DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4496 and lst-5

DIOPT Version :9

Sequence 1:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_872063.2	Gene:	lst-5 / 353399	WormBaseID:	WBGene00016890	Length:	346	Species:	Caenorhabditis elegans

Alignment Length:	295	Identity:	56/295 - (18%)
Similarity:	99/295 - (33%)	Gaps:	108/295 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 CES----KNLMVKPQPEELGEKTTEEHSDEME-------GDDDEIEEAALENEKQPQVATQPSLM 375
            |||    |:.:.|.....:  .::.:|.|:::       .:::|.||.:||..:...|  .||
Worm    12 CESLEETKDYLSKRSDRTI--NSSLKHKDDLQFQEEFVVKEEEEEEELSLERGESSNV--HPS-- 70

  Fly   376 VTLIPPIQSPPEKVPSH----------TQPSRPPLPRSCSSANSSSSLSNDGNIAGKSMSRTR-- 428
                          .:|          :..:..|:|:                   :.|:|.:
Worm    71 --------------DAHGYLGMCDFEDSDDTMMPVPK-------------------REMTRQKFR 102

  Fly   429 ----RSYPCPLCHRPFGTRHNLKRHYM-IHTGEKPF-------SCSKCRKPFRECSTLKKHMVTH 481
                :.|.|..|.|.|..:|||:.|:: .|.|.|..       .|..|.|.:...|.|.:||:..
Worm   103 RFRHKEYQCDECDRMFTLKHNLQNHFVQYHMGCKTLHKACVSSKCDICGKIYSAVSVLAEHMLNE 167

  Fly   482 VRDRWYKCLRCPSKFRDYLEYSDHKNNHQDQLSSRKSSIYESDDDGDSSVEDC------------ 534
             .:|:...:.||.....:|..:..:.:.::.....|...|          ::|
Worm   168 -HNRYLDQIECPDCHEFFLTQTALQKHMKEHKREEKHCPY----------KECRGIKFRFNRELN 221

  Fly   535 -----------LECCECQQRFTELDAYTAHLKKHD 558
                       |.||.|...|.:|.|...|.|.|:
Worm   222 EHVRLQHKSKELSCCVCNMVFRQLSAKIKHEKTHE 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523
		C2H2 Zn finger	247..267	CDD:275368
		zf-H2C2_2	259..282	CDD:290200
		C2H2 Zn finger	275..295	CDD:275368
		zf-C2H2	431..453	CDD:278523	9/22 (41%)
		C2H2 Zn finger	433..453	CDD:275368	8/20 (40%)
		zf-H2C2_2	445..468	CDD:290200	9/30 (30%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..510	CDD:275368	3/20 (15%)
lst-5	NP_872063.2	C2H2 Zn finger	111..132	CDD:275368	8/20 (40%)
		C2H2 Zn finger	147..168	CDD:275368	7/21 (33%)
		C2H2 Zn finger	177..197	CDD:275368	3/19 (16%)
		C2H2 Zn finger	208..227	CDD:275368	1/18 (6%)
		C2H2 Zn finger	235..255	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5489
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950