Protein Alignment SLC6A19 and CG43066

DIOPT Version :10

• Sequence 1: NP_001003841.1
• Gene: SLC6A19 / 340024
• HGNCID: 27960
• Length: 634
• Species: Homo sapiens
• Sequence 2: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 280/614 - (45%)
• Similarity: 409/614 - (66%)
• Gaps: 32/614 - (5%)

Human    32 RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRL 96
            |..|..|.|:.|:.:|:.|||||:||||||||.:|||||:|||:::|:||||||..:|..||||:
  Fly    55 RAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRM 119

Human    97 RRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTG 161
            |.|:||||::|||.|.|:|::|.:.:..|.||||.||:|:.:||||||:.|||||.|||  |.||
  Fly   120 RLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPL--NGTG 182

Human   162 Y-VDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYI 225
            : ::|||:||...|||||.||:.:.|:.:.|.::||::|||..:|::::...::||:::||.||.
  Fly   183 FELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYF 247

Human   226 TSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFS 290
            ||..||:|||||.|||:||:||..|::.::||.|.:|.:|..||||..|||:||.||||.||:|.
  Fly   248 TSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFG 312

Human   291 SYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNV 355
            |||:..|||.:|.::||:.|..|::|.::|:::::||:||...|.|.::|...|:.. .|...|.
  Fly   313 SYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKN-KLLGLND 376

Human   356 TQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLF 420
            ||    ..:|..:..:.....:|....|.:...|..|.|||||||||||:||.::|.:|.|:|||
  Fly   377 TQ----GYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLF 437

Human   421 FIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLL 485
            |.||..|||.|..|.:||::..|.|:.:| .:..|:.:||::||..|::||||...:|:|||.:.
  Fly   438 FTMLLSLGLGSQIGILEGMLCTLFDIDII-KRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMF 501

Human   486 DSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFF 550
            ||:||:|.|:::|..||.:|:::||.:||.:||..|.|::|..:||.|||.:.|::|:.|.:...
  Fly   502 DSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSV 566

Human   551 VVEVSQELTYSIW--DPGYEEFPKSQKISYPNWVYVVV--VIVAGVPSLTIPGYAIYKLIRN-HC 610
            |..|.:..||..|  |.|..|    || ||||||..:.  :|:|||  |.:|   |..|:|: .|
  Fly   567 VFMVIRNPTYGAWNADLGMIE----QK-SYPNWVMGIALSMILAGV--LPMP---IVFLMRSFQC 621

Human   611 QKP--GDHQGLV----STLSTASM--NGD 631
            .|.  ..|||.:    :|.||..|  |.|
  Fly   622 LKVDLDIHQGSIRRNETTASTKEMIDNDD 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:444915	270/585 (46%)
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	268/579 (46%)