back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and Slc4a2

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_058744.1	Gene:	Slc4a2 / 24780	RGDID:	3711	Length:	1234	Species:	Rattus norvegicus

Alignment Length:	1055	Identity:	396/1055 - (37%)
Similarity:	587/1055 - (55%)	Gaps:	96/1055 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MNSSSGDDEA--PKDPRTGGEDFTQQFTEND-FEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGP 75
            :.|.:|.::|  |:.|....|..|....:.| .:.||..      .|||.|||..|:
  Rat   238 IGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFE------DVPGVRRHLVRK-------- 288

  Fly    76 GGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLF 140
                         ...||          ::..:|...|...|..|.:         ..|..|.:|
  Rat   289 -------------NAKGS----------TQAAREGREPGPTPRARPR---------APHKPHEVF 321

  Fly   141 SEMGML-VKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204
            .|:..| :.:..|.:|:||||||||||||||...||.|||||:||..||.||||.|.:|:|:||:
  Rat   322 VELNELQLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDL 386

  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLP---IIRSLADMRNH 266
            :.|.|..:|..|.:.||.:..:....:..|..|||.:|.|..: .|:...|   ...||..:..|
  Rat   387 DQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD-EKEFSFPRNISAGSLGSLLGH 450

  Fly   267 SSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEA 331
            ..::..:|:...:.|.  :..:.|..::....:.:..|.....::..:.|.....:.|||..|||
  Rat   451 HHAQGTESDPHVTEPL--IGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEA 513

  Fly   332 SNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMS 396
            :.:|||.|:||.|....|:||.:||.|..:.|||||.||:|:||||..:..::|||||:::||||
  Rat   514 TVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 578

  Fly   397 DEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKR-------PP 454
            |:.|||.||.|.:||.||:.::.|||...||||.|......:...|....|.::||       ||
  Rat   579 DKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPP 643

  Fly   455 EL---PKEEVD----EEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVAS 512
            ..   ||...|    :..|.|...|::.|.||||.|||||.|::|:.|.|:||::|||..||:|:
  Rat   644 GAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAA 708

  Fly   513 WIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFES 577
            .||:|||.|||.|||||||.|.|...:...|.::|..:.|:.:.....|||.::|.:||:||||.
  Rat   709 VIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEE 773

  Fly   578 IIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIE 642
            ..:.||.....:|:..|.|||.|:..:.:::.|::.|.||.:::|||:|.||.||:.||||:...
  Rat   774 AFFSFCKSNQLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFY 838

  Fly   643 NVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAKYN--W--DSCESYNGTLVGGD--CGTPPTE 701
            .::.|.:..|    ::.|..     ||.|..|.:..|  |  .:....|.:..|.:  .|.|
  Rat   839 KLIKIFQEHP----LHGCSV-----SNDSEADSSSNNMTWAATTLAPDNSSASGQERPRGQP--- 891

  Fly   702 NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKLE 765
            |..|:|:||.||||.|:..|::|||:.|||..:|:.|.||.|.|||..|...|||: ...||||.
  Rat   892 NTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLS 956

  Fly   766 VPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKK 827
            ||:....|. ..|||:|.|..||.|:  |..:.::.||:|..|||||:.|||.:|:::||..|:|
  Rat   957 VPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQK 1021

  Fly   828 GCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTH 892
            |.|:||||.::..:..||::.||||..||||.|:.|.|:|.:.|:..|||:||:...|:|||||.
  Rat  1022 GSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTG 1086

  Fly   893 ILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQV 957
            :|:.|.:|:|:::..||..||:.||||:||||||.||.|:||::|:.::.||.|:.||..::::|
  Rat  1087 LLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKV 1151

  Fly   958 PIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILD--DIM 1019
            ...|:||||.:||.||.:||.:.| :..|:.||.:|::.:.:|. .|..:||.||:|.||  :..
  Rat  1152 RTMRMHLFTALQLLCLALLWAVMS-TAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAE 1215

  Fly  1020 PEMTKRAAADDLHKL 1034
            |...:....|:.:::
  Rat  1216 PVFDECEGVDEYNEM 1230

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.