DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU1 and AT4G32060

DIOPT Version :9

Sequence 1:	NP_001097110.1	Gene:	MICU1 / 33999	FlyBaseID:	FBgn0031893	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_194934.1	Gene:	AT4G32060 / 829337	AraportID:	AT4G32060	Length:	498	Species:	Arabidopsis thaliana

Alignment Length:	368	Identity:	114/368 - (30%)
Similarity:	183/368 - (49%)	Gaps:	21/368 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 FRERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMTPGMKQPDGLGLDQ 222
            :|.:....||.|:|..|.|:|||.|||:::.    |:.|:.|.|.|.:.::.|.....:...:.:
plant   138 YRRKIFFNYEKRLRLQSPPEKVFEYFASVRT----DKGEILMKPADLMRAIVPVFPPSESHLVRE 198

  Fly   223 YRRYDPKSVGEQLNLHLEKNSIF--YKLGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGD 285
            ......::.||   |....:..|  :.:.:.|||:|.:|||.:|:|||....|.:||:|||.:.:
plant   199 GYLTGERNPGE---LRCSPSEFFMLFDVDNDGLISFKEYIFFVTLLSIPESSFAVAFKMFDTDNN 260

  Fly   286 GDVDCEEFEMVATLVRQQTSMGTRHRDHANTGNTFKG--VNSALITYFFGPNMDEKLTIEKFLDF 348
            |::|.|||:.|.:|:|.|...|..|||...||....|  .:..|:.||||.:..:||..:||..|
plant   261 GEIDKEEFKTVMSLMRSQHRQGVGHRDGLRTGLHMTGSVEDGGLVEYFFGKDGSQKLKHDKFTKF 325

  Fly   349 QEQLQREILSLEFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKR-----RFRDHGK 408
            .:.|..|:|.|||...:....|:|:..|||..::|.|  ......|.|.||:.     ..||  .
plant   326 MKDLTEEMLRLEFAHYDYKRRGSISAKDFALSMVAAA--DASHLSKLLDRVESLSEHPHLRD--M 386

  Fly   409 GISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDE 473
            .||.:::..|....:.:.....||..|..|...:..:..:..|..|..:.|||:|:::.|.:||.
plant   387 RISLKEFKQFDELRSKLGPFSLALFAYGKANGLLTMKDFKRAASQVCGITLSDNVIEIAFHVFDS 451

  Fly   474 NNDNQLSNKEFISVMKNRVQRGLEKPKDTGFLKMMRSVFKCAK 516
            |.|..||..||:.|:..| :|.:.:|...|..:.....:|.:|
plant   452 NQDGNLSVDEFLRVLHRR-ERDVAQPIAKGLSRYFSDGWKGSK 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh	<252..293	CDD:298682	20/40 (50%)
MICU1	NP_001097110.1	EF-hand_8	438..491	CDD:290545	17/52 (33%)
AT4G32060	NP_194934.1	EFh	216..273	CDD:238008	24/56 (43%)
		EFh_MICU	248..469	CDD:320080	74/224 (33%)
		EF-hand motif	248..276	CDD:320080	13/27 (48%)
		EF-hand motif	303..333	CDD:320080	11/29 (38%)
		EF-hand motif	404..433	CDD:320080	5/28 (18%)
		EF-hand motif	441..469	CDD:320080	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	55	1.000	Domainoid score	I4120
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4431
Inparanoid	1	1.050	172	1.000	Inparanoid score	I1523
OMA	1	1.010	-	-		QHG54184
OrthoDB	1	1.010	-	-		D707988at2759
OrthoFinder	1	1.000	-	-		FOG0005802
OrthoInspector	1	1.000	-	-		otm3233
orthoMCL	1	0.900	-	-		OOG6_103708
Panther	1	1.100	-	-	O	PTHR12294
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840