Protein Alignment Ndae1 and slc4a7

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_031759771.1
• Gene: slc4a7 / 100380158
• XenbaseID: XB-GENE-963950
• Length: 1260
• Species: Xenopus tropicalis
• Alignment Length: 1292
• Identity: 569/1292 - (44%)
• Similarity: 762/1292 - (58%)
• Gaps: 252/1292 - (19%)

  Fly    20 DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVP----GGRRHSQRRRKHHHSGPGGGGG 80
            |:||..|...........|.:.:.|.|||  ||:|||||    ..|||..|..:||.
 Frog    19 DEEAIVDLGKTSSTVNTNFEKEELESHRA--VYIGVHVPFARQSRRRHRHRGHRHHR-------- 73

  Fly    81 GGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERP-VTPPAQRVQFILGEDVDDGTHVSHPLFSEMG 144
                             ..::..::|:...|.| ...|:||||||||.:.||..|:.|.||:||.
 Frog    74 -----------------RRREKENDKEDGRESPNYDTPSQRVQFILGTEDDDEEHIPHDLFTEMD 121

  Fly   145 ML-VKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQN 208
            .| .::|:|.||||||||:|||||||:||:|||||:|||||||||||||..::||::||||.|..
 Frog   122 ELCFRDGEECEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTIMLDMRANT 186

  Fly   209 LEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKK 273
            :|.|:|::.|:|.::|.:...:::.|::|||:||.||:|.....|:|::||.||:     .||..
 Frog   187 IEEMSDMLLDNMTASGQMDESMREPVREALLKRHHHQNEKKLSNRIPLVRSFADI-----GKKHS 246

  Fly   274 SNSKHSRPAQNLSSITEDM------------------------------VKSPSNQSMARP---- 304
            ....|.|..:.||:....:                              |.:|.|...:.|
 Frog   247 ETHLHERNGEGLSASRNSLRAESRLSLLLNYLLPPSRAGTPAGSRRSTPVPTPQNTPPSSPTLNR 311

  Fly   305 ----------------------------------------------------GSGTELSEQQHKG 317
                                                                .||...|.|...|
 Frog   312 LPSTGSQEIEHCVPKPQPPTIDVIPTVIIHPPEEDVEMQESLDMKKQDDGDIDSGLLSSPQSVAG 376

  Fly   318 N-------------------------------------------------THFMRKIPPGAEASN 333
            |                                                 .:||||||.||||||
 Frog   377 NMDTNKTAEMKRNATGGSLENSTVDFSKDPASWHCSCGTIIMGRKRSAVDMNFMRKIPAGAEASN 441

  Fly   334 ILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDE 398
            :||||||||:|.:..|:||..||:|..|||||:||||:||||||.|....:|||||::||||:||
 Frog   442 VLVGEVDFLDRPIIAFVRLCPAVLLSGLTEVPIPTRFLFILLGPTGKGGQYHEIGRSIATLMTDE 506

  Fly   399 IFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPP----ELPKE 459
            |||:|||:|:.|:.||:|:|||||.|||||||||||:||||||.::||||.||.|.    ..|..
 Frog   507 IFHDVAYKAKDRNDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPTIPNGSTPVG 571

  Fly   460 EVDEEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPI 524
            |..:||:.....|   |.||||:||||:.|||||||:::||:||||::||:||.:|||.||:||:
 Frog   572 ETFKEEQHHTGPE---LQRTGRVFGGLMLDIKRKAPFFLSDFKDALNLQCLASVLFLYCACMSPV 633

  Fly   525 ITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWD 589
            |||||||.|||...::|:|||....:.|:.|..|:|||||||||||||||||.|:::||...|..
 Frog   634 ITFGGLLGEATQNRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYGLS 698

  Fly   590 YMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVN 654
            |::.|..||:|.|.:|::|.|.|||:|||||||||||.||.||..||||:|:|.:..:|:.:..|
 Frog   699 YLSLRTSIGLWTAFLCLLLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFHLGEKYAFN 763

  Fly   655 Q-------GIYDCVCTPPIG-SNASVIDYAKYN-------WDS-----CESYNGTLVGGDCG--T 697
            .       ..|.|||:.|:. :|.::..::|.|       ||:     |.|.|||.:|..||  .
 Frog   764 MHNDLDLLTKYSCVCSEPLDPNNETLALWSKANITASEVPWDNLTVADCVSLNGTFIGSACGHHG 828

  Fly   698 PPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQ 762
            |...:||..||:|...||.:|:.||:||...:||:.||..||||:|.:.|..|...|:.:|:|:.
 Frog   829 PYIPDVFFWSVILFFTTFFLSSFLKQFKTKNYFPTKVRSTISDFAVFLTIVIMVLVDFLVGIPSP 893

  Fly   763 KLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKK 827
            ||.||.:.:|||..|||:|.|..| ||||:.:.|..||||.||||||||||||||:||||:||||
 Frog   894 KLHVPEKFEPTLKDRGWIIDPLGE-NPWWTLLAAAIPALLCTILIFMDQQITAVIINRKEHKLKK 957

  Fly   828 GCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTH 892
            |.|||||||:::|::.:||:||||||||||||||:||||||:|||||||||:|:|||:||||||.
 Frog   958 GGGYHLDLFMVAIMLGVCSIMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTG 1022

  Fly   893 ILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQV 957
            :|||:.:|:||.:|.:|..||||||:|||||||.:||||:|.||||.:..||||:|||.::||.|
 Frog  1023 LLIFVLMGLSVFMTSVLKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFGMPAKHQPDLIYLRYV 1087

  Fly   958 PIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEM 1022
            |:.:||:||:|||.||::||:||: |..:::||:|::.::.|||.||.:||:|||..|||:|||
 Frog  1088 PLWKVHVFTVIQLTCLVLLWVIKA-SSAAVVFPMMVLALVFIRKLLDFIFTKRELSWLDDLMPE- 1150

  Fly  1023 TKRAAADDLHK---------LDAEDNHHQHPPGSGAGANYNADKSGPTTIHIPLSGNKTGTKGPT 1078
            :|:...||..|         |.||::..|            .|..|...:.||:...|.......
 Frog  1151 SKKKKEDDKKKKAKEEAERMLQAEESDVQ------------IDYEGRNLLQIPVKNLKYSLDPSV 1203

  Fly  1079 VNIPQEAVNRTAVWQQINKDGNGISEQLIIPVTLKVRQINGNHAPSSATLS-PRLSP 1134
            |||..| :.:||.|:.::.:                        |.||.:: |.|||
 Frog  1204 VNISDE-MAKTAQWKALSMN------------------------PESAKVTRPNLSP 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	497/1037 (48%)
		Band_3_cyto	167..435	CDD:284893	147/402 (37%)
		HCO3_cotransp	476..968	CDD:279322	290/513 (57%)
slc4a7	XP_031759771.1	Band_3_cyto	117..1145	CDD:421404	497/1037 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	597	1.000	Domainoid score	I202
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2680
Inparanoid	1	1.050	1038	1.000	Inparanoid score	I269
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm48003
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080