DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and eftud2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_956802.2	Gene:	eftud2 / 393480	ZFINID:	ZDB-GENE-040426-1569	Length:	973	Species:	Danio rerio

Alignment Length:	831	Identity:	188/831 - (22%)
Similarity:	317/831 - (38%)	Gaps:	229/831 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ERIRNIGISAHIDSGKTTLTERILFYTGRIAEMH-EVRGKDNVGAT-MDSMELERQRGITIQSAA 102
            |.|||:.:..|:..|||...:.:      |.:.| |:|.:|:.... .|.:..|::||:.|:|..
Zfish   128 ELIRNVTLCGHLHHGKTCFVDCL------IEQTHPEIRKRDDEDLRYTDILFTEQERGVGIKSTP 186

  Fly   103 TYTLWKDTN-----INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYN 162
            ...:..|:.     .||:||||||:|:.||..|:|:.||.||.:.|..||...|..:.:...:..
Zfish   187 VTMVLPDSRGKSYLFNIMDTPGHVNFSDEVTSAVRLSDGIVLFIDAAEGVMLNTERLIKHAVQER 251

  Fly   163 VPCLAFINKLDRL-------GSNPYRVLSQMRSKMN------------------HNAAF------ 196
            :.....|||:|||       .::.|..|..:..::|                  .|..|
Zfish   252 LAITICINKIDRLIVELKLPPTDAYYKLRHIVDEVNGLLSTYSTDESLIVSPLLGNVCFASSQYC 316

  Fly   197 IQLPIG----VESNCKGIVDLVREKA------IYFEGEHGMDIR--------------------- 230
            |...:|    :.|:..|.:..: |.|      |||..:.....:
Zfish   317 ICFTLGSFAKIYSDTYGDISYM-EFAKRLWGDIYFNPKTRKFTKKAPNSNSQRSFVEFVLEPLYK 380

  Fly   231 -LDEIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVG 294
             |.::..|:.........||..||     |..||.|..||.        ||..| ||.|.. ..|
Zfish   381 ILSQVVGDVDTSLPRVLDELGIHL-----TKEELKLNIKPL--------LRLVC-NRFFGE-FTG 430

  Fly   295 TALKNKGVQPLLDAVLDYLPNP-----GEVEN--LGFIEKE-GQ-----DPEKVVLNPARDGKDP 346
                      |:|..:.::|:|     .::|:  .|.::.: |:     ||:..::.........
Zfish   431 ----------LVDMCVQHIPSPQGGARAKIEHTYTGGLDSDLGETMSECDPDGPLMCHTTKMYST 485

  Fly   347 FVGLAFKLEAGRFGQLTYLRCYQGVLRKGDNI------FNARTNKKVRIARLVRLHSN----QME 401
            ..|:.|.    .||     |...|.|:.|..:      ::....:..:|..:.||..:    |:|
Zfish   486 DDGVQFH----AFG-----RVLSGTLQAGQPVKVLGENYSLEDEEDSQICTVGRLWISVARYQIE 541

  Fly   402 DVNEVYAGDIFALFGVDCASGDTFT-TNPKNNLSMESIFVP-----EPVVSMAIKPNNTKDRDNF 460
             ||.|.||:...:.|.|.....|.| |.|:.|...: ||.|     ..|:.:|::|.|..:....
Zfish   542 -VNRVPAGNWVLIEGCDQPIVKTATITEPRGNEEAQ-IFRPLKFNTASVIKIAVEPVNPSELPKM 604

  Fly   461 SKAIARFTKEDPTFHFFFDNDVKET---LVSGMGELHLEIYAQRMEREYG-CPVTLGKPKVAFRE 521
            ...:.:..|..|:    ....|:|:   ::.|:|||:|:.....:.:.|. ..:.:..|.|.|.|
Zfish   605 LDGLRKVNKSYPS----LTTKVEESGEHVILGIGELYLDCVMHDLRKMYSEIDIKVADPVVTFCE 665

  Fly   522 TLVG----PCEFDYLHKKQSGGSGQYARIIGVMEPLPP---------------NQNTLLEF---- 563
            |:|.    .|..:..:||.        :|..:.|||..               |:..|.||
Zfish   666 TVVETSSLKCFAETPNKKN--------KITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTK 722

  Fly   564 ------------------------VDETVGTNVPKQFVPGVE----KGYREMAEKGMLSGHKLSG 600
                                    ||:|:.:.|.|..:..|:    :|::....:|.|....:..
Zfish   723 YDWDLLAARSIWAFGPDTTGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDEPIRN 787

  Fly   601 IRFRLQD----------GGHHIVDSSELAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQ 655
            ::|::.|          ||..::.:        |...:...|...:.:::||...|||.||.:..
Zfish   788 VKFKILDAVIAQEPLHRGGGQVIPT--------ARRVVYSAFLMATPRLMEPYYFVEVQAPADCV 844

  Fly   656 GAVMGHLSKRHGIITGTEGTEG--WFTVYAEVPLNDMFGYAGELRSSTQGK 704
            .||...|::|.|.:|......|  .:|:.|.:|..|.||:..:||:.|||:
Zfish   845 SAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQ 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	80/341 (23%)
		PRK12740	48..727	CDD:237186	184/823 (22%)
		mtEFG1_II_like	347..427	CDD:293908	22/90 (24%)
		EFG_III	441..516	CDD:293919	15/83 (18%)
		EFG_mtEFG1_IV	519..636	CDD:238715	30/177 (17%)
		mtEFG1_C	641..718	CDD:239764	25/66 (38%)
eftud2	NP_956802.2	EFTUD2	4..111	CDD:292623
		PTZ00416	123..955	CDD:240409	188/831 (23%)
		Snu114p	131..329	CDD:206730	52/203 (26%)
		EF2_II_snRNP	475..568	CDD:293907	22/102 (22%)
		snRNP_III	587..658	CDD:293921	14/74 (19%)
		EF2_IV_snRNP	658..835	CDD:238840	34/192 (18%)
		eEF2_C_snRNP	830..909	CDD:239765	25/66 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810