DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and Slc4a9

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_006525969.1	Gene:	Slc4a9 / 240215	MGIID:	2443384	Length:	953	Species:	Mus musculus

Alignment Length:	1052	Identity:	417/1052 - (39%)
Similarity:	582/1052 - (55%)	Gaps:	160/1052 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ENDFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVS 104
            :.|||...||                  ...|...|..|.|.|.|         :.|.:|.| :.
Mouse     6 QGDFESSDAH------------------ENAHSEEPDSGLGPGPG---------LNGPSGID-IG 42

  Fly   105 EKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMGMLVKEGDEIEWKETARWIKFEEDVE 169
            |.|...: |:                        ||.::..|:.....:||:||.||:.|||.::
Mouse    43 ESQVSKD-PL------------------------LFIQLNELLGWPQALEWRETGRWLLFEEKLD 82

  Fly   170 EGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKV 234
            .|..|||.|||.||.|.||.:||.||..|.|:||.:||:|   .:|| :.:||..:|.|.::.::
Mouse    83 MGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSL---LELV-EQVVSGESLSPELRGQL 143

  Fly   235 KDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQ 299
            :..||:|.:|.           |:::.......|:..:|::.....|.::         ::|..|
Mouse   144 QALLLQRPQHH-----------IQTMGIRPCRESNAFRKASRDEDAPLKH---------QNPLRQ 188

  Fly   300 SMARPGSGTELSEQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEV 364
                                    |:|.||||:.:|.||:.|||:.|..|:||...:||..|||:
Mouse   189 ------------------------KLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEM 229

  Fly   365 PVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPP 429
            .:|:||..:|||||....::||:|||.|.|:||..|.....||.....||:.:|.||..||.|||
Mouse   230 ILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPP 294

  Fly   430 GEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEEEEARLREEN----------GLSRTGRLFG 484
            |.||.|.||.||..:|||  .||.|...:|......:.|.|.|:.          .|.|||||||
Mouse   295 GRWDRTARIPPPKYLPSQ--HKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFG 357

  Fly   485 GLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGF 549
            |||.|::|||.||.||:.|||..||.::..::|.|.::..|||||||.:||......:||.:...
Mouse   358 GLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTA 422

  Fly   550 VCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDAS 614
            |.|..:...:|||||||.|||||||||.:::.|......||:.||.|:|:||...|:.|.|.:||
Mouse   423 VAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEAS 487

  Fly   615 ALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQ---GIYDCVCT-PPIGSNASVIDY 675
            .||.|.||||||.|..||:.||||.|:..::.:.:.:|:.:   ..|.|.|. |..|.|.|
Mouse   488 LLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTS---- 548

  Fly   676 AKYNWDS--------------------------CESYNGTLVGGDCGTPPTENVFLMSVVLCAGT 714
               .|.|                          |....|..:|..|.|.|  ::...|::|...:
Mouse   549 ---EWTSAKLKDTEDILSVQPGLVNASFLPPPECIRQGGHPLGPSCHTVP--DIAFFSLLLFFTS 608

  Fly   715 FLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGW 779
            ||.:..||..||:.||||:||:.:.|||.::||......|..||:.|.||.||.|.|||||.|||
Mouse   609 FLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGW 673

  Fly   780 LIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAI 844
            |:.|| ..||||.::.|..||||.:|||||||||||||:||.|.:|:||.|:|||||.:::|:..
Mouse   674 LVSPF-GANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLF 737

  Fly   845 CSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLL 909
            .|.:||||:|:|||:|:.|::||:.||:...|||.|.|||:||||:|.:::|:..|||:.|.|:|
Mouse   738 TSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVL 802

  Fly   910 GNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLI 974
            ..||||||:|:|||||||:|..:||..|:.::.||.|:|||.:.||.||:.||||||.||||||.
Mouse   803 KFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLG 867

  Fly   975 ILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTK-----RAAADDLHK- 1033
            :||::|| :..:|:|||||:.::.|||||:.||:.:||..||::|||..:     |:..:.|..
Mouse   868 LLWVVKS-TPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSG 931

  Fly  1034 LDAEDNHHQHPP 1045
            .|:||:...:.|
Mouse   932 NDSEDSELMYQP 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	388/915 (42%)
		Band_3_cyto	167..435	CDD:284893	93/267 (35%)
		HCO3_cotransp	476..968	CDD:279322	244/521 (47%)
Slc4a9	XP_006525969.1	Band_3_cyto	53..908	CDD:391624	388/915 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750