DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and MEF1

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_013170.1	Gene:	MEF1 / 850758	SGDID:	S000004059	Length:	761	Species:	Saccharomyces cerevisiae

Alignment Length:	698	Identity:	380/698 - (54%)
Similarity:	508/698 - (72%)	Gaps:	13/698 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSAATYT 105
            ::|||||||||||||||.|||:|:||.||..:|||||:|||||.||||:|||::||||||||||.
Yeast    69 KLRNIGISAHIDSGKTTFTERVLYYTKRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATYC 133

  Fly   106 LW----KDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCL 166
            .|    |:.:.|:||||||:|||:|||||||||||||||:|||.||||||:||:|||:|||||.:
Yeast   134 SWDKEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRV 198

  Fly   167 AFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIYFEGEHGMDIRL 231
            .||||:||:||:|:|.:.|:.||:...||.:|:|||.||:..|:|||:...|||.:|::|..|..
Yeast   199 TFINKMDRMGSDPFRAIEQLNSKLKIPAAAVQIPIGSESSLSGVVDLINRVAIYNKGDNGEIIEK 263

  Fly   232 DEIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTA 296
            ..:|::::....|:||.|||.|::.|:.:.|:|||||..|...||.|:||:.|.|:|||||:|:|
Yeast   264 GPVPENLKPLMEEKRQLLIETLADVDDEMAEMFLEEKEPTTQQIKDAIRRSTIARSFTPVLMGSA 328

  Fly   297 LKNKGVQPLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFKLEAGRFGQ 361
            |.|.|:||:|||::||||||.||.|...  ....:..||.|.||  .:.||||||||||.|::||
Yeast   329 LANTGIQPVLDAIVDYLPNPSEVLNTAL--DVSNNEAKVNLVPA--VQQPFVGLAFKLEEGKYGQ 389

  Fly   362 LTYLRCYQGVLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVNEVYAGDIFALFGVDCASGDTFT 426
            |||:|.|||.||||:.|.|.:|.|||::|||||:||::||||:||.:|:|.|.||:||||||||
Yeast   390 LTYVRVYQGRLRKGNYITNVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFGIDCASGDTF- 453

  Fly   427 TNPKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMG 491
            |:.....||.|::||:.|||::|.| |:||..|||||:.||.||||||...||.:.|||::||||
Yeast   454 TDGSVQYSMSSMYVPDAVVSLSITP-NSKDASNFSKALNRFQKEDPTFRVKFDPESKETIISGMG 517

  Fly   492 ELHLEIYAQRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGSGQYARIIGVMEPLPP- 555
            |||||||.:||.|||......|||:|::||::..|.:|||.|||||||:|||.|:||.:.|:..
Yeast   518 ELHLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLSPVDDI 582

  Fly   556 NQNTLLEFVDETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRFRLQDGGHHIVDSSELAF 620
            .:..:.|  ...||..:|.:::....||:.|:.|||.|.||::..::..:.||..|.|||:||:|
Yeast   583 TKGNIFE--TAIVGGRIPDKYLAACGKGFEEVCEKGPLIGHRVLDVKMLINDGAIHAVDSNELSF 645

  Fly   621 MLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTEGTEGWFTVYAEV 685
            ..|...|.::.|......|:||||.|.||:|.||||.|:|.|:|...:|..||.....||:.||.
Yeast   646 KTATMSAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNKLQAVIQDTENGHDEFTLKAEC 710

  Fly   686 PLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPDVQDQIVRQYQESQ 733
            .|:.|||:|..||:||||||||::|:|.|:|..|.||.:::.::|:.|
Yeast   711 ALSTMFGFATSLRASTQGKGEFSLEFSHYAPTAPHVQKELISEFQKKQ 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	168/275 (61%)
		PRK12740	48..727	CDD:237186	373/683 (55%)
		mtEFG1_II_like	347..427	CDD:293908	55/79 (70%)
		EFG_III	441..516	CDD:293919	45/74 (61%)
		EFG_mtEFG1_IV	519..636	CDD:238715	45/117 (38%)
		mtEFG1_C	641..718	CDD:239764	42/76 (55%)
MEF1	NP_013170.1	FusA	68..760	CDD:223556	380/698 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344292
Domainoid	1	1.000	344	1.000	Domainoid score	I148
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6449
Inparanoid	1	1.050	741	1.000	Inparanoid score	I75
Isobase	1	0.950	-	0	Normalized mean entropy	S370
OMA	1	1.010	-	-		QHG62898
OrthoFinder	1	1.000	-	-		FOG0003241
OrthoInspector	1	1.000	-	-		oto99235
orthoMCL	1	0.900	-	-		OOG6_100770
Panther	1	1.100	-	-	LDO	PTHR43636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R368
SonicParanoid	1	1.000	-	-		X2192
TreeFam	1	0.960	-	-
	16	15.740