Protein Alignment Ndae1 and Slc4a3

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_058745.2
• Gene: Slc4a3 / 24781
• RGDID: 3712
• Length: 1227
• Species: Rattus norvegicus
• Alignment Length: 1262
• Identity: 412/1262 - (32%)
• Similarity: 599/1262 - (47%)
• Gaps: 297/1262 - (23%)

  Fly     9 ELPWTMNSSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVH---------------VP 58
            :|..|:..|...|...|.|....|..::.::|.|||.|| ||.:...|               .|
  Rat    37 DLGKTLAVSRFGDLISKTPAWDPEKPSRSYSERDFEFHR-HTSHHTHHPLSARLPPPHKLRRLPP 100

  Fly    59 GGRRHSQRRRKHHH-SGPGGGGGGGGGGGSIGGSGSV--GGGAGKDNVSEKQQEVE-----RPVT 115
            ...||::|:||... |.|..           .|:..:  .||||.:...|:::|.|     .||.
  Rat   101 TSARHARRKRKKEKTSAPPS-----------EGTPPIQEEGGAGAEEEEEEEEEEEGESEAEPVE 154

  Fly   116 P----PAQRVQFILGEDVDDGTHVS---------------------------------------- 136
            |    |.|:.:|.:|.|.||...:|
  Rat   155 PPPPGPPQKAKFSIGSDEDDSPGLSIKAPCAKALPSVGLPSDQSPQRSGSSPSPRARASRISTEK 219

  Fly   137 ----------------------------------------------------------------- 136
                                                                             
  Rat   220 SRPWSPSASYDLRERLCPGSALGNPGPEQRVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLV 284

  Fly   137 ---------------------------------HPLFSEMG-MLVKEGDEIEWKETARWIKFEED 167
                                             |.:|.|:. :::....|..|:|||||||||||
  Rat   285 KKPSRIQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEED 349

  Fly   168 VEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKD 232
            |||...||.|||||:||..||.||||.:..|:.:||:|...|..:|.||.:.|:.:..:.|..:.
  Rat   350 VEEETERWGKPHVASLSFRSLLELRRTIAQGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRA 414

  Fly   233 KVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSK-KKKSNSKHSRPAQN----LSSITEDM 292
            .|...||.:|.|.::.......|        ||.|||. .....:.|..|:..    :.::.:|:
  Rat   415 SVLRTLLLKHSHPNDDKDSGFFP--------RNPSSSSVNSVLGNHHPTPSHGPDGAVPTMADDL 471

  Fly   293 VK---------SPSNQSMARPGSGTELSEQQHKGNT-HFMRKIPPGAEASNILVGEVDFLERTLS 347
            .:         ....:.:..||.      ..|:|.: ..:.|||..|||:.:|||.|.|||:..:
  Rat   472 GEPAPLWPHDPDAKEKPLHMPGG------DGHRGKSLKLLEKIPEDAEATVVLVGSVPFLEQPAA 530

  Fly   348 CFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDH 412
            .|:|||:||:|..:.|||||.||:|::|||..:.:::||:||::||||||::|||.||:|..|..
  Rat   531 AFVRLSEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQD 595

  Fly   413 LLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEEEEARLR------ 471
            ||..:.||||...|:||.|.:....:...||...:.:|||      .|.::.:.|...|
  Rat   596 LLGAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKR------REREQTKVEMTTRGGYVAP 654

  Fly   472 ---------------EENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACL 521
                           |::.|.|||.:||||:.|:||:.|.|.||.:|||..||||:.:|:|||.|
  Rat   655 GKELSLEMGGSEATSEDDPLQRTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAAL 719

  Fly   522 SPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKM 586
            ||.|||||||.|.|...|...|.:||..|.|:.:.....|||.::|.:||:||||...::||...
  Rat   720 SPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQ 784

  Fly   587 GWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKN- 650
            ..:|:|.|.|:|:|:....:.|.|.:.|.||.||:.||:|.||.||:.||||:....:..:...
  Rat   785 DLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTEH 849

  Fly   651 -----FPVNQGIYDCVCTPPIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTE--------- 701
                 :|..:.:     .|.:..|:|.:                        ||||
  Rat   850 PLLPFYPPEEAL-----EPGLELNSSAL------------------------PPTEGPPGPRNQP 885

  Fly   702 NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKLE 765
            |..|:|::|..|||||:..|::|:|:.|.....|:.|.||.:.|:|..|...|||: ...||||.
  Rat   886 NTALLSLILMLGTFLIAFFLRKFRNSRFLGGKARRVIGDFGIPISILVMVLVDYSITDTYTQKLT 950

  Fly   766 VPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKK 827
            ||..|..|. ..|.|.|||.....|:  |..:.|..||||..|||||:.||||:||::|..:|.|
  Rat   951 VPTGLSVTSPHKRTWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLK 1015

  Fly   828 GCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTH 892
            |.|:||||.::..|..:|.:.||||..||||.|:.|||:|.:.....|||:|||...|||||||.
  Rat  1016 GSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTG 1080

  Fly   893 ILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQV 957
            :||...:|:|:::..:|..||:.||||:||||||.||.|:|...|:|::|||||:.|:..::.:|
  Rat  1081 VLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIFMPAKHHPEQPYVTKV 1145

  Fly   958 PIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKA-LDLVFTRRELKILD--DIM 1019
            ...|:||||.|||.|:.:||::|| :..|:.||.:|::.:.:|:. |..:|..|||:.||  |..
  Rat  1146 KTWRMHLFTFIQLGCIALLWVVKS-TVASLAFPFLLLLTVPLRRCLLPRLFQDRELQALDSEDAE 1209

  Fly  1020 PEMTKRAAADDLHKLDAEDNHHQ-HPP 1045
            |...:          |.:|.::: |.|
  Rat  1210 PNFDE----------DGQDEYNELHMP 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	360/932 (39%)
		Band_3_cyto	167..435	CDD:284893	105/282 (37%)
		HCO3_cotransp	476..968	CDD:279322	214/510 (42%)
Slc4a3	NP_058745.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..255		43/229 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..312		0/25 (0%)
		ae	321..1226	CDD:273290	367/964 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..497		11/82 (13%)
		Membrane (anion exchange)	708..1227		220/559 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650