Protein Alignment Ndae1 and slc4a5b

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_073771318.1
• Gene: slc4a5b / 100006379
• ZFINID: ZDB-GENE-091112-19
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 501/1159 - (43%)
• Similarity: 691/1159 - (59%)
• Gaps: 168/1159 - (14%)

  Fly    45 GHRA-------HTVYVGVHVP-----------GGRRHSQRRRKHH----HSGPGGGGGGGGGGGS 87
            |||:       .:||:||.||           ...|||..|.|||    |:.|
Zfish    12 GHRSKHNEDEEESVYIGVPVPRSYRRKRRHRKHASRHSHDRDKHHSRHEHADP------------ 64

  Fly    88 IGGSGSVGGGAGKDNV--SEKQQE-----VERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMGM 145
                        ::|.  .|.:||     |...|:|.|:|::.||.|| |:.|..   ||:||..
Zfish    65 ------------EENCDPEEAEQENELSDVNSTVSPAAERLRHILRED-DEPTPT---LFTEMDT 113

  Fly   146 LVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLE 210
            |..||.|:||||:|||:||||.|||||.|||||||:|||||||||||..|..|.::||::..:|.
Zfish   114 LQHEGGEMEWKESARWVKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGCILLDLDGYSLP 178

  Fly   211 VMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSN 275
            .:.|.:.:..|..|.:.|.:::||...|||:||||      |:.||.|||||:...|.|.:..|.
Zfish   179 QIVDDMIEKQVQEGLIAPEIREKVSFVLLRKHRHQ------TKKPIHRSLADIGKPSPSNRSPSP 237

  Fly   276 SKHSRPAQNLSSITEDMVKSPS------NQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEASNI 334
            |..:|........|||:....|      :.|..|..:...::....:....||:|||..|||||:
Zfish   238 SPSARSGSGFHRSTEDLRARQSAGLGKLHPSQCRSMNDISVTPSSDQLKNKFMKKIPRDAEASNV 302

  Fly   335 LVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEI 399
            |:||||||::....|:||:||..||.||||||||||:|:||||.|...:::||||||||||.|::
Zfish   303 LIGEVDFLDKPFVAFVRLAQAATLGGLTEVPVPTRFLFVLLGPSGKTKSYNEIGRAMATLMVDDL 367

  Fly   400 FHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPK------ 458
            |.:|||:||.|:.|::|:|||||.|.|||||||||.||||||..:||.|:||....|.:
Zfish   368 FSDVAYKARDREDLIAGIDEFLDEVIVLPPGEWDPKIRIEPPKKLPSAEMRKSVFSLNELGQPNG 432

  Fly   459 ----EEVDEEEEEARLREENG--LSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLY 517
                .....|:||.....|.|  |..|||..|||..||||||||:.||:.:...:|.|::.:|:|
Zfish   433 NAGGGSASAEDEEMPAPHELGEELKFTGRFCGGLWLDIKRKAPWFFSDFYEGFHIQSVSAVLFIY 497

  Fly   518 FACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEF 582
            ..|::..|||||||.:||..:...|||.:...:.|..:..|.||||.||.||||:|:||.::|||
Zfish   498 LGCITNAITFGGLLGDATDNYQGVMESFLGTALAGAVFCMFGGQPLIILSSTGPILIFEKLLYEF 562

  Fly   583 CLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVI 647
            .:....|||..|.|||:.....|::|.|.|||.::.|:||||||.|::||:||||..|::.:|..
Zfish   563 SINNNIDYMEIRLWIGLHSCLQCLILVATDASYIIKYMTRFTEEGFSSLISFIFISDALKKMMST 627

  Fly   648 GKNFPVNQGI-------YDCVC-----TPPIGSNA-----SVIDYAKYNWDS----------CES 685
            ...:|::...       |.|.|     ..|:.|.:     ::.||:.:|:.:          |..
Zfish   628 FSYYPISPDFKPDLIISYRCDCQLPDQVSPLNSTSPLALENMSDYSMFNFSALDWTQISKKECLR 692

  Fly   686 YNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAM 750
            ..|:|||..|...|  ::.::|.:|..||:.::..||:||::.:||:..|..|:||:::|:|...
Zfish   693 LGGSLVGKSCKYVP--DLAMLSFILFFGTYSMTISLKKFKSSRYFPTKCRALIADFAIIISILVF 755

  Fly   751 SFFDY-------SLGVPTQ-------------------------------KLEVPNELKPTLSTR 777
            ...||       .|.||||                               ||.||.|.|||...|
Zfish   756 CAVDYGMALDTPKLHVPTQIKLRKLISDFAIFTSIMTFVGLDMFMGLKTPKLIVPTEFKPTRPDR 820

  Fly   778 GWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILI 842
            ||::.| :.:||||..:.:..||||.|||||||||||||||||||||||||||||||||.:.:|:
Zfish   821 GWIVMP-MGRNPWWMCLASFVPALLVTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFWVGVLM 884

  Fly   843 AICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTP 907
            |:||.|||||:|||||:||.|::|||:|||.|||||:||||||||||:|..|:|:..||||.:.|
Zfish   885 AVCSFMGLPWYVAATVISIAHIDSLKMESESSAPGEQPQFLGVREQRLTGTLVFVLTGVSVFMAP 949

  Fly   908 LLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLAC 972
            :|..||||||:|||||||||||.|:||::||.:..||||:|||::|||.||::||||||::|:.|
Zfish   950 ILQFIPMPVLYGVFLYMGVASLHGIQFWERIKLYLMPAKHQPDFVFLRHVPLRRVHLFTLLQITC 1014

  Fly   973 LIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAE 1037
            |.:||::|| :..:|:||:|::.::.:||||||:|::.:|..||||:|:..|:...|:..|..::
Zfish  1015 LAVLWILKS-TVAAIVFPVMILGLMVVRKALDLIFSQHDLAWLDDILPDKDKKKKEDEKKKKKSK 1078

  Fly  1038 DNHHQHPPGSGAGANYNADK------SGPTTIHIPLS-GNKTGTKGPTVNIPQE 1084
            .:.|.           |:|:      ...:::.|||. .|.:....|..:.|.|
Zfish  1079 TDEHN-----------NSDEECVCAVDSSSSLKIPLELLNPSSNPPPASHTPSE 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	449/958 (47%)
slc4a5b	XP_073771318.1	None