Protein Alignment mEFG1 and EFL1

DIOPT Version :10

• Sequence 1: NP_609105.1
• Gene: mEFG1 / 34004
• FlyBaseID: FBgn0263133
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_078856.4
• Gene: EFL1 / 79631
• HGNCID: 25789
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 1073
• Identity: 207/1073 - (19%)
• Similarity: 341/1073 - (31%)
• Gaps: 424/1073 - (39%)

  Fly    37 KPIERIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSA 101
            |....||||.:.||:|.|||||.:.::...|.|:.  .:.||...   |||.|.|:.||||::|:
Human    14 KNTANIRNICVLAHVDHGKTTLADCLISSNGIISS--RLAGKLRY---MDSREDEQIRGITMKSS 73

  Fly   102 ATYTLWKDTN----INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYN 162
            |....:...|    ||:||:||||||:.||..|:|:.||.::|:.||.||..||..|.||....|
Human    74 AISLHYATGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLEN 138

  Fly   163 VPCLAFINKLDRL-----------GSNPYRVLSQMR--------SKMNHNAAFIQLPIGVESNCK 208
            :..:..|||:|||           .|:...:|.|:.        ||:....|..:....|..|.:
Human   139 IRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQVNPNSE 203

  Fly   209 ----------GIVDLVREKAIYFEGEHGMDIRLDEIP-QDMRVESLER--------RQELI---- 250
                      |:.| ..:..:||..|.|..:....|. ....:|...|        ::|::
Human   204 QGEQVYDWSTGLED-TDDSHLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLMKTL 267

  Fly   251 ----------EHLSNADETLG------ELFLE-----------------EKPFTEDDIKAALRRT 282
                      :.:...|:..|      :|.||                 :|..|...:|...|..
Human   268 WGDYYINMKAKKIMKGDQAKGKKPLFVQLILENIWSLYDAVLKKDKDKIDKIVTSLGLKIGAREA 332

  Fly   283 CINRTFTPVLVGTALKNKGVQPLLDAVL----DYLPNP-----GEVENLG--------------- 323
               |...|.:...|:.::.: |:..|||    ..||:|     ..||.|.
Human   333 ---RHSDPKVQINAICSQWL-PISHAVLAMVCQKLPSPLDITAERVERLMCTGSQTFDSFPPETQ 393

  Fly   324 -------------------FIEK----------------------------------------EG 329
                               |:.|                                        :|
Human   394 ALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQG 458

  Fly   330 QDPEKVVLNPARDGK-----------------------DPFVGLAFKLEAGRFGQLTYLRCYQGV 371
            |.|    |.|.:||.                       .|    ..:.|..:...:.:.|.:.||
Human   459 QAP----LEPTQDGSAIETCPKGEEPRGDEQQVESMTPKP----VLQEENNQESFIAFARVFSGV 515

  Fly   372 LRKGDNIFNARTN-------KKV--------------------RIARLVRLHSNQMEDVNEVYAG 409
            .|:|..||.....       ::|                    .:..|..|...::|.:.||..|
Human   516 ARRGKKIFVLGPKYSPLEFLRRVPLGFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPG 580

  Fly   410 DIFALFGVDCASGDTFTTNPKNNLSMESI--FVP-----EPVVSMAIKPNNTKDRDNFSKAIARF 467
            ::..:.|:     ..|........|:.|.  |:|     .|:|.:|::|.:..:.....|.:...
Human   581 NVLGIGGL-----QDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLL 640

  Fly   468 TKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYG-CPVTLGKPKVAFRETLVGPCEFDY 531
            .:.||..........:..||:. ||:||:.....::..:. ..:::.:|.:.||||:..|.:.|.
Human   641 NQADPCVQILIQETGEHVLVTA-GEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDM 704

  Fly   532 LHKKQSGGSGQYARIIGVME----------------------------------PLPPNQNTLLE 562
            ::::.  |..|...:|..|:                                  |||.....:||
Human   705 VNEEI--GKQQKVAVIHQMKEDQSKIPEGIQVDSDGLITITTPNKLATLSVRAMPLPEEVTQILE 767

  Fly   563 FVDETVGTNVPKQFVPGVEKG------YREMAE-----KGMLSGHKLSGIRF------------- 603
            ...:.:.:  .:|....:.:|      :::..|     ||.|..| |:|.|:
Human   768 ENSDLIRS--MEQLTSSLNEGENTHMIHQKTQEKIWEFKGKLEQH-LTGRRWRNIVDQIWSFGPR 829

  Fly   604 -------------------------------RLQDGGHHIVDSSELAFM---------------- 621
                                           |.:|.|:.||...:||.:
Human   830 KCGPNILVNKSEDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVL 894

  Fly   622 ---------------LAAHG------------------AIKEVFQNGSWQ--------------- 638
                           ||..|                  ...|.|:..:.|
Human   895 EKWDLSKFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSG 959

  Fly   639 --------------------ILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTEGTEG--WFTV 681
                                ::..:...::.|..:..|.|...||||.|.:...|..||  .|.:
Human   960 QLIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTDMFII 1024

  Fly   682 YAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRY 714
            .|.:|:.:.||:|.|:|..|.|.....:.:|.:
Human  1025 KAVLPVAESFGFADEIRKRTSGLASPQLVFSHW 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	FusA	38..731	CDD:440248	206/1072 (19%)
EFL1	NP_078856.4	PRK13351	1..1103	CDD:481252	207/1073 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..496		8/73 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	907..930		3/22 (14%)