DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU1 and Micu3

DIOPT Version :9

Sequence 1:	NP_001097110.1	Gene:	MICU1 / 33999	FlyBaseID:	FBgn0031893	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_084386.1	Gene:	Micu3 / 78506	MGIID:	1925756	Length:	523	Species:	Mus musculus

Alignment Length:	500	Identity:	128/500 - (25%)
Similarity:	203/500 - (40%)	Gaps:	127/500 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 WGKVKRMLTPKVDADAGQRPSSAADVNGEDKSSESE--SEDSEDEEAGSDL----------HLHE 148
            ||:    |:....|..|........:.|:.::..||  :.:.||...|..|          .:..
Mouse    63 WGE----LSIAAAAGGGLVGLVCYQLYGDPRADPSELAAPELEDPPRGRGLLPIPVAAAKETVAT 123

  Fly   149 GKKIREKVGF----RERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMT 209
            |:.|.|.:..    |||:                 ||.||:|:.     ..:::|||.||:.::|
Mouse   124 GRAITEDLDLYATSRERR-----------------FRLFASIEC-----EGQLFMTPYDFILAVT 166

  Fly   210 PGMKQPDGLGLDQYRRYDP------KSVGEQ-LNLHLEK--------NSIFYKLGSYGLITFSDY 259
            ..               :|      ||:.:| |:..|.:        :.:|..|...|:|::::|
Mouse   167 TD---------------EPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEY 216

  Fly   260 IFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMVATLVRQQTSMGTRHRD------------ 312
            :|||.:|:.....|.|||.|||.:|:..||.:||.::..:.|::........|
Mouse   217 LFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLY 281

  Fly   313 --HANTGNTFKG-------------------------------------VNSALITYFFGPNMDE 338
              |:.|.:..|.                                     .::.|:.:|||.....
Mouse   282 GYHSPTNSVLKTDAGELVSRSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKA 346

  Fly   339 KLTIEKFLDFQEQLQREILSLEFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRF 403
            :|..|.|..|.:.||.|:|.:|| ....|....|:|.|||.:||.|..  ::.....|:.|:...
Mouse   347 ELNFEDFYRFMDNLQTEVLEIEF-LSYSNGMNTISEEDFAHILLRYTN--VENTSVFLENVRYSI 408

  Fly   404 RDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVF 468
            .:. |||:..::..||.||||:.|...||..|:.|..||.|...:........:.||.|:|:.||
Mouse   409 SEE-KGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVF 472

  Fly   469 TIFDENNDNQLSNKEFISVMKNRVQRGLEKPKDTGFLKMMRSVFK 513
            .|||.:.|:|||.||||.:||:|:.||....|........:|..|
Mouse   473 KIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh	<252..293	CDD:298682	17/40 (43%)
MICU1	NP_001097110.1	EF-hand_8	438..491	CDD:290545	23/52 (44%)
Micu3	NP_084386.1	DUF835	<349..437	CDD:283432	31/91 (34%)
Micu3	NP_084386.1	EF-hand_8	442..495	CDD:290545	23/52 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810