DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and mIF2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	641	Identity:	143/641 - (22%)
Similarity:	213/641 - (33%)	Gaps:	237/641 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQ-SAATYTLWK 108
            :.:..|:|.|||||             :..:||.|        :......|||.. .|.|.||..
  Fly   165 VTVMGHVDHGKTTL-------------LDSLRGAD--------VAAGEAGGITQHIGAFTVTLEN 208

  Fly   109 DTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCLAFINKLD 173
            ...:..:|||||..|:....|.....|..|||:.|..||.:||..|.:..|...||.:..:||:|
  Fly   209 GERVTFLDTPGHAAFSAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVPIIVALNKID 273

  Fly   174 RLGSN---PYRVLSQMRSKMNHNAAFIQ-LPIGV--ESNCKGIVDLVREKAIYFEGEHGMDIRLD 232
            :..:|   ..|.|:||...:..:...:| :||..  .:|.:.:.:.|..:|..      |.::.|
  Fly   274 KPEANIEKSKRELAQMGLALEEHGGDVQVIPISALKGTNLELLAEAVSTQATL------MGLKAD 332

  Fly   233 EIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTA- 296
              |..: ||.:     ::|  |..|...|:|      .|....:..||:..:      :|.|.|
  Fly   333 --PTGL-VEGI-----VVE--SKTDPRRGKL------STAIVSRGTLRKGSV------LLSGLAH 375

  Fly   297 LKNKGV-----QPLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFKLEA 356
            .|.:|:     |||.:|     |....||.||:.|                     :.||
  Fly   376 AKVRGLFDHNGQPLSEA-----PPGTPVEILGWRE---------------------LPLA----- 409

  Fly   357 GRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVNEVYAGDI---------- 411
                              ||.|....|.||.......|.|.:|.|.: |..:.:|
  Fly   410 ------------------GDLILEVETEKKAHAVLKYREHESQQEKI-ESSSDEIRKKEEEHQAK 455

  Fly   412 -------------FALFG------VDCASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPNNTKDR 457
                         |.:.|      ||...|                   :|.||:.||    .|.
  Fly   456 YRAEREARRLAGRFRMRGGQRVKQVDENEG-------------------KPRVSVIIK----GDV 497

  Fly   458 DNFSKAIARFTKEDPTFHFFFDNDVKETLVS-----------GMGEL-----------HLEIYAQ 500
            ....:||.               ||.||..|           |:|.:           |..|||.
  Fly   498 HGSVEAIL---------------DVLETYNSNESCRLDIVHYGVGNVTEGDLELAKAFHAIIYAF 547

  Fly   501 RMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGSGQYARIIGVMEPLPPNQNTLLEFVD 565
            .:|    .|......:|..|...:.....|.|.::.|             ..|||.:      |:
  Fly   548 AVE----TPQLKAAKEVNIRSYNIIYRLIDDLKEQLS-------------SKLPPVE------VE 589

  Fly   566 ETVG-TNVPKQFVPGVEKGYREM------AEKGMLSGHKLSGIRFRLQDGGHHIVD 614
            |.:| .||.:.|:  :.:|.:|:      ..||:|.    ...:|||...|..:.|
  Fly   590 EVLGEANVLQNFL--INEGRKEVPVAGCRCTKGVLK----KAQKFRLLRDGEVVYD 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	74/283 (26%)
		PRK12740	48..727	CDD:237186	143/638 (22%)
		mtEFG1_II_like	347..427	CDD:293908	19/108 (18%)
		EFG_III	441..516	CDD:293919	21/96 (22%)
		EFG_mtEFG1_IV	519..636	CDD:238715	23/103 (22%)
		mtEFG1_C	641..718	CDD:239764
mIF2	NP_651621.2	InfB	158..689	CDD:223606	143/641 (22%)
		IF2_eIF5B	163..327	CDD:206674	51/188 (27%)
		IF2_mtIF2_II	336..431	CDD:293903	34/163 (21%)
		IF-2	482..575	CDD:288813	25/134 (19%)
		mtIF2_IVc	593..680	CDD:293893	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930