DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and Y119D3B.14

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_497345.2	Gene:	Y119D3B.14 / 191043	WormBaseID:	WBGene00022491	Length:	731	Species:	Caenorhabditis elegans

Alignment Length:	772	Identity:	227/772 - (29%)
Similarity:	369/772 - (47%)	Gaps:	106/772 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRALKSLGKAGYSSHAKFSEHKPI-ERIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKD 79
            ||.|..|.:..||:    ....|. .::||||:.||:|:||||:|||:|:..|.|    .|.|..
Worm     2 LRLLLLLSRRCYST----PPPPPAPSKLRNIGVIAHVDAGKTTVTERLLYLAGAI----HVAGHV 58

  Fly    80 NVGATM-DSMELERQRGITIQSAATYTLWKDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCA 143
            :.|.|: |.:::||:||||:||||....||...||:|||||||||.|||||.:|||||.|:|:..
Worm    59 DKGNTVTDFLDIERERGITVQSAAVNLDWKGHRINLIDTPGHVDFRVEVERCVRVLDGIVVVIDG 123

  Fly   144 VGGVQSQTLTVNRQMKRYNVPCLAFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNC- 207
            ..|||.|||||.||..::.:|...||||:|:|.:|....:..:..|:...|..:.:|:......
Worm   124 SAGVQPQTLTVWRQSSKFKLPAHFFINKMDKLAANFENSVDSVEQKLGVRAVKLVVPLPENRGFN 188

  Fly   208 KGIVDLVREKAIYFEGEHGMDIRLDEIPQDMRVESL--ERRQELIEHLSNADETLGELFLEEKPF 270
            :|.:|::..|.:     .|........|::.....|  |.:.||...|:::.......||:|...
Worm   189 RGFLDILHSKML-----PGNSKNWQNPPKNSPEAELLAEHKSELCFTLADSHADFQSKFLDEFDG 248

  Fly   271 TED-----DIKAALRR-TCINRTFTPVLVGTALKN-KGVQPLLDAVLDYLPNPGEVENLGFIEKE 328
            ..:     ::|:.||. ||.::..| :..|:|:|| ..|:|:||||:|:.|.| |:.|..|.:..
Worm   249 NSEKIDVIEMKSVLRELTCASKIAT-ISCGSAVKNVHCVKPVLDAVVDFFPAP-EMRNREFRDVF 311

  Fly   329 GQDPEKVVLNPARDGKDPFVGLAFKL-EAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRIARL 392
            |:|               ..||.||: ...|.|||:|:|.|.|.|.....|||..........:|
Worm   312 GED---------------LSGLVFKITHDKRRGQLSYMRIYTGSLHNNSTIFNTSQMTSEGPLKL 361

  Fly   393 VRLHSNQMEDVNEVYAGDIFALFGVD-CASGDTFTT--------------------NPK--NNLS 434
            ...:::::..|.:|.||:|..:.|:. ..:|||...                    :||  |::.
Worm   362 FTPYADELRLVEQVSAGNITVVAGLQTTVTGDTVVASSASAEKACQKLAGSESSLLSPKDGNSVV 426

  Fly   435 MESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGELHLEIYA 499
            ...|..|:.|....|:|.:.:..:.|:||:...|:|||:....||.|..:|:|...||||||...
Worm   427 FSGIESPDAVFFCCIEPPSNRQLNQFNKALEELTREDPSMKIRFDRDTGQTIVETQGELHLEAIK 491

  Fly   500 QRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGS----GQYARIIGVMEPLPPNQNTL 560
            .|::|.|...|.:||.:||:||.|..  |..|..|.:.|.|    .::.::...:||      |.
Worm   492 DRLKRNYKLDVFIGKLQVAYREMLTE--ELSYTAKVEDGLSEKKRPEFVQLTMRLEP------TQ 548

  Fly   561 LEFVDETVGTNVPKQFVP-------GVEKGYREMAEKGMLSGHKLSGIRFRLQDGGHHIVDSSEL 618
            .....:.:...:|:...|       .|.:|.....:.|.|:.:.:..:|..|.:   .||...::
Worm   549 AHIPFKKIELELPQTARPVRLDWQKAVNEGCSNALQNGPLASYPVHAVRVVLTE---CIVSGGKI 610

  Fly   619 --AFMLA-AHGAIKEVFQNGSWQILEPIMLVEV-------TAPEEFQGAVMGHLSKRHGIITGTE 673
              |.:.| |...:.|...:|...:.||:|.|::       |.|      ::..|.:|......::
Worm   611 NPALLSACAQKCVSEALSSGEMVLTEPVMEVQIEIRNDDPTQP------ILNELLRRRAHFEHSD 669

  Fly   674 GTEGW--FTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPDVQDQIVRQ 728
            .||..  ..:.|.:||::....:..:|:.|.|.|:.::::..|.......:.:|:::
Worm   670 ATESTEIRRICAILPLSETENLSKTVRTLTSGFGDISVQFRGYQQVTEHEKMEILKK 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	108/282 (38%)
		PRK12740	48..727	CDD:237186	216/736 (29%)
		mtEFG1_II_like	347..427	CDD:293908	26/81 (32%)
		EFG_III	441..516	CDD:293919	28/74 (38%)
		EFG_mtEFG1_IV	519..636	CDD:238715	25/130 (19%)
		mtEFG1_C	641..718	CDD:239764	18/85 (21%)
Y119D3B.14	NP_497345.2	FusA	23..727	CDD:223556	220/747 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920