DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFG1 and gfm1

DIOPT Version :9

Sequence 1:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_002933285.1	Gene:	gfm1 / 100494046	XenbaseID:	XB-GENE-983072	Length:	748	Species:	Xenopus tropicalis

Alignment Length:	748	Identity:	485/748 - (64%)
Similarity:	596/748 - (79%)	Gaps:	18/748 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRALKSLGKAGYSS--HAKFSEHKPI---------------ERIRNIGISAHIDSGKTTLTERIL 63
            :|.|:...|.|..:  ::..:.:||:               ||||||||||||||||||||||:|
Frog     1 MRLLREASKLGSQALRYSGITRNKPLPLTFCRYCSSGIVPNERIRNIGISAHIDSGKTTLTERVL 65

  Fly    64 FYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSAATYTLWKDTNINIIDTPGHVDFTVEVE 128
            :||||||:||||:|||.|||.|||||||||||||||||||||:||||||||||||||||||:|||
Frog    66 YYTGRIAQMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDTNINIIDTPGHVDFTIEVE 130

  Fly   129 RALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCLAFINKLDRLGSNPYRVLSQMRSKMNHN 193
            ||||||||||||||||||||.||:||||||||||||.|.||||||||||||.|.:.|:|||:|||
Frog   131 RALRVLDGAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRLGSNPNRAVQQLRSKLNHN 195

  Fly   194 AAFIQLPIGVESNCKGIVDLVREKAIYFEGEHGMDIRLDEIPQDMRVESLERRQELIEHLSNADE 258
            |||:|:|||:||..|||:|||.|:|:||:||.|..:|.::||.:.|.|:::|||||||.::|:||
Frog   196 AAFVQIPIGIESKFKGIIDLVEERAMYFDGEFGQTMRYEDIPAEFRAEAMDRRQELIESVANSDE 260

  Fly   259 TLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTALKNKGVQPLLDAVLDYLPNPGEVENLG 323
            .|||:|||||..|..|:|.|:||..:.|.|||||||:|||||||||||:|||:|||||.||:|..
Frog   261 ILGEMFLEEKIPTVSDLKLAIRRATLKRLFTPVLVGSALKNKGVQPLLEAVLEYLPNPSEVQNFA 325

  Fly   324 FIEKE-GQDPEKVVLNPARDGKDPFVGLAFKLEAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKV 387
            .:..| .::..|:::|..||...|||||||||||||||||||:|.|||:|:|.|.|||.||.|||
Frog   326 ILNHENSEEATKILMNSVRDSSQPFVGLAFKLEAGRFGQLTYVRVYQGMLQKSDYIFNTRTGKKV 390

  Fly   388 RIARLVRLHSNQMEDVNEVYAGDIFALFGVDCASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPN 452
            |:.||||||::.||||.|.|||||.||||:|||||||||:...:|||||||.||:||:|:|:||.
Frog   391 RVQRLVRLHADMMEDVEEAYAGDICALFGIDCASGDTFTSKSNDNLSMESIHVPDPVISVAMKPT 455

  Fly   453 NTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYGCPVTLGKPKV 517
            |..|.|.|||.|:|||:|||||...::.:.|||::|||||||||||||||||||.||..:|||||
Frog   456 NKNDLDKFSKGISRFTREDPTFRVHYEVESKETIISGMGELHLEIYAQRMEREYACPCVMGKPKV 520

  Fly   518 AFRETLVGPCEFDYLHKKQSGGSGQYARIIGVMEPLPPNQNTLLEFVDETVGTNVPKQFVPGVEK 582
            |||||:.....||:.|||||||:|||.::||.:|||.....|.|||.|:||||||||||||.||:
Frog   521 AFRETISKTVPFDFTHKKQSGGAGQYGKVIGFLEPLEAENYTKLEFEDKTVGTNVPKQFVPAVER 585

  Fly   583 GYREMAEKGMLSGHKLSGIRFRLQDGGHHIVDSSELAFMLAAHGAIKEVFQNGSWQILEPIMLVE 647
            |:||..|||.|:|||:||:||.|:||.||:|||:|::|:.|..||:|:..:|.:..||||||.||
Frog   586 GFREACEKGPLTGHKISGLRFVLEDGAHHMVDSNEISFIRAGEGALKQAMENATVCILEPIMSVE 650

  Fly   648 VTAPEEFQGAVMGHLSKRHGIITGTEGTEGWFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYS 712
            |.||.||||.|:..:::|||:|.|.:|:||:||:||:||||||||||.||||.|:||||:|||||
Frog   651 VVAPSEFQGPVIAGINRRHGVIVGQDGSEGYFTLYADVPLNDMFGYASELRSCTEGKGEYTMEYS 715

  Fly   713 RYSPCLPDVQDQIVRQYQESQGLAQPDKKKKKN 745
            ||.|||...|::::.:|.|:.|.....|.|.|:
Frog   716 RYQPCLASTQEELINKYLEATGQLPAKKGKAKS 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	208/271 (77%)
		PRK12740	48..727	CDD:237186	465/679 (68%)
		mtEFG1_II_like	347..427	CDD:293908	62/79 (78%)
		EFG_III	441..516	CDD:293919	48/74 (65%)
		EFG_mtEFG1_IV	519..636	CDD:238715	69/116 (59%)
		mtEFG1_C	641..718	CDD:239764	53/76 (70%)
gfm1	XP_002933285.1	PRK12740	50..729	CDD:237186	465/678 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	435	1.000	Domainoid score	I568
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6449
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I300
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	1	1.000	-	-		FOG0003241
OrthoInspector	1	1.000	-	-		oto102913
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2192
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060