DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and eIF2gamma

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	87/435 - (20%)
Similarity:	146/435 - (33%)	Gaps:	144/435 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQ-SAATYTLW 107
            |||...|:..||:|:.:       .|:.:..||.|:           |.:|.|||: ..|...::
  Fly    42 NIGTIGHVAHGKSTVVK-------AISGVQTVRFKN-----------ELERNITIKLGYANAKIY 88

  Fly   108 KDTN------------------------------------INIIDTPGHVDFTVEVERALRVLDG 136
            |..|                                    ::.:|.|||......:.....|:|.
  Fly    89 KCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDA 153

  Fly   137 AVLVL-----CAVGGVQSQT---LTVNRQMKRYNVPCLAFINKLDRLGSNPYRVLSQMRSKMNHN 193
            |:|::     |.    |.||   |.....||...:  |...||:|.:..      ||.:.:....
  Fly   154 ALLLIAGNESCP----QPQTSEHLAAIEIMKLKQI--LILQNKIDLIKE------SQAKEQYEEI 206

  Fly   194 AAFIQ---------LPIGVESNCKGIVDLVREKAIYFEGEHGMDIRLDEIPQDMRVESLERRQEL 249
            ..|:|         :||..:  .|..:|::.|..:            ::||...|..:...|..:
  Fly   207 TKFVQGTVAEGAPIIPISAQ--LKYNIDVLCEYIV------------NKIPVPPRDFNAPPRLIV 257

  Fly   250 IEHLSNADETLGELFLEEKPFTE-DDIKAALRRTCINRTFTPVL-VGTALK------------NK 300
            |..           |...||..| .|:|..:....|   .:.|| ||..::            |.
  Fly   258 IRS-----------FDVNKPGCEVADLKGGVAGGSI---LSGVLKVGQEIEVRPGVVTKDSDGNI 308

  Fly   301 GVQPLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFKLEAGRFGQLTYL 365
            ..:|:...::.......|::   :....|.......::|.....|..||...    |..|||..:
  Fly   309 TCRPIFSRIVSLFAEQNELQ---YAVPGGLIGVGTKIDPTLCRADRLVGQVL----GAVGQLPDI 366

  Fly   366 RCYQG------VLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVN 404
              ||.      :||:   :...||:...:.||:.:|..|::..||
  Fly   367 --YQELEISYYLLRR---LLGVRTDGDKKGARVEKLQKNEILLVN 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	65/339 (19%)
		PRK12740	48..727	CDD:237186	84/431 (19%)
		mtEFG1_II_like	347..427	CDD:293908	18/64 (28%)
		EFG_III	441..516	CDD:293919
		EFG_mtEFG1_IV	519..636	CDD:238715
		mtEFG1_C	641..718	CDD:239764
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	87/435 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930