DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and gfm1

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001073463.1	Gene:	gfm1 / 561840	ZFINID:	ZDB-GENE-061013-79	Length:	745	Species:	Danio rerio

Alignment Length:	742	Identity:	478/742 - (64%)
Similarity:	588/742 - (79%)	Gaps:	12/742 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRALKSLGKAGYSSHAKFSE-----------HKPIERIRNIGISAHIDSGKTTLTERILFYTGRI 69
            |||..||.:.....|:...:           ..|.||||||||||||||||||||||:|:|||||
Zfish     4 LRAASSLARLHRPGHSTLQQVLISCRSCSNGITPNERIRNIGISAHIDSGKTTLTERVLYYTGRI 68

  Fly    70 AEMHEVRGKDNVGATMDSMELERQRGITIQSAATYTLWKDTNINIIDTPGHVDFTVEVERALRVL 134
            ||||||||||.|||.|||||||||||||||||||||:||:.||||||||||||||:||||:||||
Zfish    69 AEMHEVRGKDGVGAIMDSMELERQRGITIQSAATYTMWKNHNINIIDTPGHVDFTIEVERSLRVL 133

  Fly   135 DGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCLAFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQL 199
            ||||||||||||||.||:|||||||||:||.|.|||||||||:||.|.|.|:|:|:|.||||:.:
Zfish   134 DGAVLVLCAVGGVQCQTVTVNRQMKRYSVPFLTFINKLDRLGANPNRALQQLRTKLNQNAAFVNI 198

  Fly   200 PIGVESNCKGIVDLVREKAIYFEGEHGMDIRLDEIPQDMRVESLERRQELIEHLSNADETLGELF 264
            |||:|.|.:||:||:.|::|.|:|..|..:|.::||.:||.|:.:|||||:|.::||||||||:|
Zfish   199 PIGLEGNLRGIIDLIEERSIVFDGPFGESVRYEDIPPEMRSEAADRRQELVECVANADETLGEMF 263

  Fly   265 LEEKPFTEDDIKAALRRTCINRTFTPVLVGTALKNKGVQPLLDAVLDYLPNPGEVENLGFIEKEG 329
            |||:..|..|:|||:||..:.|:|:|||||:|||||||||||||||:|||||.||:|...:.:||
Zfish   264 LEERVPTVLDLKAAVRRATVKRSFSPVLVGSALKNKGVQPLLDAVLEYLPNPTEVQNYAILNEEG 328

  Fly   330 Q-DPEKVVLNPARDGKDPFVGLAFKLEAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRIARLV 393
            : :..|::::..||...|||||||||||||||||||:|.|||.|||.|.|.|:||.::||:.|||
Zfish   329 ESEGSKILMDSTRDDTQPFVGLAFKLEAGRFGQLTYVRVYQGCLRKTDYIHNSRTGRRVRVQRLV 393

  Fly   394 RLHSNQMEDVNEVYAGDIFALFGVDCASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPNNTKDRD 458
            |||::|||||...|||||.||||:|||||||||.....|||||||.|||||:||||:|:|..|.|
Zfish   394 RLHADQMEDVEVAYAGDICALFGIDCASGDTFTARNNANLSMESIHVPEPVISMAIRPSNKNDTD 458

  Fly   459 NFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYGCPVTLGKPKVAFRETL 523
            ..||.|:|||:|||||...||.:.|||::|||||||||||:|||||||.||..:|||||||||||
Zfish   459 KLSKGISRFTREDPTFRVHFDTESKETIISGMGELHLEIYSQRMEREYSCPCVMGKPKVAFRETL 523

  Fly   524 VGPCEFDYLHKKQSGGSGQYARIIGVMEPLPPNQNTLLEFVDETVGTNVPKQFVPGVEKGYREMA 588
            .....|:|.|||||||||||.::|||:|||.....|.:||.|||||||:||||||.||||:|:..
Zfish   524 TSAVPFEYTHKKQSGGSGQYGKVIGVLEPLDSENYTKVEFSDETVGTNIPKQFVPAVEKGFRDAC 588

  Fly   589 EKGMLSGHKLSGIRFRLQDGGHHIVDSSELAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEE 653
            |||.|.|||:||:||.|:||.||:|||:|::|:.|..||:|:..:..:..||||:|.||:.||.|
Zfish   589 EKGPLIGHKISGVRFVLEDGAHHMVDSNEISFIRAGEGAVKQALEKATVVILEPVMSVEIVAPNE 653

  Fly   654 FQGAVMGHLSKRHGIITGTEGTEGWFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCL 718
            |||||:..:::|||:|:|.:|.:|:||:||::|||||||||.||||.|:||||:|||||||.||.
Zfish   654 FQGAVIAGVNRRHGVISGQDGADGYFTLYADIPLNDMFGYATELRSCTEGKGEYTMEYSRYQPCA 718

  Fly   719 PDVQDQIVRQYQESQGLAQPDKKKKKN 745
            ..||:.:|.::.|:.|.....|.|.||
Zfish   719 ASVQEDLVNKHLEATGQLPAKKSKWKN 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	201/271 (74%)
		PRK12740	48..727	CDD:237186	456/679 (67%)
		mtEFG1_II_like	347..427	CDD:293908	60/79 (76%)
		EFG_III	441..516	CDD:293919	50/74 (68%)
		EFG_mtEFG1_IV	519..636	CDD:238715	70/116 (60%)
		mtEFG1_C	641..718	CDD:239764	50/76 (66%)
gfm1	NP_001073463.1	EF-G	43..315	CDD:206673	201/271 (74%)
		PRK12740	47..726	CDD:237186	456/678 (67%)
		mtEFG1_II_like	347..427	CDD:293908	60/79 (76%)
		EFG_III	441..516	CDD:293919	50/74 (68%)
		EFG_mtEFG1_IV	519..635	CDD:238715	70/115 (61%)
		mtEFG1_C	641..718	CDD:239764	50/76 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582919
Domainoid	1	1.000	419	1.000	Domainoid score	I621
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6449
Inparanoid	1	1.050	979	1.000	Inparanoid score	I296
OMA	1	1.010	-	-		QHG62898
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	1	1.000	-	-		FOG0003241
OrthoInspector	1	1.000	-	-		oto41259
orthoMCL	1	0.900	-	-		OOG6_100770
Panther	1	1.100	-	-	LDO	PTHR43636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R368
SonicParanoid	1	1.000	-	-		X2192
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800