Protein Alignment Ndae1 and Slc4a4

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_017176484.1
• Gene: Slc4a4 / 54403
• MGIID: 1927555
• Length: 1131
• Species: Mus musculus
• Alignment Length: 1170
• Identity: 529/1170 - (45%)
• Similarity: 725/1170 - (61%)
• Gaps: 149/1170 - (12%)

  Fly    20 DDEAPKDPRTGGEDFTQQF-TENDFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGGGGGG 83
            :|||..|   .|..|.:.. .|.:.|||  ||:|:|||||...|   |||:|...
Mouse     7 EDEAVLD---RGASFLKHVCDEEEVEGH--HTIYIGVHVPKSYR---RRRRHKRK---------- 53

  Fly    84 GGGSIGG----------SGSVGGGAGKDNVSEKQQEVERP-VTPPAQRVQFILGEDVDDGTHVSH 137
                 .|          |.:....:..:|..|....:.:| ::|.|:|::|||||  :|.:....
Mouse    54 -----AGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGE--EDDSPAPP 111

  Fly   138 PLFSEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVM 201
            .||:|:. :|..:|.|:|||||||||||||.||:||.|||||||||||||||||||..:..||:|
Mouse   112 QLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIM 176

  Fly   202 LDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADM-RN 265
            ||.||.:|..:.:::.||.:..|.|.|.:||||...|||:||||   .||:.|   |||||: :.
Mouse   177 LDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQ---TKKSNL---RSLADIGKT 235

  Fly   266 HSSSKKKKSNSKHSR-PAQN----LSSITED----MVKSPSNQSMARP---------GSGTELSE 312
            .||:.:..||..::| |.:|    |::.|.|    :.::||...::.|         .|..::|:
Mouse   236 VSSASRMFSNPDNARSPLENSVPCLANRTLDDDPRVRRTPSVGWLSSPAMTHRNLTSSSLNDISD 300

  Fly   313 QQHKG--NTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILL 375
            :..|.  ...||:|:|..|||||:||||||||:.....|:||.|||:||.||||||||||:||||
Mouse   301 KPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILL 365

  Fly   376 GPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEP 440
            ||.|...::||||||:|||||||:||::||:|:.|..|::|:|||||.|.|||||||||||||||
Mouse   366 GPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPTIRIEP 430

  Fly   441 PAAIPSQEVRKR----------PPELPKE-------EVDEEEEEARLREENGLSRTGRLFGGLIN 488
            |.::||.:.||.          ..:.|.:       ..|.||          |.||||..||||.
Mouse   431 PKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEE----------LQRTGRFCGGLIK 485

  Fly   489 DIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGM 553
            |||||||::.||:.|||::|.:::.:|:|.|.::..|||||||.:||......:||.:...|.|.
Mouse   486 DIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGA 550

  Fly   554 GYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVC 618
            .:..|:|||||||.|||||||||.:::.|.....:||:.||.|||:|.|.:|:||.|.|||.||.
Mouse   551 IFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHNFDYLEFRLWIGLWSAFMCLVLVATDASFLVQ 615

  Fly   619 YITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGI-------YDCVCTPPIGSNASV---- 672
            |.||||||.|::||:|||||.|.:.::.:...:|:|...       :.|.|.||...|.||
Mouse   616 YFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFKVGYNTHFSCACLPPDPVNLSVSNDT 680

  Fly   673 --------------------IDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLI 717
                                .|:|..:...|..|.|.|||.:|...|  ::.|||.:|..||:..
Mouse   681 TLAPEDLPTISSTDMYHNVTFDWAYLSKKECVKYGGKLVGNNCDFVP--DITLMSFILFLGTYTS 743

  Fly   718 STVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIP 782
            |..:|:||.:.:||:..|:.||||:::::|......|..:||.|.||.||:|.|||...|||.:|
Mouse   744 SMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVP 808

  Fly   783 PFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSM 847
            || ..||||..:.|..||||.|||||||||||||||||||:|||||.|||||||.::||:.:||.
Mouse   809 PF-GGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSF 872

  Fly   848 MGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNI 912
            |.|||:|||||:||.|::|||:|:|.|||||:|:||||||||||..|:|:..|:||.:.|:|..|
Mouse   873 MALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFI 937

  Fly   913 PMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILW 977
            |||||:|||||||||||.|:||.||:.::.||.|:|||:::||.||::||||||.:|:.||.:||
Mouse   938 PMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLW 1002

  Fly   978 LIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHK------LDA 1036
            ::|| :..:|:||:|::.::.:||.:|.:|::.:|..|||::||..|:...|:..|      ||:
Mouse  1003 ILKS-TVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDS 1066

  Fly  1037 EDNHHQHPPGSGAGANYNADKSGPTTIHIPL-------SGNKTGTK-GPTVNIPQEAVNRTAVWQ 1093
             ||..:..|...:.|.::|||       ||.       |..:|..| .|.:.|.:|..:...:|:
Mouse  1067 -DNDDEKDPQHSSNATHHADK-------IPFLESLGLPSPPRTPVKVVPQIRIEREPEDNDYLWR 1123

  Fly  1094  1093
            Mouse  1124  1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	465/945 (49%)
Slc4a4	XP_017176484.1	Band_3_cyto	114..1040	CDD:452680	465/945 (49%)