DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and Slc4a8

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_017450386.1	Gene:	Slc4a8 / 315311	RGDID:	735164	Length:	1092	Species:	Rattus norvegicus

Alignment Length:	1138	Identity:	562/1138 - (49%)
Similarity:	750/1138 - (65%)	Gaps:	92/1138 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPWTMNSSSG-------DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGGRRHSQRR 67
            :|...|...|       |:||..|...........:.:.:.||||  |:||||.:|.||:..:..
  Rat     1 MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHR--TLYVGVRMPLGRQSHRHH 63

  Fly    68 RKH--HHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVD 130
            |.|  .|...||.|.|...|                   |:..|.....| |:||||||||.: :
  Rat    64 RTHGQKHRRRGGRGKGASQG-------------------EEGLEASAHDT-PSQRVQFILGTE-E 107

  Fly   131 DGTHVSHPLFSEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRL 194
            |..||.|.||:|:. :.:|||:|.||||||||:|||||||:||.|||||:|||||||||||||..
  Rat   108 DEEHVPHELFTELDEICMKEGEEAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSC 172

  Fly   195 LVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRS 259
            |:||||:|||.|.::|.::||:.|.......|...|:.||::|||::|.||:|..:...:||:||
  Rat   173 LINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNEKKRNNLIPIVRS 237

  Fly   260 LADMRN-----HSSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNT 319
            .|::..     ||..:..::.|..|.||.||.      ||:..|..    .|..:||    |.:.
  Rat   238 FAEVGKKQSDPHSMDRDGQTVSPQSAPATNLE------VKNGVNCE----HSPVDLS----KADL 288

  Fly   320 HFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNF 384
            |||:|||.||||||:||||||.|:|.:..|:|||.||:|..|||||:||||:||||||.|....:
  Rat   289 HFMKKIPAGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQY 353

  Fly   385 HEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEV 449
            |||||:|||:|:|||||:|||:|::||.||:|:|||||.|||||||||||:||||||..:||||.
  Rat   354 HEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEK 418

  Fly   450 RKRPPELPKEEVDEEEEEARLREENG--LSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVAS 512
            ||. |.:|...:...|.|.. ...:|  |.|||||||||:.|:|||||||.|||:||||:||:||
  Rat   419 RKM-PGVPNGNICHVEPEPH-GGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLAS 481

  Fly   513 WIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFES 577
            ::|||.||:||:|||||||.|||...::|:|||....:.|:.|..|:|||||||||||||||||.
  Rat   482 FLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEK 546

  Fly   578 IIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIE 642
            |:::||......|::.|..||:|.|.:||||.|.|||:|||||||||||.||:||..||||:|||
  Rat   547 ILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIE 611

  Fly   643 NVMVIGKNFPVNQ-------GIYDCVCTPPIGSNASVIDY--------AKYNW-----DSCESYN 687
            .::.:.:.:|::.       .:|.|.|..|...|...:.|        |..||     ..|:..:
  Rat   612 KLIHLAETYPIHMHSQLDHLSLYYCRCALPENPNNHTLQYWKEHSIPTADVNWANLTVSECQEMH 676

  Fly   688 GTLVGGDCG--TPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAM 750
            |..:|..||  .|.|.:|...|.:|...||::|:.||.||.:.:||:.||..:|||:|.:.||.|
  Rat   677 GEFIGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSTVSDFAVFLTIFTM 741

  Fly   751 SFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITA 815
            ...|:.:|||:.||:||:..|||...|||.|.| :..||||:.|.|:.||||.||||||||||||
  Rat   742 VILDFLIGVPSPKLQVPSVFKPTRDDRGWFISP-IGPNPWWTVIAAIIPALLCTILIFMDQQITA 805

  Fly   816 VIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKP 880
            ||:||||:||||||||||||.:::|::.:||:||||||||||||||.||||||||||||||||:|
  Rat   806 VIINRKEHKLKKGCGYHLDLLVVAIMLGVCSLMGLPWFVAATVLSITHVNSLKLESECSAPGEQP 870

  Fly   881 QFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPA 945
            :|||:||||||.::||:.:|.||.:|.:|..||||||:||||||||:||:|:|||||:.:..|||
  Rat   871 KFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPA 935

  Fly   946 KYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRR 1010
            |:|||:::||.||:::|||||::||.||::||:||: |..:|:||:|::.::.:||.:||.|::|
  Rat   936 KHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKA-SPAAIVFPMMVLALVFVRKVMDLCFSKR 999

  Fly  1011 ELKILDDIMPEMTKRAAADDLHKLDAEDNHHQHPPGSGAGANYNADK---SGPTTIHIPLSGNKT 1072
            ||..|||:||| :|:...||..|.:.|:...:.       .:...||   .....:..|...|..
  Rat  1000 ELSWLDDLMPE-SKKKKLDDAKKKEEEEEAEKM-------LDIGGDKFPLESRKLLSSPGKNNSF 1056

  Fly  1073 GTKGPTVNIPQEAVNRTAVWQQINKDGNGISEQ 1105
            ......:||..| :.:|.||:.::.:.....|:
  Rat  1057 RCDPSEINISDE-MPKTTVWKALSINSGNTKEK 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	496/905 (55%)
		Band_3_cyto	167..435	CDD:284893	148/272 (54%)
		HCO3_cotransp	476..968	CDD:279322	291/513 (57%)
Slc4a8	XP_017450386.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335811
Domainoid	1	1.000	581	1.000	Domainoid score	I203
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1018	1.000	Inparanoid score	I265
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm44946
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	LDO	PTHR11453
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810