DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and SPBC1306.01c

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_595472.2	Gene:	SPBC1306.01c / 2539776	PomBaseID:	SPBC1306.01c	Length:	770	Species:	Schizosaccharomyces pombe

Alignment Length:	765	Identity:	387/765 - (50%)
Similarity:	525/765 - (68%)	Gaps:	50/765 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TLRLRALKSLGKAGYSSHAKF--------------------SEHKPIERIRNIGISAHIDSGKTT 57
            |.||..|.:|...||:|.|..                    ::.|.:::||||||||||||||||
pombe    10 TSRLPRLSTLVVRGYASVANTGIEASNTSENNLNIQEQLNDNDKKRLKQIRNIGISAHIDSGKTT 74

  Fly    58 LTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSAATYTLWKDT------------ 110
            .|||:|:|||||.::|||||||||||.||.|||||::|||||||||:..|:.|
pombe    75 FTERVLYYTGRIKDIHEVRGKDNVGAKMDFMELEREKGITIQSAATHCTWERTVDQIEANEKQKT 139

  Fly   111 ------NINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCLAFI 169
                  ||||||||||:|||:|||||||||||||||||||.||||||:||:|||:|||||.::|:
pombe   140 DFEKSYNINIIDTPGHIDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYNVPRISFV 204

  Fly   170 NKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIYFEGEHGMDIRL-DE 233
            ||:||:|::|::|:.|:.:|:...||.:|:|||.|...:|:|||::.:|||..|..|..|.: .:
pombe   205 NKMDRMGADPWKVIQQINTKLKIPAAAVQIPIGQEDKLEGVVDLIQMRAIYNRGSKGEKIEISQQ 269

  Fly   234 IPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTALK 298
            :|:::...:.|:|..|||.|::.||.:.::::.|:..|.:.:..|:|||.:.|.|||||:|:||.
pombe   270 VPENLIELAKEKRSALIEKLADLDEEIADIYVMEEDPTPEQLMGAIRRTTLARKFTPVLMGSALS 334

  Fly   299 NKGVQPLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFKLEAGRFGQLT 363
            |.|||.:||||.||||||.||||:.....:.:.|  |.|.|:  .:.|.|.||||||.|||||||
pombe   335 NVGVQSVLDAVCDYLPNPSEVENIALNAADSEKP--VSLVPS--SEKPLVALAFKLEEGRFGQLT 395

  Fly   364 YLRCYQGVLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVNEVYAGDIFALFGVDCASGDTFTTN 428
            |||.|||.|::|:.|:|..:.||::::||||:|||.||::.:|.||.|.||||::||||||| |:
pombe   396 YLRIYQGTLKRGNYIYNVNSTKKIKVSRLVRMHSNDMEEIEKVEAGGICALFGIECASGDTF-TD 459

  Fly   429 PKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGEL 493
            ...:.:|.|:||||||:|:::|| .:||..:||||:.||.:|||||....||:.|||::||||||
pombe   460 GSVSYTMTSMFVPEPVISLSLKP-KSKDTTSFSKALNRFQREDPTFRVQLDNESKETIISGMGEL 523

  Fly   494 HLEIYAQRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGSGQYARIIGVMEPL----P 554
            |||:|.:||.|||......|||:|||||||.....|.|||||||||:||||::.|.:|.:    .
pombe   524 HLEVYVERMRREYKVDCETGKPRVAFRETLSKKVPFSYLHKKQSGGAGQYAKVEGYIEYMDGVED 588

  Fly   555 PNQNTL-LEFVDETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRFRLQDGGHHIVDSSEL 618
            .:.|.: .||:::..|..||.|::|..||.:.|..:||.|.||.:...||.|:||.:|.||||||
pombe   589 ESGNVVDCEFINKVTGGTVPTQYIPACEKAFYEALKKGFLIGHPIKNCRFVLEDGAYHPVDSSEL 653

  Fly   619 AFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTEGTEGWFTVYA 683
            ||.||...|.:..|...:..:|||||.|.:|||.|.||.|:|:|.||...|..::..|..||:.|
pombe   654 AFRLATISAFRTAFLQANPMVLEPIMNVSITAPVEHQGGVIGNLDKRKATIVDSDTDEDEFTLQA 718

  Fly   684 EVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPDVQDQIVRQYQESQ 733
            |||||.||.|:.::|:.|:|||||:||:.:|.|....||.::|..|.:.|
pombe   719 EVPLNSMFSYSSDIRALTKGKGEFSMEFLKYLPAPKYVQKELVDAYNKQQ 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	163/290 (56%)
		PRK12740	48..727	CDD:237186	368/702 (52%)
		mtEFG1_II_like	347..427	CDD:293908	50/79 (63%)
		EFG_III	441..516	CDD:293919	42/74 (57%)
		EFG_mtEFG1_IV	519..636	CDD:238715	55/121 (45%)
		mtEFG1_C	641..718	CDD:239764	40/76 (53%)
SPBC1306.01c	NP_595472.2	FusA	56..770	CDD:223556	377/719 (52%)
		EF-G	61..352	CDD:206673	163/290 (56%)
		mtEFG1_II_like	379..459	CDD:293908	50/80 (63%)
		EFG_III	472..546	CDD:293919	42/74 (57%)
		EFG_mtEFG1_IV	549..671	CDD:238715	55/121 (45%)
		mtEFG1_C	676..753	CDD:239764	40/76 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	330	1.000	Domainoid score	I210
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6449
Inparanoid	1	1.050	737	1.000	Inparanoid score	I87
OMA	1	1.010	-	-		QHG62898
OrthoFinder	1	1.000	-	-		FOG0003241
OrthoInspector	1	1.000	-	-		oto100792
orthoMCL	1	0.900	-	-		OOG6_100770
Panther	1	1.100	-	-	LDO	PTHR43636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R368
SonicParanoid	1	1.000	-	-		X2192
TreeFam	1	0.960	-	-
	14	13.860