DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and Eef2

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_031933.1	Gene:	Eef2 / 13629	MGIID:	95288	Length:	858	Species:	Mus musculus

Alignment Length:	858	Identity:	209/858 - (24%)
Similarity:	345/858 - (40%)	Gaps:	191/858 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGAT--MDSMELERQRGITIQSAATY 104
            |||:.:.||:|.||:|||:.::...|.||..       ..|.|  .|:.:.|::|.|||:|.|..
Mouse    19 IRNMSVIAHVDHGKSTLTDSLVCKAGIIASA-------RAGETRFTDTRKDEQERCITIKSTAIS 76

  Fly   105 TLWK----DTN------------INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLT 153
            ..::    |.|            ||:||:||||||:.||..||||.|||::|:..|.||..||.|
Mouse    77 LFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTET 141

  Fly   154 VNRQMKRYNVPCLAFINKLDR----LGSNPYRVLSQMRSKMNHNAAFIQLPIGV-ESNCKG--IV 211
            |.||.....:..:..:||:||    |...| ..|.|...::..|...|....|. ||...|  ::
Mouse   142 VLRQAIAERIKPVLMMNKMDRALLELQLEP-EELYQTFQRIVENVNVIISTYGEGESGPMGNIMI 205

  Fly   212 DLVREKAIYFEGEHGMDIRLDEIPQ----------DMRVESLERRQELIEHLSNADETLGELFLE 266
            |.|.....:..|.||....|.:..:          :.::.:.||.:::.:.:.   :..|:.:.:
Mouse   206 DPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLSAAERAKKVEDMMK---KLWGDRYFD 267

  Fly   267 ------EKPFTEDDIKAALRRTC------INRTFTPVL-----------------VGTALKNKGV 302
                  .|.....|.|...|..|      |.:.|..::                 :.:..|:|..
Mouse   268 PANGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDIKLDSEDKDKEG 332

  Fly   303 QPLLDAVLD---------------YLPNP--GEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGL 350
            :|||.||:.               :||:|  .:......:.:...|.|..:...:.|.|.|.:..
Mouse   333 KPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMY 397

  Fly   351 AFKL----EAGRFGQLTYLRCYQGVLRKGDNIF----NARTNKK-----VRIARLVRLHSNQMED 402
            ..|:    :.|||  ..:.|.:.||:..|..:.    |....||     ..|.|.:.:....:|.
Mouse   398 ISKMVPTSDKGRF--YAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEP 460

  Fly   403 VNEVYAGDIFALFGVD---CASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAI 464
            :.:|..|:|..|.|||   ..:|...|....:|:.:.. |...|||.:|::..|..|.....:.:
Mouse   461 IEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMK-FSVSPVVRVAVEAKNPADLPKLVEGL 524

  Fly   465 ARFTKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYGC-PVTLGKPKVAFRETLVGPCE 528
            .|..|.||......: :..|.:::|.|||||||..:.:|.::.| |:....|.|::|||:.....
Mouse   525 KRLAKSDPMVQCIIE-ESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESN 588

  Fly   529 FDYLHKKQSGGSGQYARI---------------IGVMEPLPPNQNTLLE--------------FV 564
            ...|.|..:..:..|.:.               :...:.|......|.|              |.
Mouse   589 VLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAEARKIWCFG 653

  Fly   565 DETVGTNVPKQFVPGVE----------KGYREMAEKGMLSGHKLSGIRFRLQD----------GG 609
            .:..|.|:......||:          .|::...::|.|....:.|:||.:.|          ||
Mouse   654 PDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGG 718

  Fly   610 HHIVDSSE---LAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITG 671
            ..|:.::.   .|.:|.|..           :::|||.|||:..||:..|.:.|.|:::.|.:..
Mouse   719 GQIIPTARRCLYASVLTAQP-----------RLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFE 772

  Fly   672 TEGTEG--WFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPD-----VQDQIVRQY 729
            .....|  .|.|.|.:|:|:.||:..:|||:|.|:.        :..|:.|     ..|......
Mouse   773 ESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQA--------FPQCVFDHWQILPGDPFDNSS 829

  Fly   730 QESQGLAQPDKKK 742
            :.||.:|:..|:|
Mouse   830 RPSQVVAETRKRK 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	92/350 (26%)
		PRK12740	48..727	CDD:237186	201/835 (24%)
		mtEFG1_II_like	347..427	CDD:293908	22/95 (23%)
		EFG_III	441..516	CDD:293919	22/75 (29%)
		EFG_mtEFG1_IV	519..636	CDD:238715	27/168 (16%)
		mtEFG1_C	641..718	CDD:239764	25/78 (32%)
Eef2	NP_031933.1	PTZ00416	1..858	CDD:240409	209/858 (24%)
		EF2	20..233	CDD:206672	74/220 (34%)
		EF2_snRNP_like_II	394..488	CDD:293901	22/95 (23%)
		EF2_snRNP_III	503..574	CDD:293918	22/71 (31%)
		aeEF2_snRNP_like_IV	574..746	CDD:238839	32/182 (18%)
		eEF2_snRNP_like_C	742..821	CDD:239763	27/86 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810