Protein Alignment Ndae1 and slc4a3

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_017945570.1
• Gene: slc4a3 / 100495394
• XenbaseID: XB-GENE-996901
• Length: 991
• Species: Xenopus tropicalis
• Alignment Length: 1095
• Identity: 399/1095 - (36%)
• Similarity: 589/1095 - (53%)
• Gaps: 162/1095 - (14%)

  Fly     3 EKNEYIELPWTMNSSSGDDEAPKDPR--TGGEDFTQQFTENDFEGHRA-HTVYVGVHVPGG---- 60
            |..|| |.....|..|..:.|.::.|  .|.||| ::|. .|||.:.. .::...::.|.|
 Frog     6 EGEEY-EGKGETNELSRKESASRNMRNSVGHEDF-EEFV-LDFEDYDLWESIKTHLNDPEGTSSC 67

  Fly    61 ---------RRHSQRRRKHHHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTP 116
                     |||.                                 |.|:.||.|:..:..|:..
 Frog    68 VNLDDQSTLRRHI---------------------------------AAKNRVSRKEPTITAPIWT 99

  Fly   117 PAQRVQFILGEDVDDGTHVSHPLFSEMGMLVKEG-DEIEWKETARWIKFEEDVEEGGNRWSKPHV 180
            .|:|.:       |.|   .|.:|.|:..|:.|| .:::|:||||||||||:||:..:||.||||
 Frog   100 RAKRKR-------DKG---PHEVFVELNELICEGVHKMQWRETARWIKFEENVEQETSRWGKPHV 154

  Fly   181 ATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQ 245
            |:||..||.|||:.:.||::.||:|...:..:...:.|.||.:..:....:..|:.|||.:|.|.
 Frog   155 ASLSFRSLLELRKTITNGTLFLDLEQTTMPRIVQTIVDTMVVSEQIGACDRASVQRALLLKHSHP 219

  Fly   246 HEYAKKTRLPIIRSLADMRNHSSSKKKKSNSKH----SRPAQNLSSITEDMVKSPSNQSMARPGS 306
            ::..:             .:|..|....|...|    |.|.:|..|      ||....|..:..:
 Frog   220 NDGRE-------------AHHPRSSTGSSTGNHLENNSPPIENSFS------KSHDADSKQKTLN 265

  Fly   307 GTELSEQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFV 371
            |.|....:|   ...|.|||..|||:.:|||.|||||:..:.|:||.:||:|..:.|||:|.||:
 Frog   266 GPEGHRMKH---WKLMEKIPENAEATVVLVGCVDFLEQAATAFVRLDEAVLLESVLEVPIPVRFL 327

  Fly   372 FILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTI 436
            ::||||..:..::|||||:::|||||::|||.||.|..|..||:.::||||...||||.|.....
 Frog   328 YVLLGPTQANMDYHEIGRSISTLMSDKVFHEAAYTAAGRQDLLNAINEFLDCSMVLPPCEMQSKD 392

  Fly   437 RIEPPAAIPSQEVRKR-------------PPELPKEEV--------DEEEEEARLREENGLSRTG 480
            .:...||.....:|||             ||.:..:.|        |||::|:   :.:.|.|:|
 Frog   393 LLRSIAAFQKDLLRKRREREQRRSARENVPPTVQGQSVEARQLKPDDEEDDES---QSDPLERSG 454

  Fly   481 RLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESL 545
            .|||||:.||:|:...|.||.||.|:.||:|:.:|:|||.|||.|||||||.|.|...|...|.:
 Frog   455 YLFGGLVRDIRRRYVKYWSDIKDGLNSQCLAAALFIYFAALSPAITFGGLLGEKTQGLMGVSELI 519

  Fly   546 VSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTA 610
            ||..|.|:.:...:.|||.|:|.:||:||||...::||.....:|:|.|.|||.|:....:|:.|
 Frog   520 VSTSVLGVIFALLAAQPLLIVGFSGPLLVFEEAFFKFCQVQEIEYLTGRVWIGFWLIFFILVMVA 584

  Fly   611 IDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDY 675
            .:.|.||.||:.||:|.||.||:.|||::....:..:....|:.:      ..||:|:
 Frog   585 AEGSFLVRYISPFTQEIFAFLISLIFIHETFYKLYKVFAEHPLLR------TYPPVGA------- 636

  Fly   676 AKYNWDSCESYNGTLVGGDCGTPP--TENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYI 738
                          :||......|  ..|..|:|::|..|||||:..|::|||:.|.....|:.|
 Frog   637 --------------VVGRTAALGPRMQPNTALLSLILMVGTFLIAFFLRKFKNSRFLGGQARRVI 687

  Fly   739 SDFSVLIAIFAMSFFDYSL-GVPTQKLEVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFP 799
            .||.:.|:|..|.|.||:: ...||||.||:.|..|. ..|||.|.|.....|:  |....:..|
 Frog   688 GDFGIPISILVMVFIDYAITDTYTQKLNVPSGLSVTSPGKRGWFIDPMGTSKPFPLWMMFASAIP 752

  Fly   800 ALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHV 864
            |||..||:||:.|||.:||:|||.:|:||.|:||||.::..|..:|::.||||..|.||.|:.|:
 Frog   753 ALLVFILMFMETQITTLIVSRKERRLQKGSGFHLDLLLIGSLGGVCALFGLPWLTATTVRSVTHI 817

  Fly   865 NSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASL 929
            |:|.:.|: :||||||:...|:|||||.:||...:|:|:::..:|..||:.||||:||||||.||
 Frog   818 NALTVMSK-TAPGEKPRIAEVKEQRVTAVLISALVGLSIVMGEMLRQIPLAVLFGIFLYMGVTSL 881

  Fly   930 KGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLV 994
            .|:|.|:|:|::.|..|:.|::.::.:|...|:||||.:||:|::|||::|| |..|:.||.:|:
 Frog   882 TGIQLFERLLLILMHPKHHPEHPYVVKVCTWRMHLFTCVQLSCIVILWVVKS-SPASLAFPFLLI 945

  Fly   995 VMIGIRK-ALDLVFTRRELKILD--DIMPEMTKRAAADDLHKLDAEDNHHQ-HPP 1045
            :.:.:|: .|...|..||||.||  |:.|...:          |..|.::: |.|
 Frog   946 LTVPLRRFVLPRFFQERELKALDSEDVEPNFDE----------DGRDEYNELHMP 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	359/908 (40%)
slc4a3	XP_017945570.1	Band_3_cyto	113..990	CDD:452680	366/940 (39%)