Protein Alignment Ndae1 and slc4a5

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_012814906.1
• Gene: slc4a5 / 100494100
• XenbaseID: XB-GENE-854491
• Length: 1126
• Species: Xenopus tropicalis
• Alignment Length: 1163
• Identity: 507/1163 - (43%)
• Similarity: 702/1163 - (60%)
• Gaps: 165/1163 - (14%)

  Fly    20 DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGGRRHSQRRR-------------KHH 71
            |||:.:          :::.|.:    ..|::|:||..|...|..:|||             ||:
 Frog     3 DDESSR----------RRYDEEE----EYHSIYIGVPAPRSYRRKRRRRRSLSSRDRSSENEKHY 53

  Fly    72 ----HSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDG 132
                ||....|                    |:.|...:..::.|.::|.|:|:::|||||.|
 Frog    54 VRDEHSDTDEG--------------------GRLNFDNESFDISRTMSPAAERLRYILGEDDD-- 96

  Fly   133 THVSHP-LFSEMGMLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLV 196
              :.:| ||:||..|.:||||:|||||||||||||.|||||.|||||||:||:||||||||..|.
 Frog    97 --IPNPTLFTEMDTLQQEGDELEWKETARWIKFEEKVEEGGERWSKPHVSTLTLHSLFELRTCLQ 159

  Fly   197 NGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLA 261
            .||||||::..:|..:.|.|....:..|.|.|.::||:...|||:||||      |:.||.|||.
 Frog   160 TGSVMLDLDGYSLSQIVDDVIQRQIEDGNLNPELRDKISFVLLRKHRHQ------TKKPIHRSLV 218

  Fly   262 DMRNHSSSKKKKSNSKHSRPAQNLSS---ITEDM-VKSPSNQSMARPG---SGTELSE----QQH 315
            |:....||    |.|:...|...:.:   .|||: ::..:|....|..   |..::||    .|.
 Frog   219 DIGKSVSS----STSRIQTPGTPVGTHFRSTEDLRMRQNANYGRLRHAHSRSMNDISETPSSDQL 279

  Fly   316 KGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGS 380
            |..  |::|||..|||||:||||||||::....|:||:|:::||.:|||||||||:||||||.|.
 Frog   280 KNK--FIKKIPRDAEASNVLVGEVDFLDKPFVAFVRLAQSIMLGGVTEVPVPTRFLFILLGPMGK 342

  Fly   381 QSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIP 445
            ..::.|||||:||||.|:||.:|||:|:.|:.|::|:|||||.|.||||||||||||||||..||
 Frog   343 AKSYIEIGRAIATLMVDDIFSDVAYKAKDREDLIAGIDEFLDEVIVLPPGEWDPTIRIEPPKKIP 407

  Fly   446 SQEVRK--------------------------RPPELP-KEEVDEEEEEARLREENGLSRTGRLF 483
            |.:.||                          ...|:| ..|:.||           ::.|||..
 Frog   408 SADQRKSMFSVNEAGQMNGSAGGGAGSGGAGSEDGEMPAAHEIGEE-----------IAYTGRFC 461

  Fly   484 GGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSG 548
            |||..|||||.||..||:.:|..:|.:::.:|:|..|::..|||||||.:||..:...|||.:..
 Frog   462 GGLYLDIKRKLPWIPSDFYEAFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGT 526

  Fly   549 FVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDA 613
            .:.|..:..|:||||.||.||||:|:||.::::|......|||.||.|||:..|..|::|.|.||
 Frog   527 AMAGSVFCLFAGQPLIILSSTGPILIFEKLLFDFSKGNNIDYMEFRLWIGLHSALQCLILVATDA 591

  Fly   614 SALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQG-------IYDCVCTPP------ 665
            |.::.||||||||.|:|||:|||||.||:.::...|.:|:|..       :|.|.|..|
 Frog   592 SFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINSDFKPDYVTLYRCECVAPDPVNTT 656

  Fly   666 ------------------IGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCA 712
                              .|.||:.:|:.:.:...|..|.|:|||..|...|  ::.|||.:|..
 Frog   657 LFNASAPFAPNNSNMSLYNGINATALDWTQLSMKECLKYGGSLVGNSCKYVP--DLALMSFILFF 719

  Fly   713 GTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTR 777
            ||:.::..||:||.:.:||:.:|..::||:::..|......|....:.|.||.||:|:|||...|
 Frog   720 GTYSMTLSLKKFKFSRYFPTKLRTLVADFAIVFTILVFCGVDAFFELETPKLHVPSEIKPTRPDR 784

  Fly   778 GWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILI 842
            ||.:.|| .|||||..:.:..||||.|||||||:|||||||||||||||||||||||||.:.:|:
 Frog   785 GWFVFPF-GKNPWWIYLASALPALLVTILIFMDEQITAVIVNRKENKLKKGCGYHLDLFWVGVLM 848

  Fly   843 AICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTP 907
            |:||.|||||:|||||:||.|::|||:|:|.|||||:||||||||||||.|::|:..|:||.|.|
 Frog   849 AVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIVVFILTGISVFLAP 913

  Fly   908 LLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLAC 972
            :|..||||||:|||||||||||.|:||:||..:..||||:||||.:||.||:::|||||::|:.|
 Frog   914 VLKYIPMPVLYGVFLYMGVASLSGIQFWDRCKLFMMPAKHQPDYAYLRHVPLRKVHLFTLVQIIC 978

  Fly   973 LIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAE 1037
            |.:||::|| :..:|:||:|::.::.:||.||.||::.:|..||||:||..|:...|...|...:
 Frog   979 LAVLWILKS-TVAAIIFPVMILGLMMVRKMLDWVFSQHDLAWLDDILPEKEKKKQEDKCKKKKGK 1042

  Fly  1038 DNHHQHPPGSGAGANYNADKSGPT--------TIHIPLSGNKTGTKGPTVNIPQEAVN 1087
            |:........|.....:.|.| |:        |:|:.:|    ....|.:..|:.|:|
 Frog  1043 DDSDSDEDKGGRSGGLHGDTS-PSGSDVDRSITLHLKIS----CPPSPAIGFPKNAIN 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	454/944 (48%)
slc4a5	XP_012814906.1	Band_3_cyto	103..1021	CDD:452680	454/944 (48%)