DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and SPBC660.10

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_595089.1	Gene:	SPBC660.10 / 2541108	PomBaseID:	SPBC660.10	Length:	813	Species:	Schizosaccharomyces pombe

Alignment Length:	807	Identity:	249/807 - (30%)
Similarity:	382/807 - (47%)	Gaps:	167/807 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KFSEHKPIERIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGI 96
            ::..:..|..|||:||.||||:|||||||::|:|.|..:....|...|.|   ||.:..||||||
pombe    18 RYQSNISINSIRNVGIIAHIDAGKTTLTEKMLYYGGFTSHFGNVDTGDTV---MDYLPAERQRGI 79

  Fly    97 TIQSAATYTLWKDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRY 161
            ||.|||....|::..||:||||||.|||.||||::.||||||.::....||::||..|.:|..:.
pombe    80 TINSAAISFTWRNQRINLIDTPGHADFTFEVERSVAVLDGAVAIIDGSAGVEAQTKVVWKQATKR 144

  Fly   162 NVPCLAFINKLDRLGSN--------------PYRVLSQMRSKMNHNAAFIQLPI---GV-ESNCK 208
            .:|.:.|:||:||:||:              ||.::             :|||:   |: |....
pombe   145 GIPKVIFVNKMDRVGSSLGSTIRSIYTNLDCPYPLV-------------LQLPVYSDGLQERKFL 196

  Fly   209 GIVDLVREKAIYFE------GEHGMDIRLDEIPQDMRVESLERRQELIEHLSNADETLGELFLEE 267
            ||:|::::|.|.::      |..|..::...||:......:|.|..|:..|.:.||||.:.:||.
pombe   197 GILDILQQKMILWDTSDNKLGTDGTHVQELPIPESHMERFIEARNALVMSLCDVDETLCDEYLEN 261

  Fly   268 K---PFTEDDIKAALRRTCINRTFTPVLVGTALKNKGVQPLLDAVLDYLPNPGEVENLGFIEKEG 329
            :   .||.|.:...:::..|:....|||.|::|||..|||::||::||||:|.|     |.||..
pombe   262 EDSLAFTNDRLFKIIKQKTISGNVVPVLCGSSLKNIAVQPIMDAIIDYLPSPVE-----FYEKNA 321

  Fly   330 Q---DPEKVVLNPARDGKDPFVGLAFKL--EAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRI 389
            .   ..:|::   :.| |.|.:...||:  .|.| |.|||:|..:|.|.:|..:||.||.|..|.
pombe   322 SKETSSDKII---SLD-KRPLLAKIFKVIHHASR-GILTYVRVNEGTLSRGMMMFNPRTKKSERA 381

  Fly   390 ARLVRLHSNQMEDVNEVYAGDIFALFGV-DCASGDTFTT--NPKN-------NLSMESIFVPEPV 444
            .||..:.::|.::|:.:.||:|..:.|: ...:||....  |.||       |.|:  |.:||||
pombe   382 IRLYNVFADQTQEVDCISAGNIGVISGIKQFHTGDIIINKENSKNFHEYLSGNQSV--ISIPEPV 444

  Fly   445 VSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYGCP 509
            ...:|:|.:.||.....:|:|...:|||:|.:..|.:..:.|:.|||.:||::..:|:..|:|..
pombe   445 CIASIEPYSLKDEPALLEALANMNREDPSFRYTQDLENGQLLIQGMGIMHLQVSYERLVSEFGAR 509

  Fly   510 VTLGKPKVAFRETLVGPC-------------------------EFDYLHKKQ-SGGSGQYARIIG 548
            .:|||.:|.:||||:...                         |.|...||. |.|..|..|..|
pombe   510 ASLGKVQVGYRETLIDVSFNSVTLSTENKENLIINVYLIPISDEGDETLKKYFSEGEIQKVRSKG 574

  Fly   549 VMEPL------PPNQNTLLEFVD-ETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIR---- 602
            ..:.:      |.|..||.:.:. :.:..|:....|.|:        ..|.|.|..|:.::
pombe   575 QEDGVLFYGWKPENSCTLPDHLSFQRIQENIYFGIVAGL--------SHGPLHGFPLTNLQSFCT 631

  Fly   603 ---FRLQDGGHHIVDSSELAFMLAAHGAIKEVFQNG--SWQILEPIMLVEVTAPEEFQGAVMGHL 662
               |...|....::..   |.|.|...|:..:::..  |::||||.|.|.:|.|||:.|.|...|
pombe   632 ISSFLSNDFPLSLLTQ---ASMKATKNAVFSLYKRSPKSFRILEPYMDVTITTPEEYVGIVSKDL 693

  Fly   663 -------------------SKRHGIITGTEGTEGWF------------------------TVYAE 684
                               ||...|..|..| |.:.                        .:.|:
pombe   694 VGKRGATIKEITEIGKNAASKDSQIAIGILG-ERYLPADEPSSVKANNASSLLQSSSVIKCIRAQ 757

  Fly   685 VPLNDMFGYAGELRSSTQGKGEFTMEY 711
            |||..:..|...:.|.|:|..:|.|.:
pombe   758 VPLEQILDYNSVISSLTKGNAKFLMSH 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	115/298 (39%)
		PRK12740	48..727	CDD:237186	243/791 (31%)
		mtEFG1_II_like	347..427	CDD:293908	28/82 (34%)
		EFG_III	441..516	CDD:293919	27/74 (36%)
		EFG_mtEFG1_IV	519..636	CDD:238715	30/158 (19%)
		mtEFG1_C	641..718	CDD:239764	27/114 (24%)
SPBC660.10	NP_595089.1	FusA	24..810	CDD:223556	249/801 (31%)
		EF-G	30..313	CDD:206673	115/298 (39%)
		mtEFG2_II_like	338..420	CDD:293909	28/82 (34%)
		EFG_III	441..516	CDD:293919	27/74 (36%)
		EFG_C	669..783	CDD:279069	28/114 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810