DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and eftu-2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_498308.1	Gene:	eftu-2 / 175851	WormBaseID:	WBGene00001166	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	866	Identity:	191/866 - (22%)
Similarity:	334/866 - (38%)	Gaps:	218/866 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRNIGISAHIDSGKTTLTERIL------FYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQS 100
            :||:.|:.|:..||||..:.::      ||          |.:|......|.:.:|:|||.:|:|
Worm   132 MRNVAIAGHLHHGKTTFLDCLMEQTHPEFY----------RAEDADARFTDILFIEKQRGCSIKS 186

  Fly   101 AATYTLWKDTN-----INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKR 160
            .....:.:|:.     :|||||||||:|:.|:..:.|:.||.|:::.|..||...|....|...:
Worm   187 QPVSIVAQDSRSKSYLLNIIDTPGHVNFSDEMTASYRLADGVVVMVDAHEGVMMNTERAIRHAIQ 251

  Fly   161 YNVPCLAFINKLDRL-------GSNPYRVLSQMRSKMNH-NAAFIQLPIGVESNCKGIV------ 211
            ..:.....|:|:|||       .::.|..|..:..::|: .:.|.:..:.|.|...|.|
Worm   252 ERLAVTLCISKIDRLLLELKLPPADAYFKLRLIIDQVNNILSTFAEEDVPVLSPLNGNVIFSSGR 316

  Fly   212 -----DLVREKAIYFEGEHGMDIRLDEIPQ----DMRVESLERRQELIEHLSNADETLGELFLEE 267
                 .|:....||.: :||......|..:    |:..|...|:........:|..|..:..||.
Worm   317 YNVCFSLLSFSNIYAK-QHGDSFNSKEFARRLWGDIYFEKKTRKFVKKSPSHDAPRTFVQFILEP 380

  Fly   268 --KPFTE--DDIKAALRRTCINRTFTPVLVGTALKNK----GVQPLL---------------DAV 309
              |.|::  .|:.     ||:......  :|..|..:    .|:||:               |.|
Worm   381 MYKIFSQVVGDVD-----TCLPDVMAE--LGIRLSKEEQKMNVRPLIALICKRFFGDFSAFVDLV 438

  Fly   310 LDYLPNPGEVENLGFIEKEGQDPEKVVLNPAR----------DGKDPFVGLAFKL----EAGRFG 360
            :..:.:|        :|......|:..|.||.          :.:.|.:....|.    :|.:|.
Worm   439 VQNIKSP--------LENAKTKIEQTYLGPADSQLAQEMQKCNAEGPLMVHTTKNYPVDDATQFH 495

  Fly   361 QLTYLRCYQGVLRK-------GDN--IFNARTNKKVRIARL-VRLHSNQMEDVNEVYAGDIFALF 415
              .:.|...|.|..       |:|  |.:....:::.:.|| ||:.|.|:| |:.|.||....:.
Worm   496 --VFGRVMSGTLEANTDVRVLGENYSIQDEEDCRRMTVGRLFVRVASYQIE-VSRVPAGCWVLIE 557

  Fly   416 GVDCASGDTFTTNPKNNLSMESIFVPEPV-------VSMAIKPNNTKDRDNFSKAIARFTKEDPT 473
            |:|.....|.|.....  ..|.:::..|:       |.:|::|.|..:.......:.:..|..|.
Worm   558 GIDQPIVKTATIAELG--YEEDVYIFRPLKFNTRSCVKLAVEPINPSELPKMLDGLRKVNKSYPL 620

  Fly   474 FHFFFDNDVKETLVSGMGELHLEIYAQRMEREYG-CPVTLGKPKVAFRETLVG----PCEFDYLH 533
            .....:...:..|: |.||.:::.....|.:.:. ..:.:..|.|.|.||::.    .|..:..:
Worm   621 LTTRVEESGEHVLL-GTGEFYMDCVMHDMRKVFSEIDIKVADPVVTFNETVIETSTLKCFAETPN 684

  Fly   534 KK-----------------------QSGGS----GQY-----------ARIIGVMEPLPPNQNTL 560
            ||                       |.|.:    |::           ||.|....|.....|.|
Worm   685 KKNKITMMAEPLEKQLDEDIENEVVQIGWNRRRLGEFFQTKYNWDLLAARSIWAFGPDTTGPNIL 749

  Fly   561 LEFVDETVGTNVPKQFVPGVE----KGYREMAEKGMLSGHKLSGIRFRLQD----------GGHH 611
            |   |:|:.:.|.|..:..|.    :|::....:|.|....:..::|:|.|          ||..
Worm   750 L---DDTLPSEVDKHLLSTVRESLVQGFQWATREGPLCEEPIRQVKFKLLDAAIATEPLYRGGGQ 811

  Fly   612 IVDSSE----LAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGT 672
            ::.::.    .||::|..            :::||...|||.||.:...||...|:||.|.:|..
Worm   812 MIPTARRCAYSAFLMATP------------RLMEPYYTVEVVAPADCVAAVYTVLAKRRGHVTTD 864

  Fly   673 EGTEG--WFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLP-------------DVQ 722
            ....|  .:|:.|.:|:.|.||:..:||..|||:. |.|....:...:|             |||
Worm   865 APMPGSPMYTISAYIPVMDSFGFETDLRIHTQGQA-FCMSAFHHWQLVPGDPLDKSIVIKTLDVQ 928

  Fly   723 --DQIVRQY----QESQGLAQ 737
              ..:.|::    :..:||::
Worm   929 PTPHLAREFMIKTRRRKGLSE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	77/328 (23%)
		PRK12740	48..727	CDD:237186	185/844 (22%)
		mtEFG1_II_like	347..427	CDD:293908	23/93 (25%)
		EFG_III	441..516	CDD:293919	12/82 (15%)
		EFG_mtEFG1_IV	519..636	CDD:238715	32/176 (18%)
		mtEFG1_C	641..718	CDD:239764	28/78 (36%)
eftu-2	NP_498308.1	EFTUD2	4..113	CDD:374287
eftu-2	NP_498308.1	FusA	125..958	CDD:357662	191/866 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810