DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4496 and az2

DIOPT Version :9

Sequence 1:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	109/600 - (18%)
Similarity:	190/600 - (31%)	Gaps:	227/600 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IPP--------DPVRYEYQEPEE---NFISIDDVKIKSFLWQIGQQQR--------------EKE 80
            :||        .||..|.:|.:|   :.:::|        .::|.:..              .:.
  Fly    95 VPPSSENDESTSPVEEEEEEDDEVDSSSMTVD--------CELGTRNSTHFAPLTKFNPTFYRRS 151

  Fly    81 LEIKRIMEQEKR-----EKREKERREAEKRRD--QEVIELDEEEAQSPRGLIISAAR------SL 132
            ..|.:.:|..|:     :..::..|:.|||.:  :|::    |:.::...|.::|.:      ||
  Fly   152 PRITQFIELYKQQTCLWDPADESYRDKEKRANAYEELL----EQLKATVNLHLTAYKLKKCITSL 212

  Fly   133 AHWNSSIRR--VTPDIELIPRRVH---RVVAEI-ELSDSDHDEDSEVDEDVSL------------ 179
            ....:||.|  .|..:..:|...|   ..:||. .|.|:|.| |.:.|..:.|
  Fly   213 HAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSD-DVDGDGKIKLVFTEENQLTTQF 276

  Fly   180 ------------PSNAVSCVLNEQRQ------DGSQNPQELVIIVPSDQED-------------E 213
                        |::...|.||.::.      |...:...|.::...|..|             :
  Fly   277 IDLYSKFPQLYDPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDSIQSMRQWYSRRIK 341

  Fly   214 QKTDNVIKRKSSGSRRLVKR----RPGANRRGRHMYECPDCGKKVQSNYNL-----RRHMMIHTG 269
            ..||......|...::.::|    .|  .:..|...:|..|.....:::.|     |.|.|...|
  Fly   342 TLTDVQCVGLSLAEKQYIERCNSFMP--TKSFRQKLKCEVCEHSFSTDHALQAHQFRDHKMGDGG 404

  Fly   270 ERPFPCDLCERRFREFSDLKKHRRRHSHDPQFICMIC--------------------HLGAPLEQ 314
            .  |.|.|||..|.....|::|.:|...|..|:|.||                    |:..|...
  Fly   405 W--FRCTLCELNFDRKCHLQQHSQRVHMDKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVC 467

  Fly   315 DSTRCADCESKNLMVKPQPEELGEKTTEEHSDEMEGDDDEIEEAALENEKQPQVATQPSLMVTLI 379
            :.  |..|..:.:                                       |:.|.    ||.:
  Fly   468 EF--CGKCFKQKI---------------------------------------QMTTH----VTAV 487

  Fly   380 PPIQSPPEKVPSHTQPSRPPLPRSCSSANSSSSLSNDGNIAGKSMSRTRRSYPCPLCHRPFGTRH 444
                        ||:                                 .|::.|.:|.:.|.|:.
  Fly   488 ------------HTK---------------------------------IRAFKCDMCPKDFLTKR 507

  Fly   445 NLKRHYMIHTGEKPFSCSKCRKPFRECSTLKKHMVTHVRDRWYKCLRCPSKFRDYLEYSDHKNNH 509
            :||.|...|...:...|..|:|.|...:.|.||...| :::..:|..|.::|.:.:....|....
  Fly   508 DLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIH-KEKTLQCSLCTTRFSERVSLGVHMRRT 571

  Fly   510 QDQLSSRKSSIYESD 524
            ...|   |||:..||
  Fly   572 HKIL---KSSLSSSD 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523	6/26 (23%)
		C2H2 Zn finger	247..267	CDD:275368	6/24 (25%)
		zf-H2C2_2	259..282	CDD:290200	10/27 (37%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		zf-C2H2	431..453	CDD:278523	7/21 (33%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		zf-H2C2_2	445..468	CDD:290200	7/22 (32%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..510	CDD:275368	4/20 (20%)
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	18/88 (20%)
		GT1	276..>341	CDD:304916	8/64 (13%)
		C2H2 Zn finger	377..398	CDD:275368	4/20 (20%)
		C2H2 Zn finger	408..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	3/19 (16%)
		C2H2 Zn finger	467..488	CDD:275368	6/77 (8%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100