DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and Slc4a7

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_006518061.1	Gene:	Slc4a7 / 218756	MGIID:	2443878	Length:	1274	Species:	Mus musculus

Alignment Length:	1320	Identity:	581/1320 - (44%)
Similarity:	778/1320 - (58%)	Gaps:	257/1320 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVP----GGRRHSQRRRKHHHSGPGGGGG 80
            |:||..|..........:|.:.:.|.|||  ||||||||    ..|||..|..||||.
Mouse    19 DEEAVVDLGKTSSTVNTKFEKEELESHRA--VYVGVHVPFSKESRRRHKHRGHKHHHR------- 74

  Fly    81 GGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERP-VTPPAQRVQFILGEDVDDGTHVSHPLFSEMG 144
                             ..||..|:|:...|.| ...|:||||||||.:.||..|:.|.||:||.
Mouse    75 -----------------RRKDKDSDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMD 122

  Fly   145 ML-VKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQN 208
            .| .::|:|.||||||||:|||||||:||:|||||:|||||||||||||..::||:|||||.|..
Mouse   123 ELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRAST 187

  Fly   209 LEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADM-RNHSSSKKK 272
            |:.:||:|.|:|:::|.|...:::.|::|||:||.||:|....:|:|::||.||: :.||.....
Mouse   188 LDEIADMVLDNMIASGQLDDSIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLL 252

  Fly   273 KSN------SKHS----RPAQNLSSITEDMVK------SPSNQS---------------MARPGS 306
            :.|      |:||    ..|.|||...|..:.      .||:::               .:.|.|
Mouse   253 ERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLSHLLPSSRAGTPAGSRCTTPVPTPQSSPPS 317

  Fly   307 GTELS--------------------------------------------EQQHKGNT-------- 319
            ..:||                                            ||:::.||
Mouse   318 SPDLSRLASRSFQQTQPQAPEVLVSPDRDDIPRVVIHPPEEDIEALKGQEQKNEENTAFTPGILA 382

  Fly   320 ----------------------------------------------------------HFMRKIP 326
                                                                      :||||||
Mouse   383 SPQSAPGNLDNSKSGEMKGNGSGGSRENSTVDFSKESASWHCSCGTLGVGLKKPAVDMNFMRKIP 447

  Fly   327 PGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAM 391
            .||||||:||||||||||.:..|:||:.||:|..||||||||||:|:||||.|....:|||||::
Mouse   448 TGAEASNVLVGEVDFLERPIIAFVRLAPAVLLSGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSI 512

  Fly   392 ATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRP--- 453
            ||||:|||||:|||:|:.|:.||||:|||||.|||||||||||:||||||.::||||.||.|
Mouse   513 ATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFP 577

  Fly   454 -------PELPKEEVDEEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVA 511
                   .:.|||:......|        |.||||||||||.|||||||:::||:|||||:||:|
Mouse   578 NGSAAMSVDPPKEDDHHAGPE--------LQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLA 634

  Fly   512 SWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFE 576
            |.:|||.||:||:|||||||.|||...::|:|||....:.|:.|..|:|||||||||||||||||
Mouse   635 SILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFE 699

  Fly   577 SIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAI 641
            .|:::||......|::.|..||:|.:.:||||.|.|||:|||||||||||.||.||..||||:|:
Mouse   700 KILFKFCRDYHLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEAL 764

  Fly   642 ENVMVIGKNFPVNQ-------GIYDCVCTPPIGSNASVIDYAK--------YNW-----DSCESY 686
            |.:..:|:.:..|.       ..|.|||..|...:...::..|        .:|     ..|:::
Mouse   765 EKLFHLGEIYAFNMHNNLDELTSYTCVCAEPSNPSNETLELWKRKNITAYSVSWGNLTVSECKTF 829

  Fly   687 NGTLVGGDCGT--PPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFA 749
            :|..||..||.  |...:|....|||...||.:|:.||:||...:||:.||..||||:|.:.|..
Mouse   830 HGMFVGSACGPHGPYVPDVLFWCVVLFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVI 894

  Fly   750 MSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQIT 814
            |...||.:|:|:.||.||.:.:||..:|||:|.|..: ||||:.:||..||||.|||||||||||
Mouse   895 MVAIDYLVGIPSPKLHVPEKFEPTDPSRGWIISPLGD-NPWWTLLIAAVPALLCTILIFMDQQIT 958

  Fly   815 AVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEK 879
            |||:||||:|||||.||||||.::.:::.:||:||||||||||||||:||||||:|||||||||:
Mouse   959 AVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSIMGLPWFVAATVLSISHVNSLKVESECSAPGEQ 1023

  Fly   880 PQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMP 944
            |:|||:||||||.::||:.:|:||.:|.:|..||||||:||||||||:||||:||||||.:..||
Mouse  1024 PKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQFFDRIKLFGMP 1088

  Fly   945 AKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTR 1009
            ||:|||.::||.||:.:||:||::||.||::||:||: |..:::||:|::.::.:||.:||.||:
Mouse  1089 AKHQPDLIYLRYVPLWKVHVFTVVQLTCLVLLWVIKA-SAAAVVFPMMVLALVFVRKLMDLCFTK 1152

  Fly  1010 RELKILDDIMPEMTKRAAADDLHKLDAE--------DNHHQHPP---GSGAGANYNADKSGPTTI 1063
            |||..|||:||| :|:...||..|.:.|        |....|.|   ||              .:
Mouse  1153 RELSWLDDLMPE-SKKKKEDDKKKKEKEEAERMLQDDEDTVHLPFERGS--------------LL 1202

  Fly  1064 HIPLSGNKTGTKGPTVNIPQEAVNRTAVWQQINKDGNGISEQLIIPVTLKVRQINGN-HAPSSAT 1127
            .||:...|.......|||..| :.:||.|:.::.:..          ..||.:.|.: ..|.|.|
Mouse  1203 QIPVKTLKYSIDPSVVNISDE-MAKTAQWKALSMNTE----------NAKVTRPNTSPEKPVSVT 1256

  Fly  1128 LSPRLSPMHEADEYSEAPTN 1147
            ::....|   :.:|.:|.|:
Mouse  1257 INFEDEP---SKKYMDAETS 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	500/1050 (48%)
		Band_3_cyto	167..435	CDD:284893	157/409 (38%)
		HCO3_cotransp	476..968	CDD:279322	286/513 (56%)
Slc4a7	XP_006518061.1	Band_3_cyto	118..1159	CDD:391624	500/1050 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832148
Domainoid	1	1.000	288	1.000	Domainoid score	I1560
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2680
Inparanoid	1	1.050	1037	1.000	Inparanoid score	I268
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840