DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4496 and Sry-delta

DIOPT Version :9

Sequence 1:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	92/428 - (21%)
Similarity:	141/428 - (32%)	Gaps:	124/428 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 VVAEIELSDSDHDEDSEVDEDVSLPSNAVSCVLNEQRQDGSQNPQELVIIVPSDQEDEQKTDN-- 218
            :|.|:|:..||.:.|::.:.|.....     ::.:|.:..::..:|.|     |:|:|:..|:
  Fly   107 LVEEVEIPQSDVETDADAEADALFVE-----LVKDQEESDTEIKREFV-----DEEEEEDDDDDD 161

  Fly   219 --------------VIKRKSSGSRRLVKRRPGANRRGRHMYECPDCGKKVQSNYNLRRHMMIHTG 269
                          :..:.|.|..|..|:|.        ..||..|||...|.|.|::|:
  Fly   162 EFICEDVDVGDSEALYGKSSDGEDRPTKKRV--------KQECTTCGKVYNSWYQLQKHI----- 213

  Fly   270 ERPFPCDLCERRFREFSDLKKHRRRHSHDPQFICMICHLGAPLEQDSTRCADCESKNLMVKPQPE 334
                                  ...||..|..||.||.:   :.:|
  Fly   214 ----------------------SEEHSKQPNHICPICGV---IRRD------------------- 234

  Fly   335 ELGEKTTEEHSDEMEGDDDEIEEAALENEKQPQVATQPSLMVTLIPPIQSPPEKVPSHTQPSRPP 399
               |:..|.|.:..||          :.|||.:..          |...|.|.....|.:.....
  Fly   235 ---EEYLELHMNLHEG----------KTEKQCRYC----------PKSFSRPVNTLRHMRMHWDK 276

  Fly   400 LPRSCSSANSSSSLSNDGNIAGKSMSRTRRSYP--CPLCHRPFGTRHNLKRHYMIHTGEKP-FSC 461
            ....|...  ....|.|..:....:.......|  |.:|:..|.:|.....|.:||...:| ..|
  Fly   277 KKYQCEKC--GLRFSQDNLLYNHRLRHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYC 339

  Fly   462 SKCRKPFRECSTLKKHMVTHVRDRWYKCL-RCPSKFRDYLEYSDHKNNHQDQLSSRKS-SIYESD 524
            |.|.|.|.|..|||.||.||..|..|... ..|:..:..:|     ..|.|...|..: ::..||
  Fly   340 SVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPADEQQVVE-----ELHVDVDESEAAVTVIMSD 399

  Fly   525 DDGDSSVEDCLECCECQQRFTELDAYTAHLK-KHDLEL 561
            :|.:|..     |..|...|........||: .||:.|
  Fly   400 NDENSGF-----CLICNTNFENKKELEHHLQFDHDVVL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523	9/21 (43%)
		C2H2 Zn finger	247..267	CDD:275368	8/19 (42%)
		zf-H2C2_2	259..282	CDD:290200	2/22 (9%)
		C2H2 Zn finger	275..295	CDD:275368	0/19 (0%)
		zf-C2H2	431..453	CDD:278523	6/23 (26%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		zf-H2C2_2	445..468	CDD:290200	8/23 (35%)
		C2H2 Zn finger	461..481	CDD:275368	11/19 (58%)
		C2H2 Zn finger	489..510	CDD:275368	2/21 (10%)
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	48/228 (21%)
		C2H2 Zn finger	225..245	CDD:275368	7/44 (16%)
		C2H2 Zn finger	253..273	CDD:275368	4/29 (14%)
		C2H2 Zn finger	281..301	CDD:275368	3/21 (14%)
		C2H2 Zn finger	310..327	CDD:275370	4/16 (25%)
		zf-C2H2	337..359	CDD:278523	11/21 (52%)
		C2H2 Zn finger	339..359	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100