DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4496 and CG12299

DIOPT Version :9

Sequence 1:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	670	Identity:	137/670 - (20%)
Similarity:	213/670 - (31%)	Gaps:	242/670 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LIP---PDPVRYEYQEPEENFISIDDVKIKSF------LWQIGQQQREKELEIKRIMEQEKREKR 95
            |:|   |:|.:.:.|:|:...::...:....|      |:|          .:..:...|....:
  Fly    25 LLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQ----------HMNTLHPHEPGNGQ 79

  Fly    96 EKERREAEKRRD-----QEVIELDEEEAQSPRGLIISAARSLAHWNSSIRRVTPDIELIPRRVHR 155
            :::....::..|     :.|.||.|:.:.|..|...|.:.|    :||
  Fly    80 QEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDS----SSS----------------- 123

  Fly   156 VVAEIELSDSDHDED-------SEVDEDVSLPSNAVSCVLNEQRQDGSQNPQELVIIVPSDQEDE 213
                   ||.|.|:|       |....:.|..|::|....|...|...::.|.|..:|.....:|
  Fly   124 -------SDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNE 181

  Fly   214 ---QKTDNVIKRKSSG------------------------------SRRLVKRR----------- 234
               |.||   .|:|:.                              |..:.:||
  Fly   182 FQLQMTD---PRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVM 243

  Fly   235 --------------------PGANRRGRHM--------YECPDCGKKVQSNYNLRRHMMIHTGER 271
                                |.|....:|:        ::|..|.|......:|..|:.||:||:
  Fly   244 DPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEK 308

  Fly   272 PFPCDLCERRFREFSDLKKHRRRHSHDPQFICMICHLG---------------APLEQDSTRCAD 321
            |:.|:||.:.|.:.|.|..|.|.||......|:.|..|               ||.|  :..|.:
  Fly   309 PYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTE--TFICPE 371

  Fly   322 CESKNLMVKPQPEELGEKTTEEHSDEMEGDDDEIEEAALENEKQPQVATQPSLMVTLIPPIQSPP 386
            ||.         |...|...:||
  Fly   372 CER---------EFKAEALLDEH------------------------------------------ 385

  Fly   387 EKVPSHTQPSRPPLPRSCSSAN-----SSSSLSNDGNIAGKSMSRTRRSYPCPLCHRPFGTRHNL 446
              :..|||    .|...|:...     ||..:.:..|..|:      :.:.|.||.|.|....:|
  Fly   386 --MRMHTQ----ELVYQCAICREAFRASSELVQHMKNHMGE------KPFTCSLCDRSFTQSGSL 438

  Fly   447 KRHYMIHTGEKPFSCSKCRKPFRECSTLKKHMVTHVRDRWYKCLRCPSKFRDYLEYSDHKNNHQD 511
            ..|..||||||||.|..|.|.|.:.|:|..||..|..::.|.|..|...:......:.|...|
  Fly   439 NIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAH-- 501

  Fly   512 QLSSRKSSIYESDDDG---DSSVEDCLECCECQQRFTELDAYTAHLKKHDLELY----------- 562
            |::|..|:   |...|   .....:.|.|..|.....:..|..:|:......|.
  Fly   502 QMASAASA---STSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTA 563

  Fly   563 -GMSIDDV---ADEEQDDVD 578
             |.:|.||   |:|:|..|:
  Fly   564 PGGAIPDVKCSAEEQQAYVE 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523	5/21 (24%)
		C2H2 Zn finger	247..267	CDD:275368	5/19 (26%)
		zf-H2C2_2	259..282	CDD:290200	10/22 (45%)
		C2H2 Zn finger	275..295	CDD:275368	8/19 (42%)
		zf-C2H2	431..453	CDD:278523	7/21 (33%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		zf-H2C2_2	445..468	CDD:290200	13/22 (59%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	489..510	CDD:275368	3/20 (15%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	43/217 (20%)
		C2H2 Zn finger	256..276	CDD:275368	3/19 (16%)
		zf-H2C2_2	268..293	CDD:290200	4/24 (17%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		zf-H2C2_2	296..321	CDD:290200	11/24 (46%)
		zf-C2H2_2	312..>387	CDD:289522	23/129 (18%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	3/19 (16%)
		C2H2 Zn finger	369..389	CDD:275368	7/72 (10%)
		C2H2 Zn finger	397..417	CDD:275368	3/19 (16%)
		zf-H2C2_2	409..434	CDD:290200	7/30 (23%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	7/24 (29%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100