Protein Alignment Ndae1 and slc4a8

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_002933752.2
• Gene: slc4a8 / 100487245
• XenbaseID: XB-GENE-6050275
• Length: 1096
• Species: Xenopus tropicalis
• Alignment Length: 1124
• Identity: 559/1124 - (49%)
• Similarity: 742/1124 - (66%)
• Gaps: 106/1124 - (9%)

  Fly    20 DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGGRR-------HSQRRRKHHHSGPGG 77
            |:||..|...........:.:.:.||||  |:||||.:|.||:       |.|:.||....
 Frog    18 DEEAIVDQGGTSSVLNIHYEKEELEGHR--TLYVGVRMPLGRQSHRHHRTHGQKHRKRDRM---- 76

  Fly    78 GGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSE 142
                                  |..:.|:..:.......|:||||||||.: ||..||.|.||:|
 Frog    77 ----------------------KGVIQEEGHDESSAHDTPSQRVQFILGTE-DDEEHVPHELFTE 118

  Fly   143 MG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEA 206
            :. :.||||::.||||||||:|||||||:||.|||||:|||||||||||||..::||:|.|||.|
 Frog   119 LDEICVKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCIINGTVQLDMRA 183

  Fly   207 QNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKK 271
            ..:|.:||::.||..||..|...::.|||:|||::|.||.|..:...:|::||.|::       .
 Frog   184 NTIEEVADMILDHQDSANELGDNIRVKVKEALLKKHHHQIEKKRNNLIPMVRSFAEV-------G 241

  Fly   272 KKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPG-----SGTELSEQQHKGNTHFMRKIPPGAEA 331
            ||.:..|.....:||...:   .:||...:...|     |..:||    |.:.|||:|||.||||
 Frog   242 KKQSEPHLLDKNSLSVSPQ---PTPSTLDVKNGGSHENSSSVDLS----KVDLHFMKKIPTGAEA 299

  Fly   332 SNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMS 396
            ||:||||:|||||.:..|:|||.||:|..|||||:||||:||||||.|....:|||||:|||:|:
 Frog   300 SNVLVGELDFLERPIVAFVRLSPAVLLTGLTEVPIPTRFLFILLGPVGKAQQYHEIGRSMATIMT 364

  Fly   397 DEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPKEEV 461
            |||||:|||:|:.|..||:|:|||||.|||||||||||:||||||..:||||.||. |.:|...|
 Frog   365 DEIFHDVAYKAKDRGDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKM-PGVPNGNV 428

  Fly   462 DEEEEEARLREENG--LSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPI 524
            ...|.|.. .|.:|  |.|||.:||||:.|||||||:|:|||:||||:|||||::|||.||:||:
 Frog   429 CHVEPEPE-PEHSGPELQRTGMIFGGLVADIKRKAPFYLSDYRDALSLQCVASFLFLYCACMSPV 492

  Fly   525 ITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWD 589
            |||||||.|||...::|:|||....:.|:.|..|:|||||||||||||||||.|:::||.:.|..
 Frog   493 ITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKEYGLS 557

  Fly   590 YMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVN 654
            |::.|..||:|.|.:||.|.|.|||:|||||||||||.||:||..||||:|||.::.:|:.:|||
 Frog   558 YLSLRACIGLWTAFLCIFLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLGETYPVN 622

  Fly   655 Q-------GIYDCVCTPPIG-----------SNASV--IDYAKYNWDSCESYNGTLVGGDCG--T 697
            .       .:|.|.|..|..           :|.::  .::|.:....|...:|..||..||  .
 Frog   623 MHSQLDKLTLYYCKCAAPASPTNDTLLYWRENNITITEAEWANFTVSECNKMHGEFVGPACGHHG 687

  Fly   698 PPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQ 762
            |.|.:|...|.:|...||.:|:|||.||.:.:||:.||..:|||:|.:.|..|...||.:|||:.
 Frog   688 PYTPDVLFWSCILFFTTFALSSVLKTFKTSRYFPTKVRSMVSDFAVFLTILTMVVLDYVIGVPSP 752

  Fly   763 KLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKK 827
            ||:||||.|||...||||:.| :..||||:....:.||||.||||||||||||||:||||:||||
 Frog   753 KLQVPNEFKPTRDDRGWLVNP-IGPNPWWTVFPTIIPALLCTILIFMDQQITAVIINRKEHKLKK 816

  Fly   828 GCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTH 892
            ||||||||.::.:::.|||:||||||||||||||.||||||||||||||||:|:|||:||||||.
 Frog   817 GCGYHLDLLVVGLMLGICSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTG 881

  Fly   893 ILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQV 957
            ::||:.:|.||.:|.:|..||||||:||||||||:||:|:|||||:|:..||||:|||:.:||.|
 Frog   882 LMIFVLMGCSVFMTTVLKFIPMPVLYGVFLYMGVSSLRGIQFFDRLLLFAMPAKHQPDFSYLRHV 946

  Fly   958 PIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEM 1022
            |:::|||||:|||.||::||:||: |..:|:||:|::.::.:||.:|..|:.|||..|||:|||.
 Frog   947 PLRKVHLFTIIQLTCLVLLWVIKA-SPAAIVFPMMVLALVFVRKVMDFCFSDRELSWLDDLMPES 1010

  Fly  1023 TKRAAADDLHKLDAEDNHHQHPPGSGAGANYNADKSGPTTIHIPLS--------GNKTGTKG-PT 1078
            .|:       |||...|..:....|....:...||.    :.:||.        |....::| |:
 Frog  1011 KKK-------KLDDAKNKAKELEESEKMLHEGEDKG----VQLPLETRKLLSSPGKNNNSRGDPS 1064

  Fly  1079 -VNIPQEAVNRTAVWQQIN 1096
             :||..| :.:|.||:.::
 Frog  1065 EINISDE-MPKTTVWKALS 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	497/905 (55%)
		Band_3_cyto	167..435	CDD:284893	145/272 (53%)
		HCO3_cotransp	476..968	CDD:279322	293/513 (57%)
slc4a8	XP_002933752.2	Band_3_cyto	116..1044	CDD:391624	511/956 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	597	1.000	Domainoid score	I202
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1038	1.000	Inparanoid score	I269
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm48003
Panther	1	1.100	-	-	LDO	PTHR11453
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.190