DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and slc4a4

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_004919190.2	Gene:	slc4a4 / 100490445	XenbaseID:	XB-GENE-479125	Length:	1128	Species:	Xenopus tropicalis

Alignment Length:	1163	Identity:	518/1163 - (44%)
Similarity:	708/1163 - (60%)	Gaps:	155/1163 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DDEAPKDPRTGGEDFTQQF-TENDFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGGGGGG 83
            :|||..|   .|..|.:.. .|.:.|||  ||||:|||||...|   |||:|.|
Frog     2 EDEAVLD---RGASFLKHVCDEEEVEGH--HTVYIGVHVPKSYR---RRRRHRH----------- 47

  Fly    84 GGGSIGGSGSVGGGAGK-----------------DNVSEKQQEVERP-VTPPAQRVQFILGEDVD 130
                     ..|....|                 :|..|....:.:| ::|.|:|::|||||  |
Frog    48 ---------RTGHKEKKEKEKSSENYSDLDKSDTENADETSSSILKPLISPAAERIRFILGE--D 101

  Fly   131 DGTHVSHPLFSEMGMLVK-EGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRL 194
            |.:.....||:|:..|:. :|.|:||||||||:||||.||:||.|||||||||||||||||||..
Frog   102 DDSPAPPQLFTELDELLSVDGQEMEWKETARWLKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 166

  Fly   195 LVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRS 259
            :..|:::||:||.:|..:.:.:.|:.:..|.|...:||||...|||:||||   .||:.|   ||
Frog   167 IEKGTILLDLEANSLPQVVEKILDNQIETGLLKAELKDKVTYTLLRKHRHQ---TKKSNL---RS 225

  Fly   260 LADMRNHSSSKKK----------------------KSNSKHSRP--AQNLSSITEDMVKSPSNQS 300
            |||:....||..:                      :|..:.|.|  |..:|.....:.:|||...
Frog   226 LADIGKTVSSASRMFTSPDNGVREEGLVKNSFLSARSPLETSVPCLATRMSDDDLRVRRSPSMGL 290

  Fly   301 MARP---------GSGTELSEQQHKG--NTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQ 354
            ::.|         .|..::|::..|.  ...||:|||..|||||:|||||||||.....|:||.|
Frog   291 LSSPTMSPRNLTSSSLNDISDKPDKDQLKNKFMKKIPRDAEASNVLVGEVDFLETPFIAFVRLQQ 355

  Fly   355 AVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDE 419
            ||:.|.||||||||||:||||||.|...::|||||::|||||||:||::||:|:.|..|::|:||
Frog   356 AVMFGALTEVPVPTRFLFILLGPKGKAKSYHEIGRSIATLMSDEVFHDIAYKAKDRQDLIAGIDE 420

  Fly   420 FLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKR---PPELPKEEVDEEEEEARLREENG----LS 477
            |||.|.|||||||||.||||||.:|||.:.||.   ..|..:...|...:|......:|    |.
Frog   421 FLDEVIVLPPGEWDPAIRIEPPKSIPSSDKRKNMYAGGENVQMNGDTLHDEGHGGGGHGDCPELK 485

  Fly   478 RTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAM 542
            ||||..|||:.|||||||::.||:.||||:|.:::.:|:|...::..|||||||.:||......:
Frog   486 RTGRFCGGLVEDIKRKAPYFASDFYDALSIQSLSAMLFIYLGTVTNAITFGGLLGDATENMQGVL 550

  Fly   543 ESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIV 607
            ||.:...:.|..:...:||||.||.|||||||||.:::.|....|:||:.||.|||:|.|.:|:|
Frog   551 ESFLGTAISGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRDNGFDYLEFRLWIGLWSAFLCLV 615

  Fly   608 LTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQ-------GIYDCVCTPP 665
            |.|.|||:||.|.||||||.||.||:|||||.|.:.::.....:|:|.       .::.|.|.||
Frog   616 LVATDASSLVKYFTRFTEEGFACLISFIFIYDAFKKMIKFADYYPINTHFKVGDVTLFSCTCLPP 680

  Fly   666 IGSNASV--------IDYAK------------YNWDS-----CESYNGTLVGGDCGTPPTENVFL 705
            ..:|.|:        :|:..            .||.:     |..|.|.|||.:|...|  ::.|
Frog   681 DPANISLFNGTTESPLDFFSTTIDMDMDHNNTINWSTLTKKECLKYGGNLVGNNCKYIP--DITL 743

  Fly   706 MSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNEL 770
            ||.:|..||:..|..||:||.:.:||:..|:.||||:::::|......|..:||.|.||.||:|.
Frog   744 MSFILFFGTYACSMALKKFKTSRYFPTTARKLISDFAIILSILIFCGIDALVGVDTPKLLVPSEF 808

  Fly   771 KPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDL 835
            |||...|||.:||| ..||||..:.|..||||.|||||||||||||||||||:|||||.||||||
Frog   809 KPTSPHRGWFVPPF-GGNPWWVYLAASLPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDL 872

  Fly   836 FILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIG 900
            |.:::|:.:||.|.|||:|||||:||.|::|||:|:|.|||||:|:||||||||||.:::|:..|
Frog   873 FWVAVLMIVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTG 937

  Fly   901 VSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLF 965
            |||.:.|:|..||||||:|||||||||||.|:||.||:.::.||||:|||:::||.||::|||||
Frog   938 VSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPAKHQPDFIYLRHVPLRRVHLF 1002

  Fly   966 TMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADD 1030
            |.||:.||.:||::|| :..:|:||:|::.::.:|||:|.:|::.:|..|||::||..|:...|:
Frog  1003 TFIQILCLALLWILKS-TVAAIIFPVMILALVAVRKAMDYLFSQHDLGFLDDVIPEKDKKKKEDE 1066

  Fly  1031 LHKLDAEDNHHQHPPGSGAGANYNADKSGPTTIHIPLSGNKTGTKGPTVNIPQEAVNR 1088
            ..|        :...||....|.::|        .|.|     .|.|::.||.:.:.:
Frog  1067 KKK--------KKKKGSVDSDNEDSD--------TPYS-----EKVPSIKIPMDIMEK 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	459/950 (48%)
		Band_3_cyto	167..435	CDD:284893	142/302 (47%)
		HCO3_cotransp	476..968	CDD:279322	266/523 (51%)
slc4a4	XP_004919190.2	Band_3_cyto	111..1052	CDD:421404	459/950 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7549
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm48003
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010