Protein Alignment Ndae1 and Slc4a1

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_035533.1
• Gene: Slc4a1 / 20533
• MGIID: 109393
• Length: 929
• Species: Mus musculus
• Alignment Length: 985
• Identity: 340/985 - (34%)
• Similarity: 520/985 - (52%)
• Gaps: 129/985 - (13%)

  Fly   105 EKQQEVER------------PVT----PPAQRVQFILGEDVDDGTHVSHP----LFSEMG--MLV 147
            :.::|:|.            |||    |.|...:....:.|...|...||    ::.|:.  |:.
Mouse    17 DSEEELENIIGQIAYRDLTIPVTEMQDPEALPTEQTATDYVPSSTSTPHPSSGQVYVELQELMMD 81

  Fly   148 KEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVM 212
            :...|::|.|.|.||..||::.|.| .|.:||::.|:..||.||:::...|:.:|.:...:|..:
Mouse    82 QRNQELQWVEAAHWIGLEENLREDG-VWGRPHLSYLTFWSLLELQKVFSKGTFLLGLAETSLAGV 145

  Fly   213 ADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSNSK 277
            |:.:.|..:....:.|..::::..|||.:..|..:.                         .|.:
Mouse   146 ANHLLDCFIYEDQIRPQDREELLRALLLKRSHAEDL-------------------------GNLE 185

  Fly   278 HSRPA--QNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKG-----NTHFMRKIPPGAEASNIL 335
            ..:||  ......:|.::..       :|...|:|...|.:|     :|....||||.:|.:.:|
Mouse   186 GVKPAVLTRSGGASEPLLPH-------QPSLETQLYCGQAEGGSEGPSTSGTLKIPPDSETTLVL 243

  Fly   336 VGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIF 400
            ||..:|||:.:..|:||.:||.|.||. :|.|..|:.:||||.....::.::|||.||||::.:|
Mouse   244 VGRANFLEKPVLGFVRLKEAVPLEDLV-LPEPVGFLLVLLGPEAPHVDYTQLGRAAATLMTERVF 307

  Fly   401 HEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPA------AIPSQEVRKRPPELPKE 459
            ...|..|..|:.||..::.|||...||||        .:.|:      .:|.|:...|...||..
Mouse   308 RITASMAHNREELLRSLESFLDCSLVLPP--------TDAPSEKALLNLVPVQKELLRRRYLPSP 364

  Fly   460 EVDEEEEEARL----------REENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWI 514
            ...:......|          .|::.|.||||:|||||.||:|:.|:|:||..||||.|.:|:.|
Mouse   365 AKPDPNLYNTLDLNGGKGGPGDEDDPLRRTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVI 429

  Fly   515 FLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESII 579
            |:|||.|||.:||||||.|.|...|...|.|:|..|.|:.:.....|||.:||.:||:||||...
Mouse   430 FIYFAALSPAVTFGGLLGEKTRNLMGVSELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAF 494

  Fly   580 YEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENV 644
            :.||.....:|:..|.|||.|:..:.:::.|.:.|.||.||:|:|:|.|:.||:.||||:....:
Mouse   495 FSFCESNNLEYIVGRAWIGFWLILLVMLVVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKL 559

  Fly   645 MVIGKNFPVNQGIYDCVCTP-PIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSV 708
            :.|.:::|:.|.....|..| |.|                               |..|..|.|:
Mouse   560 IKIFQDYPLQQTYAPVVMKPKPQG-------------------------------PVPNTALFSL 593

  Fly   709 VLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFD-YSLGVPTQKLEVPNELK- 771
            ||.|||||::..|::|||:.:||..:|:.|.||.|.|:|..|...| :..|..||||.||:.||
Mouse   594 VLMAGTFLLAMTLRKFKNSTYFPGKLRRVIGDFGVPISILIMVLVDSFIKGTYTQKLSVPDGLKV 658

  Fly   772 PTLSTRGWLIPP--FVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLD 834
            ...|.|||:|.|  .....|.|....:|.||||..||||::.|||.:||::.|.|:.||.|:|||
Mouse   659 SNSSARGWVIHPLGLYRLFPTWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLD 723

  Fly   835 LFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTI 899
            |.::..:..:.::.|:||..|.||.|:.|.|:|.:..:.|.||...|...|:|||::.:|:.:.:
Mouse   724 LLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASGPGAAAQIQEVKEQRISGLLVSVLV 788

  Fly   900 GVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHL 964
            |:|:|:.|:|..||:.||||:||||||.||.|:|.|||||::|.|.||.||..|:::|...|:||
Mouse   789 GLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHL 853

  Fly   965 FTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILDDIMPEMTKRAAA 1028
            ||.||:.||.:||::|| :..|:..|.:|::.:.:|: .|.|:|...||:.||....::|    .
Mouse   854 FTGIQIICLAVLWVVKS-TPASLALPFVLILTVPLRRLILPLIFRELELQCLDGDDAKVT----F 913

  Fly  1029 DDLHKLDAED 1038
            |:.:.||..|
Mouse   914 DEENGLDEYD 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	322/906 (36%)
Slc4a1	NP_035533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..67		4/20 (20%)
		Globular. /evidence=ECO:0000250	69..303		72/267 (27%)
		ae	72..928	CDD:273290	329/930 (35%)
		Interaction with ANK1. /evidence=ECO:0000250	190..199		1/8 (13%)
		Dimerization arm. /evidence=ECO:0000250	317..370		16/60 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	366..389		2/22 (9%)