DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and Eftud2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_038943695.1	Gene:	Eftud2 / 287739	RGDID:	1560116	Length:	972	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	178/844 - (21%)
Similarity:	316/844 - (37%)	Gaps:	226/844 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ERIRNIGISAHIDSGKTTLTERILFYTGRIAEMH-EVRGK-DNVGATMDSMELERQRGITIQSAA 102
            |.|||:.:..|:..|||...:.:      |.:.| |:|.: |......|.:..|::||:.|:|..
  Rat   127 ELIRNVTLCGHLHHGKTCFVDCL------IEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTP 185

  Fly   103 TYTLWKDTN-----INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYN 162
            ...:..||.     .||:||||||:|:.||...||:.||.||.:.|..||...|..:.:...:..
  Rat   186 VTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQER 250

  Fly   163 VPCLAFINKLDRL-------GSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIY 220
            :.....|||:|||       .::.|..|..:..::|   ..|.: ...:.|.  |:..:.....:
  Rat   251 LAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVN---GLISM-YSTDENL--ILSPLLGNVCF 309

  Fly   221 FEGEHGMDIRLDEIPQ-------DMRVESLERRQELIEHLSNADETLGELFLEEK--PFTEDDIK 276
            ...::.:...|....:       |:..:...:|            ..|:::...|  .||:....
  Rat   310 SSSQYSICFTLGSFAKIYADTFGDINYQEFAKR------------LWGDIYFNPKTRKFTKKAPS 362

  Fly   277 AALRRTCINRTFTPVL---------VGTALKNK---------------GVQPLL----------- 306
            ::.:|:.:.....|:.         |.|:|...               .::|||
  Rat   363 SSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEF 427

  Fly   307 ----DAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFK-------------- 353
                |..:.::|:|          |.|..|:  :.:....|.|..:|.|..
  Rat   428 TGFVDMCVQHIPSP----------KVGAKPK--IEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK 480

  Fly   354 -------LEAGRFGQLTYLRCYQG----VLRKGDNIFNARTNKKVRIARL----VRLHSNQMEDV 403
                   ::...||::.....:.|    ||.:...:.:...::...:.||    .|.|.    :|
  Rat   481 MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHI----EV 541

  Fly   404 NEVYAGDIFALFGVDCASGDTFT-TNPKNNLSMESIFVP-----EPVVSMAIKPNNTKDRDNFSK 462
            |.|.||:...:.|||.....|.| |.|:.|...: ||.|     ..|:.:|::|.|..:......
  Rat   542 NRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQ-IFRPLKFNTTSVIKIAVEPVNPSELPKMLD 605

  Fly   463 AIARFTKEDPTFHFFFDNDVKET---LVSGMGELHLEIYAQRMEREYG-CPVTLGKPKVAFRETL 523
            .:.:..|..|:    ....|:|:   ::.|.|||:|:.....:.:.|. ..:.:..|.|.|.||:
  Rat   606 GLRKVNKSYPS----LTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETV 666

  Fly   524 VG----PCEFDYLHKKQSGGSGQYARIIGVMEPLPP---------------NQNTLLEF------ 563
            |.    .|..:..:||.        :|..:.|||..               |:..|.||
  Rat   667 VETSSLKCFAETPNKKN--------KITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYD 723

  Fly   564 ----------------------VDETVGTNVPKQFVPGVE----KGYREMAEKGMLSGHKLSGIR 602
                                  ||:|:.:.|.|..:..|:    :|::....:|.|....:..::
  Rat   724 WDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVK 788

  Fly   603 FRLQD----------GGHHIVDSSELAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGA 657
            |::.|          ||..|:.:        |...:...|...:.:::||...|||.||.:...|
  Rat   789 FKILDAVVAQEPLHRGGGQIIPT--------ARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSA 845

  Fly   658 VMGHLSKRHGIITGTEGTEG--WFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLP 719
            |...|::|.|.:|......|  .:|:.|.:|..|.||:..:||:.|||:. |::....:...:|
  Rat   846 VYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQA-FSLSVFHHWQIVP 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	68/333 (20%)
		PRK12740	48..727	CDD:237186	174/836 (21%)
		mtEFG1_II_like	347..427	CDD:293908	21/109 (19%)
		EFG_III	441..516	CDD:293919	15/83 (18%)
		EFG_mtEFG1_IV	519..636	CDD:238715	31/177 (18%)
		mtEFG1_C	641..718	CDD:239764	26/78 (33%)
Eftud2	XP_038943695.1	EFTUD2	4..110	CDD:406414
Eftud2	XP_038943695.1	FusA	122..954	CDD:357662	178/844 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810