DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and Eef2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_058941.1	Gene:	Eef2 / 29565	RGDID:	61979	Length:	858	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	211/856 - (24%)
Similarity:	341/856 - (39%)	Gaps:	187/856 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGAT--MDSMELERQRGITIQSAATY 104
            |||:.:.||:|.||:|||:.::...|.||..       ..|.|  .|:.:.|::|.|||:|.|..
  Rat    19 IRNMSVIAHVDHGKSTLTDSLVCKAGIIASA-------RAGETRFTDTRKDEQERCITIKSTAIS 76

  Fly   105 TLWK----DTN------------INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLT 153
            ..::    |.|            ||:||:||||||:.||..||||.|||::|:..|.||..||.|
  Rat    77 LFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTET 141

  Fly   154 VNRQMKRYNVPCLAFINKLDR----LGSNPYRVLSQMRSKMNHNAAFIQLPIGV-ESNCKG--IV 211
            |.||.....:..:..:||:||    |...| ..|.|...::..|...|....|. ||...|  ::
  Rat   142 VLRQAIAERIKPVLMMNKMDRALLELQLEP-EELYQTFQRIVENVNVIISTYGEGESGPMGNIMI 205

  Fly   212 DLVREKAIYFEGEHGMDIRLDEIPQDMRVESLERRQE----LIEHLSNADETLGELFLE------ 266
            |.|.....:..|.||....|.:. .:|.|.....:.|    ..|.....::.:.:|:.:
  Rat   206 DPVLGTVGFGSGLHGWAFTLKQF-AEMYVAKFAAKGEGQLGAAERAKKVEDMMKKLWGDRYFDPA 269

  Fly   267 ----EKPFTEDDIKAALRRTC------INRTFTPVL-----------------VGTALKNKGVQP 304
                .|.....|.|...|..|      |.:.|..::                 :.:..|:|..:|
  Rat   270 NGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDIKLDSEDKDKEGKP 334

  Fly   305 LLDAVLD---------------YLPNP--GEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAF 352
            ||.||:.               :||:|  .:......:.:...|.|..:...:.|.|.|.:....
  Rat   335 LLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYIS 399

  Fly   353 KL----EAGRFGQLTYLRCYQGVLRKGDNIF----NARTNKK-----VRIARLVRLHSNQMEDVN 404
            |:    :.|||  ..:.|.:.||:..|..:.    |....||     ..|.|.:.:....:|.:.
  Rat   400 KMVPTSDKGRF--YAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIE 462

  Fly   405 EVYAGDIFALFGVD---CASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIAR 466
            :|..|:|..|.|||   ..:|...|....:|:.:.. |...|||.:|::..|..|.....:.:.|
  Rat   463 DVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMK-FSVSPVVRVAVEAKNPADLPKLVEGLKR 526

  Fly   467 FTKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYGC-PVTLGKPKVAFRETLVGPCEFD 530
            ..|.||......: :..|.:::|.|||||||..:.:|.::.| |:....|.|::|||:.......
  Rat   527 LAKSDPMVQCIIE-ESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVL 590

  Fly   531 YLHKKQSGGSGQYARI---------------IGVMEPLPPNQNTLLE--------------FVDE 566
            .|.|..:..:..|.:.               :...:.|......|.|              |..:
  Rat   591 CLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAEARKIWCFGPD 655

  Fly   567 TVGTNVPKQFVPGVE----------KGYREMAEKGMLSGHKLSGIRFRLQD----------GGHH 611
            ..|.|:......||:          .|::...::|.|....:.|:||.:.|          ||..
  Rat   656 GTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQ 720

  Fly   612 IVDSSE---LAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTE 673
            |:.::.   .|.:|.|..           :::|||.|||:..||:..|.:.|.|:::.|.:....
  Rat   721 IIPTARRCLYASVLTAQP-----------RLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEES 774

  Fly   674 GTEG--WFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPD-----VQDQIVRQYQE 731
            ...|  .|.|.|.:|:|:.||:..:|||:|.|:.        :..|:.|     ..|......:.
  Rat   775 QVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQA--------FPQCVFDHWQILPGDPFDNSSRP 831

  Fly   732 SQGLAQPDKKK 742
            ||.:|:..|:|
  Rat   832 SQVVAETRKRK 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	94/348 (27%)
		PRK12740	48..727	CDD:237186	203/833 (24%)
		mtEFG1_II_like	347..427	CDD:293908	22/95 (23%)
		EFG_III	441..516	CDD:293919	22/75 (29%)
		EFG_mtEFG1_IV	519..636	CDD:238715	27/168 (16%)
		mtEFG1_C	641..718	CDD:239764	25/78 (32%)
Eef2	NP_058941.1	PTZ00416	1..858	CDD:240409	211/856 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810