DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU1 and micu1

DIOPT Version :9

Sequence 1:	NP_001097110.1	Gene:	MICU1 / 33999	FlyBaseID:	FBgn0031893	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_005156578.1	Gene:	micu1 / 561210	ZFINID:	ZDB-GENE-070410-22	Length:	491	Species:	Danio rerio

Alignment Length:	484	Identity:	238/484 - (49%)
Similarity:	320/484 - (66%)	Gaps:	58/484 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LTKSSANLSLMQTRGHKRFG----HQEEKTPSVTKYFHMFILSLFLISVMDWGKVKRMLTPKVDA 109
            :|..||:..||.||.:...|    |:|:                           .|...|..|.
Zfish    42 VTGISASAGLMWTRAYAEAGSSVKHEEQ---------------------------MREEEPLKDV 79

  Fly   110 DAGQRPSSAADVNGEDKSSESESEDSEDEEAGSDLHLHEGKKIREKVGFRERKIIEYENRIRQFS 174
                  :..|:.:|..:||..|.||    ||||     |.||.::::|||:||::|||||||.:|
Zfish    80 ------AEEAESDGALESSSGEDED----EAGS-----EEKKKKQRIGFRDRKVMEYENRIRAYS 129

  Fly   175 TPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMTPGMKQPDGLGLDQY--RRYDPK------SV 231
            ||||:||||||:::.......||||||.||:.|:||..|||:.|||||:  :|||.|      .:
Zfish   130 TPDKIFRYFATLKIINEHGDAEVYMTPQDFVRSITPNEKQPENLGLDQFMVKRYDGKDFWQTEKI 194

  Fly   232 GEQLNLHLEKNSIFYKLGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMV 296
            .:......:::||||.||..|||:|||||||.||||..:|:|||||:||||||||:||.||||.|
Zfish   195 SQDREKFADEDSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDLEEFEQV 259

  Fly   297 ATLVRQQTSMGTRHRDHANTGNTFK--GVNSALITYFFGPNMDEKLTIEKFLDFQEQLQREILSL 359
            .:::|.|||||.||||.:.||||.|  |.:|||.|||||.::..||||..||:||.:||.::|.|
Zfish   260 QSIIRSQTSMGMRHRDRSTTGNTLKTGGCSSALTTYFFGADLKGKLTISSFLEFQRKLQHDVLKL 324

  Fly   360 EFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRFRDHGKGISKQDYLDFFHFLNN 424
            ||||.:|.| |.|||..|..:||||:|...:|.::..|.:||.|:| .:||:.::..:||.||.|
Zfish   325 EFERNDPVD-GRITEKQFGGMLLAYSGVQSRKLKQMQKNLKRMFKD-AQGITFEEVENFFTFLKN 387

  Fly   425 INDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSNKEFISVMK 489
            :|||||||:|||:||||||:.|::.||:|||.|.|||||.||||.:||.:.:.:|||||||::||
Zfish   388 VNDVDTALSFYHMAGASIDKATMKQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFIAIMK 452

  Fly   490 NRVQRGLEKPKDTGFLKMMRSVFKCAKET 518
            .|:.||||||||.||.:::|:::|||::|
Zfish   453 QRLMRGLEKPKDMGFTRLVRAMWKCAQDT 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh	<252..293	CDD:298682	31/40 (78%)
MICU1	NP_001097110.1	EF-hand_8	438..491	CDD:290545	33/52 (63%)
micu1	XP_005156578.1	PTPRCAP	29..>110	CDD:292341	27/109 (25%)
		EF-hand_5	236..259	CDD:289945	19/22 (86%)
		EF-hand_8	401..454	CDD:290545	33/52 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586387
Domainoid	1	1.000	156	1.000	Domainoid score	I4165
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4431
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1660
OMA	1	1.010	-	-		QHG54184
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	1	1.000	-	-		FOG0005802
OrthoInspector	1	1.000	-	-		oto39830
orthoMCL	1	0.900	-	-		OOG6_103708
Panther	1	1.100	-	-	LDO	PTHR12294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770