DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and Slc4a3

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001344078.1	Gene:	Slc4a3 / 20536	MGIID:	109350	Length:	1227	Species:	Mus musculus

Alignment Length:	1264	Identity:	415/1264 - (32%)
Similarity:	594/1264 - (46%)	Gaps:	301/1264 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ELPWTMNSSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVH---------------VP 58
            :|..|:..|...|...|.|....|..::.::|.|||.|| ||.:...|               .|
Mouse    37 DLGKTLAVSRFGDLISKTPAWDPEKPSRSYSERDFEFHR-HTSHHTHHPLSARLPPPHKLRRPPP 100

  Fly    59 GGRRHSQRRRKHHH-SGPGGGGGGGGGGGSIGGSGSV--GGGAGKDNVSEKQQEVE-----RPVT 115
            ...||::|:||... |.|..           .|:..:  .||||.:...|:::|.|     .||.
Mouse   101 TSARHTRRKRKKEKTSAPPS-----------EGTPPIQEEGGAGAEEEEEEEEEEEGESEAEPVE 154

  Fly   116 P----PAQRVQFILGEDVDD-------------------------------------GTHVS--- 136
            |    |.|:.:|.:|.|.||                                     .:.:|
Mouse   155 PLPPGPPQKAKFSIGSDEDDSPGLPVKAPCAKALPSVGLQSDQSPQRSGSSPSPRARASRISTEK 219

  Fly   137 ----------------------------------------------------------------- 136

Mouse   220 SRPWSPSASYDLRERLCPGSALGNPGPEQRVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLV 284

  Fly   137 ---------------------------------HPLFSEMG-MLVKEGDEIEWKETARWIKFEED 167
                                             |.:|.|:. :::....|..|:|||||||||||
Mouse   285 KKPSRIQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEED 349

  Fly   168 VEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKD 232
            |||...||.|||||:||..||.||||.:..|:.:||:|...|..:|.||.:.|:.:..:.|..:.
Mouse   350 VEEETERWGKPHVASLSFRSLLELRRTIAQGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRA 414

  Fly   233 KVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSK-KKKSNSKHSRPAQNLSSITEDMVKSP 296
            .|...||.:|.|.::.......|        ||.|||. .....:.|..|:.........|....
Mouse   415 SVLRTLLLKHSHPNDDKDSGFFP--------RNPSSSSVNSVLGNHHPTPSHGPDGAVPTMADDQ 471

  Fly   297 SNQSMARP--------------GSGTELSEQQHKGNT-HFMRKIPPGAEASNILVGEVDFLERTL 346
            ...:...|              |.|       |:|.: ..:.|||..|||:.:|||.|.|||:..
Mouse   472 GEPAPLWPHDPDAKEKPLHMPGGDG-------HRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPA 529

  Fly   347 SCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRD 411
            :.|:|||:||:|..:.|||||.||:|::|||..:.:::||:||::||||||::|||.||:|..|.
Mouse   530 AAFVRLSEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQ 594

  Fly   412 HLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEEEEARLR----- 471
            .||..:.||||...|:||.|.:....:...||...:.:|||      .|.::.:.|...|
Mouse   595 DLLGAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKR------REREQTKVEMTTRGGYAA 653

  Fly   472 ----------------EENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFAC 520
                            |::.|.|||.:||||:.|:||:.|.|.||.:|||..||||:.:|:|||.
Mouse   654 PGKELSLEMGGSEATSEDDPLQRTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAA 718

  Fly   521 LSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLK 585
            |||.|||||||.|.|...|...|.:||..|.|:.:.....|||.::|.:||:||||...::||..
Mouse   719 LSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRA 783

  Fly   586 MGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKN 650
            ...:|:|.|.|:|:|:....:.|.|.:.|.||.||:.||:|.||.||:.||||:....:..:...
Mouse   784 QDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTE 848

  Fly   651 FPVNQGIYDCVCTPP-------IGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTE------- 701
            .|: ...|     ||       :..|:|.:                        ||||
Mouse   849 HPL-LPFY-----PPDEALETGLELNSSAL------------------------PPTEGPPGPRN 883

  Fly   702 --NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQK 763
              |..|:|::|..|||||:..|::|:|:.|.....|:.|.||.:.|:|..|...|||: ...|||
Mouse   884 QPNTALLSLILMLGTFLIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQK 948

  Fly   764 LEVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKL 825
            |.||..|..|. ..|.|.|||.....|:  |..:.|..||||..|||||:.||||:||::|..:|
Mouse   949 LTVPTGLSVTSPHKRTWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRL 1013

  Fly   826 KKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRV 890
            .||.|:||||.::..|..:|.:.||||..||||.|:.|||:|.:.....|||:|||...||||||
Mouse  1014 LKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRV 1078

  Fly   891 THILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLR 955
            |.:||...:|:|:::..:|..||:.||||:||||||.||.|:|...|:|::|||||:.|:..::.
Mouse  1079 TGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIFMPAKHHPEQPYVT 1143

  Fly   956 QVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKA-LDLVFTRRELKILD--D 1017
            :|...|:||||.|||.|:.:||::|| :..|:.||.:|::.:.:|:. |..:|..|||:.||  |
Mouse  1144 KVKTWRMHLFTCIQLGCIALLWVVKS-TAASLAFPFLLLLTVPLRRCLLPRLFQDRELQALDSED 1207

  Fly  1018 IMPEMTKRAAADDLHKLDAEDNHHQ-HPP 1045
            ..|...:          |.:|.::: |.|
Mouse  1208 AEPNFDE----------DGQDEYNELHMP 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	363/934 (39%)
		Band_3_cyto	167..435	CDD:284893	106/283 (37%)
		HCO3_cotransp	476..968	CDD:279322	216/511 (42%)
Slc4a3	NP_001344078.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..256		43/230 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..312		0/25 (0%)
		ae	321..1226	CDD:273290	370/966 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..497		12/83 (14%)
		Membrane (anion exchange)	708..1227		222/560 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.670