVKLMNFEEEV--------RAH--------- 100

  Fly   189 FELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTR 253
            .:|...|...|::|..:..:|:                     |.:|..|  ||..|..:..:..
Zfish   101 RDLDGFLERASILLHEDEASLD---------------------DVLKTML--RHVSQDPHTAEPG 142

  Fly   254 LPIIRSLADMRNHSSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGN 318
            ......::.:...:.|::....|.:.....|:..::|.:      |.:....:|.:..
Zfish   143 CNFEEIMSSLFTDAGSQEVNDRSANFIFYDNVHLLSETL------QCVTATATGIQYQ------- 194

  Fly   319 THFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGD-LTEVPVPTRFVFILLGPPGSQS 382
                       ::...::..|..|:|...|..||.:....|: ..||    |:|.::|.|...:|
Zfish   195 -----------QSWLCILCNVKNLQRRHVCISRLDRPQNWGENCAEV----RYVILILAPSKMKS 244

  Fly   383 --NFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIP 445
              ...|:||..|::.||..|.:....::.:       :||.:|:.:.         |....||
Zfish   245 TKTAMELGRTFASMFSDISFRQKLLESKTQ-------EEFKEALVIQ---------RYHLTAA-- 291

  Fly   446 SQEVRKRPPELPKEEVDEEEEEARLREENGLS------------------RTGRLFGGLINDIKR 492
                :::...:..||.|...::.....|:..|                  |.||   |:..|:.|
Zfish   292 ----KRKTTAVEGEETDPHSQKPLKSAESVFSHLVSLSLLCRGPCCRDFFRVGR---GIYEDLCR 349

  Fly   493 KAPWYISDYKDAL------SMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVC 551
            :.|.|.||:.|.|      .::.:.:.||||.|.|.|.|.||.|..|:|...:...::::...:.
Zfish   350 RLPLYPSDFTDGLVGNNKALVKFMTTSIFLYIAVLLPAIAFGSLNDESTRGEIDVQKTIIGQSIG 414

  Fly   552 GMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASAL 616
            |:.|...:|.||.|..:|.|:.:|.|:|...|.....|:..|...||:|.:...|:....:.|.|
Zfish   415 GIIYSLCAGSPLVIPLTTAPIAIFISVIRGICDDYELDFAAFYACIGLWNSLFLIMGGVFNLSLL 479

  Fly   617 VCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAKYNWD 681
            |....|..||..|..|:..|:..|::..:.|         .:|....|.:.:.::    |:.|..
Zfish   480 VKLFKRSIEEVIALFISIAFVADAVKGTVKI---------FHDNYHAPTLANGSA----AELNRI 531

  Fly   682 SCESYNGTLVGGDCGTPPTENVF--------LMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYI 738
            |...:.|.|...:.|.......|        |:.::|..||..:...|.:|:.:.|....:|:.:
Zfish   532 SGSVHLGELNQTEAGPVSLPESFILCTRARPLLCLLLMMGTLWVGYTLYQFRRSPFLHVKMREIL 596

  Fly   739 SDFSVLIAIFAMSF-------------FDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPW 790
            ||.::.|::...|:             |::..|...|                  :.| ::|...
Zfish   597 SDCALPISVLVFSYVGSYVFNDIALPVFNFHEGPVFQ------------------VAP-LDKLTG 642

  Fly   791 WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVA 855
            .|.:.|:....|..:|||:||.|...:.|..||:|.||..||.||.:..::..:.|::||||..|
Zfish   643 ASVLSAMGLGFLLFLLIFIDQNIVVSLTNAPENRLLKGTAYHWDLTLSGLINILMSVLGLPWMHA 707

  Fly   856 ATVLSINHVNSLKLESECSAPGEKPQ-FLGVREQRVTHILIFLTIGVSVLLTPL-LGNIPMPVLF 918
            |...|..||..|.:..|....|...: .:.|:|.|||.::..:.|||||.|.|: |..||.|||:
Zfish   708 AFPHSTLHVRQLAIVEERVEGGHLYETIVSVKETRVTSLVANILIGVSVFLLPVPLQWIPKPVLY 772

  Fly   919 GVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSF- 982
            |:|||:.:.|::|.|..||:.::.......|...::|:||.:::|.||.:|:..|:.|.....:
Zfish   773 GLFLYIALTSIEGNQMCDRMALLLKEQTSYPPTHYIRKVPQRKIHYFTFLQMVQLLFLCAFGMYP 837

  Fly   983 -SQTSILFPLMLVVMIGIRKA-LDLVFTRRELKILD 1016
             ....::|||::.::|.||.. |..:...:.|.|:|
Zfish   838 LPYMKMIFPLLMFILIPIRNCLLPRIIEAKYLDIMD 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	215/931 (23%)
		Band_3_cyto	167..435	CDD:284893	43/270 (16%)
		HCO3_cotransp	476..968	CDD:279322	147/538 (27%)
slc4a11	XP_005156613.1	PtsN	<208..281	CDD:224676	21/83 (25%)
slc4a11	XP_005156613.1	HCO3_cotransp	338..821	CDD:279322	145/517 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950