DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and slc4a3

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_017945570.1	Gene:	slc4a3 / 100495394	XenbaseID:	XB-GENE-996901	Length:	991	Species:	Xenopus tropicalis

Alignment Length:	1095	Identity:	399/1095 - (36%)
Similarity:	589/1095 - (53%)	Gaps:	162/1095 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKNEYIELPWTMNSSSGDDEAPKDPR--TGGEDFTQQFTENDFEGHRA-HTVYVGVHVPGG---- 60
            |..|| |.....|..|..:.|.::.|  .|.||| ::|. .|||.:.. .::...::.|.|
Frog     6 EGEEY-EGKGETNELSRKESASRNMRNSVGHEDF-EEFV-LDFEDYDLWESIKTHLNDPEGTSSC 67

  Fly    61 ---------RRHSQRRRKHHHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTP 116
                     |||.                                 |.|:.||.|:..:..|:..
Frog    68 VNLDDQSTLRRHI---------------------------------AAKNRVSRKEPTITAPIWT 99

  Fly   117 PAQRVQFILGEDVDDGTHVSHPLFSEMGMLVKEG-DEIEWKETARWIKFEEDVEEGGNRWSKPHV 180
            .|:|.:       |.|   .|.:|.|:..|:.|| .:::|:||||||||||:||:..:||.||||
Frog   100 RAKRKR-------DKG---PHEVFVELNELICEGVHKMQWRETARWIKFEENVEQETSRWGKPHV 154

  Fly   181 ATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQ 245
            |:||..||.|||:.:.||::.||:|...:..:...:.|.||.:..:....:..|:.|||.:|.|.
Frog   155 ASLSFRSLLELRKTITNGTLFLDLEQTTMPRIVQTIVDTMVVSEQIGACDRASVQRALLLKHSHP 219

  Fly   246 HEYAKKTRLPIIRSLADMRNHSSSKKKKSNSKH----SRPAQNLSSITEDMVKSPSNQSMARPGS 306
            ::..:             .:|..|....|...|    |.|.:|..|      ||....|..:..:
Frog   220 NDGRE-------------AHHPRSSTGSSTGNHLENNSPPIENSFS------KSHDADSKQKTLN 265

  Fly   307 GTELSEQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFV 371
            |.|....:|   ...|.|||..|||:.:|||.|||||:..:.|:||.:||:|..:.|||:|.||:
Frog   266 GPEGHRMKH---WKLMEKIPENAEATVVLVGCVDFLEQAATAFVRLDEAVLLESVLEVPIPVRFL 327

  Fly   372 FILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTI 436
            ::||||..:..::|||||:::|||||::|||.||.|..|..||:.::||||...||||.|.....
Frog   328 YVLLGPTQANMDYHEIGRSISTLMSDKVFHEAAYTAAGRQDLLNAINEFLDCSMVLPPCEMQSKD 392

  Fly   437 RIEPPAAIPSQEVRKR-------------PPELPKEEV--------DEEEEEARLREENGLSRTG 480
            .:...||.....:|||             ||.:..:.|        |||::|:   :.:.|.|:|
Frog   393 LLRSIAAFQKDLLRKRREREQRRSARENVPPTVQGQSVEARQLKPDDEEDDES---QSDPLERSG 454

  Fly   481 RLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESL 545
            .|||||:.||:|:...|.||.||.|:.||:|:.:|:|||.|||.|||||||.|.|...|...|.:
Frog   455 YLFGGLVRDIRRRYVKYWSDIKDGLNSQCLAAALFIYFAALSPAITFGGLLGEKTQGLMGVSELI 519

  Fly   546 VSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTA 610
            ||..|.|:.:...:.|||.|:|.:||:||||...::||.....:|:|.|.|||.|:....:|:.|
Frog   520 VSTSVLGVIFALLAAQPLLIVGFSGPLLVFEEAFFKFCQVQEIEYLTGRVWIGFWLIFFILVMVA 584

  Fly   611 IDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDY 675
            .:.|.||.||:.||:|.||.||:.|||::....:..:....|:.:      ..||:|:
Frog   585 AEGSFLVRYISPFTQEIFAFLISLIFIHETFYKLYKVFAEHPLLR------TYPPVGA------- 636

  Fly   676 AKYNWDSCESYNGTLVGGDCGTPP--TENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYI 738
                          :||......|  ..|..|:|::|..|||||:..|::|||:.|.....|:.|
Frog   637 --------------VVGRTAALGPRMQPNTALLSLILMVGTFLIAFFLRKFKNSRFLGGQARRVI 687

  Fly   739 SDFSVLIAIFAMSFFDYSL-GVPTQKLEVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFP 799
            .||.:.|:|..|.|.||:: ...||||.||:.|..|. ..|||.|.|.....|:  |....:..|
Frog   688 GDFGIPISILVMVFIDYAITDTYTQKLNVPSGLSVTSPGKRGWFIDPMGTSKPFPLWMMFASAIP 752

  Fly   800 ALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHV 864
            |||..||:||:.|||.:||:|||.:|:||.|:||||.::..|..:|::.||||..|.||.|:.|:
Frog   753 ALLVFILMFMETQITTLIVSRKERRLQKGSGFHLDLLLIGSLGGVCALFGLPWLTATTVRSVTHI 817

  Fly   865 NSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASL 929
            |:|.:.|: :||||||:...|:|||||.:||...:|:|:::..:|..||:.||||:||||||.||
Frog   818 NALTVMSK-TAPGEKPRIAEVKEQRVTAVLISALVGLSIVMGEMLRQIPLAVLFGIFLYMGVTSL 881

  Fly   930 KGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLV 994
            .|:|.|:|:|::.|..|:.|::.::.:|...|:||||.:||:|::|||::|| |..|:.||.:|:
Frog   882 TGIQLFERLLLILMHPKHHPEHPYVVKVCTWRMHLFTCVQLSCIVILWVVKS-SPASLAFPFLLI 945

  Fly   995 VMIGIRK-ALDLVFTRRELKILD--DIMPEMTKRAAADDLHKLDAEDNHHQ-HPP 1045
            :.:.:|: .|...|..||||.||  |:.|...:          |..|.::: |.|
Frog   946 LTVPLRRFVLPRFFQERELKALDSEDVEPNFDE----------DGRDEYNELHMP 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	359/908 (40%)
		Band_3_cyto	167..435	CDD:284893	103/271 (38%)
		HCO3_cotransp	476..968	CDD:279322	208/497 (42%)
slc4a3	XP_017945570.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010