DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ndae1 and SPBC543.05c

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_596793.1	Gene:	SPBC543.05c / 2540261	PomBaseID:	SPBC543.05c	Length:	517	Species:	Schizosaccharomyces pombe

Alignment Length:	557	Identity:	138/557 - (24%)
Similarity:	238/557 - (42%)	Gaps:	81/557 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 LFGG-LINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESL 545
            :||. ::||:|::.|:|.||:.||...:.:.:.:.:||:.|.|.:.|...:...|.......|.|
pombe    11 IFGSEIVNDVKKRLPYYKSDWIDACHYRVLPACLNIYFSNLLPELAFALDMFAKTNNSFGVNEVL 75

  Fly   546 VSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTA 610
            ::..:..:.:...|.|||.|:|.|||:.||...:|:.....|..|..|..||.:|......::..
pombe    76 LASVLGSVVFALLSSQPLCIVGVTGPITVFNYTVYDIMHDRGTPYFPFLCWICLWSMIFHFIIAI 140

  Fly   611 IDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDY 675
            .:....|.:||:|:.|.|...:|||::.|.::                 .:|           |.
pombe   141 ANGVYFVKHITKFSCEIFGLYVAFIYLEKGVQ-----------------VLC-----------DQ 177

  Fly   676 AKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISD 740
            .||.                    ..|.|| |:.:.....::..:......:..|...||..:.|
pombe   178 LKYG--------------------LTNTFL-SITIALLFLMVGWLCDTVGKSSLFSYKVRILLLD 221

  Fly   741 FSVLIAIFAMSFFDYSLG----VPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPAL 801
            :.::.:|...|.|.: :|    |...||......:|||| |.|.|..:  |.|.....:|:..::
pombe   222 YGLVASIIFFSGFQH-IGKMREVSLAKLPTTKAFEPTLS-RSWFIKFW--KIPVGDVFLAIPFSI 282

  Fly   802 LGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGL----------PWFVAA 856
            :.|||.:.|..:::|:.......|.|..|:|.|.|:|.|...:..::|:          |...||
pombe   283 VLTILFYFDHNVSSVMAQDPSFPLTKPAGFHWDFFLLGITTGVSGILGIPAPNGLIPQAPMHTAA 347

  Fly   857 TVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILI-FLTIGVSVLLTPL---LGNIPMPVL 917
              |.:..|:..:.|.|.:   .|.....|.|||.::.:. .:|:|  .:..||   |..||..||
pombe   348 --LCVKRVDYDEDEIEKT---HKEVIDRVVEQRASNFIQGLMTVG--TMTGPLLLVLHQIPQCVL 405

  Fly   918 FGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKR-VHLFTMIQLACLIILWLIKS 981
            .|:|..||.:::.|......::.|....|.......|.....|| |.|:|::||......:.|..
pombe   406 AGLFWVMGFSAIFGNGITQNVIWMLSDRKVVSKNHTLNHCSSKRVVWLYTILQLIGFGATFAITQ 470

  Fly   982 FSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILDD 1017
            ..:.||.||::::::|..|. .:...|...:|:|||:
pombe   471 VDKASIGFPIIILLLIPFRTYCMPKWFLEEDLEILDE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	136/554 (25%)
		Band_3_cyto	167..435	CDD:284893
		HCO3_cotransp	476..968	CDD:279322	124/505 (25%)
SPBC543.05c	NP_596793.1	HCO3_cotransp	12..420	CDD:304903	115/467 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3079
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm47125
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
TreeFam	0	0.000	Not matched by this tool.
	9	8.740