DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and eEFSec

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_611584.1	Gene:	eEFSec / 37444	FlyBaseID:	FBgn0034627	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	110/557 - (19%)
Similarity:	193/557 - (34%)	Gaps:	178/557 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGIT---------IQ 99
            |||:..|:|||||||.:.:...:..              |..|......:||||         :.
  Fly     6 NIGLLGHVDSGKTTLAKALSSISST--------------AAFDKNPQSVERGITLDLGFSGLLVD 56

  Fly   100 SAATYTLWKDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQT---LTVNRQMKRY 161
            :.|.....:......:|.|||......:....:::|..:||:.|..|.|:||   |.:...:::
  Fly    57 APAHLPQGEQLQFTFVDCPGHASLIRTIIGGAQIIDLMLLVVDAQKGKQTQTAECLIIGELLQK- 120

  Fly   162 NVPCLAFINKLDRLGSNPYRVLSQMRSKMNHNAAFI-----------QLPIGVESNCKG-----I 210
              ..:..|||:|....|      |..||:......:           |:||...|..:|     :
  Fly   121 --KLIVVINKIDVYPEN------QRASKLEKLRLRLAKTLEATTFGGQVPICAVSALQGTHIAEL 177

  Fly   211 VDLVREKAIYFEGEHGMD----------------------------------IRLDEIPQDMRVE 241
            .:::||  .||:.:..:.                                  |.|..:.:..:|:
  Fly   178 REVLRE--AYFQPQRNLADPLFMYVDHCFGIKGQGTVCTGTLLQGKVQVNNVIELPALGEQRKVK 240

  Fly   242 SLERRQELIEHLSNAD-------------------------ETLGELFLEEKP--FTEDDIKAAL 279
            |::..::.:...|..|                         :.:..:.|:.||  :.::.|| ::
  Fly   241 SIQMFRKNVTSASMGDRIGLCVTQFNAKLLERGIITQPGYLKPIYAVCLQFKPIRYYKEVIK-SM 304

  Fly   280 RRTCINRTFTPVLVGTAL--KNKGVQPL--LDAVLDYLPN--PGEVEN-------LGFIEKEGQD 331
            |:..|:.....|:....|  ...|....  ||...:|:.:  |.||::       |.|
  Fly   305 RKMHISVGHNTVMANVTLFRDTDGTTSTFQLDKEYEYMEDVQPAEVQHNDVIYALLQF------- 362

  Fly   332 PEKVVLNPARDGKDPFVGLAFKLEA------------GRFGQLTY-LRCYQGVLRKGDNIFNART 383
             |..||:|...     ..:|.||:.            ||....|: .:.:|..|.| ..||. |.
  Fly   363 -ESPVLSPPHS-----TLIASKLDMDVHSTSCRLAFWGRIAWQTHSSKYFQEELPK-LRIFK-RK 419

  Fly   384 NKKVRIARLVR----LHSNQMEDV-NEVYAGDIFALFGVDCASGD------TFTTNPKNNLSMES 437
            .|...|.|:|.    :..|..:|. .::|.|.     .|:.::|:      ||....|..::.:.
  Fly   420 QKVGSIQRVVNSSEVIVQNLFKDAKRDLYVGK-----NVELSTGEKGRIERTFGQTSKVAITFQD 479

  Fly   438 IFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTF 474
            ...||.:.::    .|.|...|..|.:  |.|:...|
  Fly   480 ALSPETISNV----KNVKVLLNCKKYV--FNKQAGLF 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	67/366 (18%)
		PRK12740	48..727	CDD:237186	107/553 (19%)
		mtEFG1_II_like	347..427	CDD:293908	24/103 (23%)
		EFG_III	441..516	CDD:293919	9/34 (26%)
		EFG_mtEFG1_IV	519..636	CDD:238715
		mtEFG1_C	641..718	CDD:239764
eEFSec	NP_611584.1	SelB_euk	5..192	CDD:206676	48/210 (23%)
		SelB	6..467	CDD:225815	98/506 (19%)
		SelB_II	196..278	CDD:293897	6/81 (7%)
		eSelB_III	283..396	CDD:294009	26/126 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930