DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and gfm2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001071013.1	Gene:	gfm2 / 558184	ZFINID:	ZDB-GENE-060201-3	Length:	762	Species:	Danio rerio

Alignment Length:	774	Identity:	256/774 - (33%)
Similarity:	398/774 - (51%)	Gaps:	75/774 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLITRLLTG------NNTLRLRALKSLGKAGYS------SHAKFSEHKPIERIRNIGISAHIDS 53
            :||...:|.|      |.:|:....:...|..||      ...:...:..|.:||||||.||||:
Zfish     3 LSLTFPVLRGCTGHLVNRSLQAPRWRVTWKRSYSLLQDEVKSLRTVVNPDISKIRNIGIMAHIDA 67

  Fly    54 GKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSAATYTLWKDTNINIIDTP 118
            ||||.|||:|:|:|....:.:|...|.|   .|.|..||:|||||||||....|||..||:||||
Zfish    68 GKTTTTERMLYYSGYTRALGDVDDGDTV---TDYMAQERERGITIQSAAVTFDWKDYRINLIDTP 129

  Fly   119 GHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCLAFINKLDRLGSNPYRVL 183
            ||||||:|||||||||||||.|..|..||::||:||.||.:::.:||:.|:||:|:..::....|
Zfish   130 GHVDFTLEVERALRVLDGAVAVFDASAGVEAQTMTVWRQAEKHQIPCVCFLNKMDKPAASLRYSL 194

  Fly   184 SQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIYFEG----EHGMDIRLDEI-PQD---MRV 240
            ..:::|:..|...:|:|||...:..|:|||:..:.:.::|    ..|....::.: |.|   :.:
Zfish   195 DSIKAKLKANPVLLQIPIGSGKSFTGLVDLITRQKMMWQGNALTNDGRSFEINSLQPSDDPNVLL 259

  Fly   241 ESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKA-----ALRRTCINRTFTPVLVGTALKNK 300
            ...|.|..|||.:::.|:...||.|.|.....|.:.|     |:||..:.|...|||.|::||||
Zfish   260 AVSEARAALIEQVADLDDEFAELLLGEYGENFDAVPAVKLQEAVRRVTLARKGVPVLCGSSLKNK 324

  Fly   301 GVQPLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFK-LEAGRFGQLTY 364
            ||||||||:..|||.|.|..:                :..|..|:....|||| :...:.|.|.:
Zfish   325 GVQPLLDAITAYLPAPNERNH----------------DLVRWYKNDLCALAFKVVHDKQRGPLVF 373

  Fly   365 LRCYQGVLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVNEVYAGDIFALFGV-DCASGDTFTTN 428
            :|.|.|.::...::.|...|:..:::||:...::|..::..:.||:|....|: ...:|||..::
Zfish   374 VRIYSGSMKAQSSVHNINRNETEKMSRLLLPFADQQIEIPSLSAGNIALTVGLKQTVTGDTIVSS 438

  Fly   429 P-------------------KNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTF 474
            .                   .::.::..:.|||||...:|:|.....:.:...|:....:|||:.
Zfish   439 KASAAAAIRRAQAEAESMSNSHSAALAGVEVPEPVFFCSIEPPTMAKQADLEHALNCLQREDPSL 503

  Fly   475 HFFFDNDVKETLVSGMGELHLEIYAQRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGG 539
            ....|.|..:|::.||||||:||...|::|||.....||..:||:|||::.......|..:..|.
Zfish   504 KVRIDPDSGQTVLCGMGELHIEIIHDRIKREYKIETHLGPLQVAYRETILQSVTAKDLLDRILGE 568

  Fly   540 SGQYARIIGVMEPLPPNQNTLLEFV-DETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRF 603
            ......:...:.||..|.:...:.. :|.|...:|......||.|.:....:|.:.|..:.|::.
Zfish   569 KRHVVSVELTVHPLKENSSASCDITFEEDVKAMLPADVREAVENGVQSAYLQGPVLGFPVQGVQT 633

  Fly   604 RLQDGGHHIVDSSELAFMLAA---HGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKR 665
            .:||..   ::|...|.|::|   ...:|.:.|.|. |:|||:|.:|||..||...:|:..||:|
Zfish   634 VIQDVR---LESGTSAAMVSACVSRCMLKALKQAGG-QVLEPVMALEVTVGEEHLSSVLADLSQR 694

  Fly   666 HGIITGTEGTEGWFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPDVQDQ 724
            .|.|...:..:....:.|:|||.:|.||:..||:.|.|...|::|.|.|.|.  :.|||
Zfish   695 RGTICDIQSRQDNKILLADVPLAEMMGYSTVLRTLTSGNATFSLELSSYEPM--NSQDQ 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	128/284 (45%)
		PRK12740	48..727	CDD:237186	240/715 (34%)
		mtEFG1_II_like	347..427	CDD:293908	21/81 (26%)
		EFG_III	441..516	CDD:293919	27/74 (36%)
		EFG_mtEFG1_IV	519..636	CDD:238715	25/120 (21%)
		mtEFG1_C	641..718	CDD:239764	30/76 (39%)
gfm2	NP_001071013.1	PRK12739	52..760	CDD:237185	247/725 (34%)
		EF-G	58..340	CDD:206673	128/284 (45%)
		mtEFG2_II_like	355..437	CDD:293909	21/81 (26%)
		EFG_III	470..545	CDD:293919	27/74 (36%)
		mtEFG2_like_IV	546..665	CDD:238842	27/121 (22%)
		EFG_mtEFG_C	670..746	CDD:239683	29/75 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920