DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and Slc4a1

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_036783.2	Gene:	Slc4a1 / 24779	RGDID:	3710	Length:	928	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	343/966 - (35%)
Similarity:	524/966 - (54%)	Gaps:	111/966 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMG------MLVKEGDEIEWKETARW 161
            |:|.|:....|....|.       :.:...|..|||..|::.      |:.:...|::|.|.|.|
  Rat    38 VTEMQESEALPTEQTAT-------DYIPTSTSTSHPSSSQVYVELQELMMDQRNQELQWVEAAHW 95

  Fly   162 IKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTL 226
            |..||::.|.| .|.:||::.|:..||.||:::...|:.:||:...:|..:|:.:.|..:....:
  Rat    96 IGLEENLREDG-VWGRPHLSYLTFWSLLELQKVFSKGTFLLDLAETSLAGVANKLLDSFIYEDQI 159

  Fly   227 PPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSNSKHSRPAQNLSSITED 291
            .|..:|::..|||.:..|..:            |.|:.....:...:|.:    |::.|
  Rat   160 RPQDRDELLRALLLKRSHAED------------LKDLEGVKPAVLTRSGA----PSEPL------ 202

  Fly   292 MVKSPSNQS---MARPGSGTELSEQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLS 353
            :...||.::   .|:...|:|  |....|    :.||||.:|.:.:|||...||.:.:..|:||.
  Rat   203 LPHQPSLETKLYCAQAEGGSE--EPSPSG----ILKIPPNSETTLVLVGRASFLVKPVLGFVRLK 261

  Fly   354 QAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVD 418
            :||.|.||. :|.|..|:.:||||.....::.::|||.||||::.:|...|..|:.|..|||.:|
  Rat   262 EAVPLEDLV-LPEPVSFLLVLLGPEAPHIDYTQLGRAAATLMTERVFRVTASLAQSRGELLSSLD 325

  Fly   419 EFLDAVTVLPPGEWDPTIRIEPPA------AIPSQEVRKRPPELPK---------EEVDEEEEEA 468
            .|||...||||        .|.|:      .:|.|:...|...||:         |.:.:..:|.
  Rat   326 SFLDCSLVLPP--------TEAPSEKALLNLVPVQKELLRKRYLPRPAKPDPNLYEALADGGKEG 382

  Fly   469 RLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAE 533
            ...|::.|.||||:|||||.||:|:.|:|:||..||||.|.:|:.||:|||.|||.:||||||.|
  Rat   383 PGDEDDPLRRTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVIFIYFAALSPAVTFGGLLGE 447

  Fly   534 ATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIG 598
            .|...|...|.|:|..|.|:.:.....|||.:||.:||:||||...|.||.....:|:..|.|||
  Rat   448 KTRNLMGVSELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAFYSFCESNNLEYIVGRAWIG 512

  Fly   599 MWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCT 663
            .|:..:.:::.|.:.|.||.||:|:|:|.|:.||:.||||:....::.|.:::|:.:.....|..
  Rat   513 FWLILLVVLVVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKLIKIFQDYPLQESYAPVVMK 577

  Fly   664 P-PIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNA 727
            | |.|                               |..|..|:|:||..||||::.:|::|||:
  Rat   578 PKPQG-------------------------------PVPNTALLSLVLMVGTFLLAMMLRKFKNS 611

  Fly   728 LFFPSIVRQYISDFSVLIAIFAMSFFD-YSLGVPTQKLEVPNELK-PTLSTRGWLIPPFVEKN-- 788
            .:||..:|:.|.||.|.|:|..|...| :.....||||.||:.|| ...|.|||:|.|....|
  Rat   612 TYFPGKLRRVIGDFGVPISILIMVLVDTFIKNTYTQKLSVPDGLKVSNSSARGWVIHPLGLYNHF 676

  Fly   789 PWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWF 853
            |.|....:|.||||..||||::.|||.:||::.|.|:.||.|:||||.::..:..:.::.|:||.
  Rat   677 PKWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLDLLLVVGMGGVAALFGMPWL 741

  Fly   854 VAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLF 918
            .|.||.|:.|.|:|.:..:.|.||...|...|:|||::.:|:.:.:|:|:|:.|:|..||:.|||
  Rat   742 SATTVRSVTHANALTVMGKASGPGAAAQIQEVKEQRISGLLVSVLVGLSILMEPILSRIPLAVLF 806

  Fly   919 GVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFS 983
            |:|||||:.||.|:|.|||||::|.|.||.||..|:::|...|:||||.||:.||.:||::|| :
  Rat   807 GIFLYMGITSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKS-T 870

  Fly   984 QTSILFPLMLVVMIGIRK-ALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAED 1038
            ..|:..|.:|::.:.:|: .|.|:|...||:.||....::|    .|:...||..|
  Rat   871 PASLALPFVLILTVPLRRLLLPLIFRELELQCLDGDDAKVT----FDEAEGLDEYD 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	327/905 (36%)
		Band_3_cyto	167..435	CDD:284893	81/270 (30%)
		HCO3_cotransp	476..968	CDD:279322	209/496 (42%)
Slc4a1	NP_036783.2	Globular. /evidence=ECO:0000250	69..303		75/263 (29%)
		ae	72..927	CDD:273290	333/925 (36%)
		Band_3_cyto	100..342	CDD:284893	84/279 (30%)
		Interaction with ANK1. /evidence=ECO:0000250	190..199		1/12 (8%)
		Dimerization arm. /evidence=ECO:0000250	317..370		19/60 (32%)
		HCO3_cotransp	390..856	CDD:279322	209/496 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650