Protein Alignment Ndae1 and Slc4a5

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_006506026.1
• Gene: Slc4a5 / 232156
• MGIID: 2443220
• Length: 1272
• Species: Mus musculus
• Alignment Length: 1287
• Identity: 497/1287 - (38%)
• Similarity: 700/1287 - (54%)
• Gaps: 282/1287 - (21%)

  Fly    20 DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGGRRHSQRR--RKHHHSG-------- 74
            |:|.....:.....:.::..|.||.     ::::|..||.   :|||:  .|.|.||
Mouse     4 DEEKAGVKKLDPTSYKRRQPEQDFP-----SIHIGFPVPS---YSQRKSDSKGHLSGLQKVQWSL 60

  Fly    75 -PGGG----GGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTH 134
             ||..    .|.|....|.||:...               .:|..:|.|:::|.||||: |:..:
Mouse    61 KPGKPQQELAGPGIRASSQGGAVDF---------------TKRTRSPAAEQLQDILGEE-DEAPN 109

  Fly   135 VSHPLFSEMGMLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGS 199
            .:  ||:||..|..:||::||||:||||||||.|||||.|||||||:|||||||||||..|..|:
Mouse   110 PT--LFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGT 172

  Fly   200 VMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMR 264
            |:||:::.:|..:.|.|.:..:..|.|.|.::::|...|||:||||      |:.||.|||||:
Mouse   173 VLLDLDSCSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRKHRHQ------TKKPIHRSLADI- 230

  Fly   265 NHSSSKKKKSNSKHSRPAQNLSSITEDM-VKSPSNQSMARPGSGTELSEQQHKGNT-----HFMR 323
            ..|.|...:|:::.|.....|...|||: ::..::...........:::..|..||     .||:
Mouse   231 GKSVSTTNRSSARSSSAGPTLHRSTEDLRIRQSTSYGHLCHAQSRSMNDISHTPNTDQRKNKFMK 295

  Fly   324 KIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIG 388
            |||..:||||:||||||||::....|:||.|:.:||.:|||||||||:||||||.|...:::|||
Mouse   296 KIPKDSEASNVLVGEVDFLDQPFIAFVRLVQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIG 360

  Fly   389 RAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKR- 452
            ||:||||.|::|.:|||:||.|:.|::|:|||||.|.|||||||||.||||||..:||.:.||.
Mouse   361 RAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSV 425

  Fly   453 -----------------------------------------PPELP-KEEVDEE----------- 464
                                                     ..|:| ..|:.||
Mouse   426 FSLAEPGQMNGSVGGGGASAGGGGSGGGAGGSGAGGVGSGDEAEMPAMHEIGEELIWTGRCPLHT 490

  Fly   465 ----------------------------------------------------EEEARL---REE- 473
                                                                |...|:   |:|
Mouse   491 WQRACCPEPFLLPVLLAILSLLCAAPLRDGDLTTAVVPHSSESCGSDRIVWGEMNRRIPPVRKEP 555

  Fly   474 ----------------NGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLS 522
                            |.:|: .|.||||..|:|||.||:.||:.|...:|.:::.:|:|..|::
Mouse   556 KHFSRHSLVIVSYSGRNNVSQ-ARFFGGLCLDVKRKLPWFPSDFYDGFHLQSISAVLFIYLGCIT 619

  Fly   523 PIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMG 587
            ..|||||||.:||..:...|||.:...:.|..:..||||||.||.||||:|:||.::::|....|
Mouse   620 NAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKANG 684

  Fly   588 WDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFP 652
            .|||.||.|||:..|..|::|.|.|||.::.||||||||.|:|||:|||||.||:.::...|.:|
Mouse   685 LDYMEFRLWIGLHSAIQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYP 749

  Fly   653 VNQGI-------YDCVC-------------------------------TPPIGS----------- 668
            :|...       |.|.|                               .|.|.|
Mouse   750 INTDFKPDFITTYKCECVAPDTDGGGRREGFIDENWTSSLSAAWAGIMAPSISSETLVNTTTVNA 814

  Fly   669 ----------------NASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLI 717
                            |.:.:|::..:...|.||.|.|:|..|...|  ::.|||.:|..||:.:
Mouse   815 SAPLAPNTNTSLYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVP--DLALMSFILFFGTYSM 877

  Fly   718 STVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIP 782
            :..||:||.:.:||:.||..::|||::.:|......|...|:.|.||.||:.:|||...|||.:.
Mouse   878 TLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLHVPSVIKPTRPDRGWFVA 942

  Fly   783 PFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSM 847
            || .|||||....::.||||.||||||||||||||||||||||:|..|||||||.:.||:|:||.
Mouse   943 PF-GKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSF 1006

  Fly   848 MGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNI 912
            .||||:|||||:||.|::|||:|:|.|||||:||||||||||||.:::|:..|:||.|.|:|..|
Mouse  1007 TGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYI 1071

  Fly   913 PMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILW 977
            |||||:|||||||||||.|:||::|..:..||||:|||:.|||.||::|:||||::|:.||.:||
Mouse  1072 PMPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLW 1136

  Fly   978 LIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAEDNHHQ 1042
            ::|| :..:|:||:|::.:|.:|:.|||:|::.:|..:|:|:||..|:..  |..|...::.|.
Mouse  1137 ILKS-TMAAIIFPVMILGLIIVRRLLDLIFSQHDLAWIDNILPEKDKKET--DKKKKRRKEVHE- 1197

  Fly  1043 HPPGSGAGANYNADKS-------GPTTIHIPLSGNKTGTKGPTVNIPQEAVN 1087
                       .|:|.       .|:.:.||:.|           ||.:..|
Mouse  1198 -----------TAEKEVAMPQFLPPSVVKIPMEG-----------IPSDPQN 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	448/1072 (42%)
		Band_3_cyto	167..435	CDD:284893	133/273 (49%)
		HCO3_cotransp	476..968	CDD:279322	258/556 (46%)
Slc4a5	XP_006506026.1	Band_3_cyto	113..1174	CDD:391624	448/1072 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650