DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mEFG1 and gfm-1

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_496787.1	Gene:	gfm-1 / 174956	WormBaseID:	WBGene00009246	Length:	750	Species:	Caenorhabditis elegans

Alignment Length:	709	Identity:	421/709 - (59%)
Similarity:	537/709 - (75%)	Gaps:	1/709 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KPIERIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSA 101
            :||||||||||||||||||||:|||||:|.|||..||||||||:||||||.|:||||||||||||
Worm    39 RPIERIRNIGISAHIDSGKTTVTERILYYAGRIDSMHEVRGKDDVGATMDFMDLERQRGITIQSA 103

  Fly   102 ATYTLWKDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCL 166
            |||..|..|||||||||||||||||||||||||||||||||.||||||||.|||||:.|||||.:
Worm   104 ATYVDWHGTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCGVGGVQSQTFTVNRQLARYNVPFI 168

  Fly   167 AFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIYFEGEHGMDIRL 231
            .|:||:||.|:.|.:.|..:|:|:|||||.|.||||.:||..||||||...|:|:|||.|:.:|.
Worm   169 CFVNKMDRNGATPLKALDGLRNKLNHNAALIHLPIGKDSNFNGIVDLVEGHALYYEGEGGLIVRK 233

  Fly   232 DEIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTA 296
            ||||:|:|||:.:||||||||::|.||||||:||.::......|..|:|||.:.|.|.|||.|:|
Worm   234 DEIPKDLRVEAEDRRQELIEHIANVDETLGEMFLNDQTPNVQQIHEAIRRTVVKRAFVPVLSGSA 298

  Fly   297 LKNKGVQPLLDAVLDYLPNPGEVENLGFIEKEGQDPEK-VVLNPARDGKDPFVGLAFKLEAGRFG 360
            |||||||.::::|:.|||:|.||.|...::.|....|| ::|:|.|:...||||||||||||::|
Worm   299 LKNKGVQTMINSVVKYLPDPSEVVNRATVKTETTGDEKGIILSPKRNNDKPFVGLAFKLEAGKYG 363

  Fly   361 QLTYLRCYQGVLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVNEVYAGDIFALFGVDCASGDTF 425
            ||||.|.|||.|.|||.::.:|..:|||:.||||:|:..||::...|||||.|.||:||.||:||
Worm   364 QLTYFRVYQGQLSKGDTVYASRDGRKVRVQRLVRMHAADMEEITTAYAGDICATFGLDCHSGETF 428

  Fly   426 TTNPKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGM 490
            :|:.......||:.:||||:||||||.|.||.|||.||:.|||||||||...::.:.|||:||||
Worm   429 STDQNLAPHCESMHIPEPVISMAIKPVNRKDADNFIKALTRFTKEDPTFRREYNQEAKETIVSGM 493

  Fly   491 GELHLEIYAQRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGSGQYARIIGVMEPLPP 555
            ||||||||||||:.||.|||.||||.||:||.|..|.:|.:.||||:||.||:..|.||::|||.
Worm   494 GELHLEIYAQRMKSEYNCPVELGKPTVAYRECLGSPYKFHFRHKKQTGGQGQFGEIEGVIDPLPS 558

  Fly   556 NQNTLLEFVDETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRFRLQDGGHHIVDSSELAF 620
            ::||::||.|||.|.|:||...|.::||...:..:|.|...:::||..|:|||..|.|||:|:|.
Worm   559 DRNTVVEFSDETFGNNIPKNLFPALKKGLDAIVAEGPLIKSRIAGIHVRIQDGSTHAVDSTEIAM 623

  Fly   621 MLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTEGTEGWFTVYAEV 685
            :......::|.|:..:|.:|||||.||.|.|.||||.|:..|::|:.:||.|:.|||:.||..|.
Worm   624 INTMQNMMRESFEKANWLLLEPIMKVEATVPTEFQGNVVTSLTQRNALITTTDSTEGYATVICEA 688

  Fly   686 PLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPDVQDQIVRQYQESQGLAQPDKKKKK 744
            ||:|||||..||||.|:|||||:||||||:|...:.||::..::::..|:|.|::|.||
Worm   689 PLSDMFGYTSELRSLTEGKGEFSMEYSRYAPTTLEAQDRVQAEWRQLHGIADPNEKGKK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	188/271 (69%)
		PRK12740	48..727	CDD:237186	405/679 (60%)
		mtEFG1_II_like	347..427	CDD:293908	49/79 (62%)
		EFG_III	441..516	CDD:293919	54/74 (73%)
		EFG_mtEFG1_IV	519..636	CDD:238715	49/116 (42%)
		mtEFG1_C	641..718	CDD:239764	48/76 (63%)
gfm-1	NP_496787.1	EF-G	46..318	CDD:206673	188/271 (69%)
		PRK12740	50..730	CDD:237186	405/679 (60%)
		mtEFG1_II_like	350..430	CDD:293908	49/79 (62%)
		EFG_III	444..518	CDD:293919	53/73 (73%)
		EFG_mtEFG1_IV	522..639	CDD:238715	49/116 (42%)
		mtEFG1_C	644..721	CDD:239764	48/76 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160490
Domainoid	1	1.000	388	1.000	Domainoid score	I416
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6449
Inparanoid	1	1.050	861	1.000	Inparanoid score	I213
Isobase	1	0.950	-	0	Normalized mean entropy	S370
OMA	1	1.010	-	-		QHG62898
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	1	1.000	-	-		FOG0003241
OrthoInspector	1	1.000	-	-		oto19939
orthoMCL	1	0.900	-	-		OOG6_100770
Panther	1	1.100	-	-	LDO	PTHR43636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R368
SonicParanoid	1	1.000	-	-		X2192
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790