Protein Alignment Ndae1 and Slc4a5

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_038963258.1
• Gene: Slc4a5 / 297386
• RGDID: 1303009
• Length: 1240
• Species: Rattus norvegicus
• Alignment Length: 1254
• Identity: 515/1254 - (41%)
• Similarity: 721/1254 - (57%)
• Gaps: 206/1254 - (16%)

  Fly    34 FTQQFTENDFEGHRAHTVYVGVHVPGGRRHSQRR--RKHHHSG---------PGG-----GGGGG 82
            :.::..|.||.     ::::|..|||   :|||:  .|.|.||         |..     .|..|
  Rat    58 YRRRHPEQDFP-----SIHIGFPVPG---YSQRKSDSKGHLSGLQRVQWSLQPDKSQQDLAGPDG 114

  Fly    83 GGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMGMLV 147
            ....|:|||...               .:|..:|.|:::|.||||: |:..:.:  ||:||..|.
  Rat   115 IKASSLGGSVDF---------------TKRIRSPAAEQLQDILGEE-DEAPNPT--LFTEMDTLQ 161

  Fly   148 KEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVM 212
            .:||::||||:||||||||.|||||.|||||||:|||||||||||..|..|:|:||:::.:|..:
  Rat   162 HDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQI 226

  Fly   213 ADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSNSK 277
            .|.|.:..:..|.|.|.::::|...|||:||||      |:.||.|||||: ..|.|...:|:::
  Rat   227 IDDVIEKQIEGGLLRPELRERVSYVLLRKHRHQ------TKKPIHRSLADI-GKSVSTTNRSSAR 284

  Fly   278 HSRPAQNLSSITEDM-VKSPSNQSMARPGSGTELSEQQHKGNT-----HFMRKIPPGAEASNILV 336
            .......|...|||: ::..::...........:::..|..||     .||:|||..:||||:||
  Rat   285 SPSAGPTLHHSTEDLRIRQSTSYGHLCHAQSRSMNDISHTPNTDQRKNKFMKKIPKDSEASNVLV 349

  Fly   337 GEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFH 401
            ||||||::....|:||:|:.:||.:|||||||||:||||||.|...:::|||||:||||.|::|.
  Rat   350 GEVDFLDQPFIAFVRLAQSSMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFS 414

  Fly   402 EVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRK--------------- 451
            :|||:||.|:.|::|||||||.|.|||||||||.||||||..:||.:.||
  Rat   415 DVAYKARNREDLIAGVDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSV 479

  Fly   452 ---------------------------RPPELP-KEEVDEEEEEARLREENGLSRTGRLFGGLIN 488
                                       ...|:| ..|:.||           |..|||.||||..
  Rat   480 GRSGASAGGGGSGGGAGGSGAGGGGSGNEAEMPAMHEIGEE-----------LIWTGRFFGGLRL 533

  Fly   489 DIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGM 553
            |:|||.||:.||:.|...:|.:::.:|:|..|::..|||||||.:||..:...|||.:...:.|.
  Rat   534 DVKRKLPWFPSDFYDGFHIQSISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGS 598

  Fly   554 GYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVC 618
            .:..||||||.||.||||:|:||.::::|....|.|||.||.|||:..|..|::|.|.|||.::.
  Rat   599 LFCLFSGQPLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIK 663

  Fly   619 YITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGI-------YDCVCTPPIGSNASVID-- 674
            ||||||||.|:|||:|||||.||:.::...|.:|:|...       |.|.|..|...|.:.::
  Rat   664 YITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDSITTYKCECVAPDTVNTTTVNDS 728

  Fly   675 -----------YAKYN-----WD-----SCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLIS 718
                       |...|     |.     .|.||.|.|:|..|...|  ::.|||.:|..||:.::
  Rat   729 ALLVPNTNMSVYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVP--DLALMSFILFFGTYSMT 791

  Fly   719 TVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPP 783
            ..||:||.:.:||:.||..::|||::.:|......|...|:.|.||.|||.:|||...|||.:.|
  Rat   792 LTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLHVPNVIKPTRPDRGWFVAP 856

  Fly   784 FVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMM 848
            | .|||||....::.||||.||||||||||||||||||||||:|..|||||||.:.||:|:||.|
  Rat   857 F-GKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFM 920

  Fly   849 GLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIP 913
            ||||:|||||:||.|::|||:|:|.|||||:||||||||||||.:::|:..|:||.|.|:|..||
  Rat   921 GLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYIP 985

  Fly   914 MPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWL 978
            ||||:|||||||||||.|:||:||..:..||||:|||:.|||.||::|:||||::|:.||.:||:
  Rat   986 MPVLYGVFLYMGVASLNGIQFWDRCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWI 1050

  Fly   979 IKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAEDNHHQH 1043
            :|| :..:|:||:|::.:|.:|:.|||:|::.:|..:|:|:||..|:.:.....:.:..:|..:.
  Rat  1051 LKS-TMAAIIFPVMILGLIIVRRLLDLIFSQHDLAWIDNILPEKEKKESDRKKRRKEVHENTDKE 1114

  Fly  1044 P---PGSGAGANYNADKSGPTTIHIPLSGNKTGTKGPTVNIPQEAVNRTAVWQQINKDGNGISEQ 1105
            |   |              |:.:.||:.|           ||.:..|      .|:..|.| |..
  Rat  1115 PQFLP--------------PSVVKIPMEG-----------IPSDPQN------GIHCVGRG-SGA 1147

  Fly  1106 LIIPVTLKVRQINGNHAPSSATLSPRLSPMHEADEYSEAPTNSPAHPAGNQQQQQQQINNCKEAA 1170
            |||       :..|::  .:..|..|......|       :.|..||.|..:..|.....
  Rat  1148 LII-------EKGGSY--QNLLLFSRTGQTRVA-------STSCQHPQGPLRTLQHSTRK----- 1191

  Fly  1171 KLDGSCSNNSQISPANITP 1189
            |:       .|:.|.::||
  Rat  1192 KI-------FQLEPLSLTP 1203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	448/954 (47%)
		Band_3_cyto	167..435	CDD:284893	133/273 (49%)
		HCO3_cotransp	476..968	CDD:279322	263/521 (50%)
Slc4a5	XP_038963258.1	Band_3_cyto	154..1108	CDD:421404	453/975 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335799
Domainoid	1	1.000	71	1.000	Domainoid score	I9196
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650