DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MICU1 and MICU3

DIOPT Version :9

Sequence 1:	NP_001097110.1	Gene:	MICU1 / 33999	FlyBaseID:	FBgn0031893	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001262741.1	Gene:	MICU3 / 42357	FlyBaseID:	FBgn0038735	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	133/486 - (27%)
Similarity:	205/486 - (42%)	Gaps:	138/486 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 KVKRMLTPKVDADAGQRPSSAADVNGEDKSSESE----------SEDSEDEEAGSDLHLHEGKKI 152
            |.:|:|| .|...|....:.||.:  :.:|:|:.          .:|||.|..
  Fly    46 KTRRLLT-IVGGSAVSLAALAAFI--KLRSAENPVNAVSLKRRMRDDSELENV------------ 95

  Fly   153 REKVGFRERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMT-----PGM 212
              |:..|||:.|:                 ||:::.   ||  ::||||.|||.|:.     |.:
  Fly    96 --KLTARERRFIK-----------------FASVEY---DD--QLYMTPQDFLDSVVEQEPRPRL 136

  Fly   213 K--QPDGLGLDQYRRYDPKSVGEQLNLHLEKNS--IFYKLGSYGLITFSDYIFLLTVLSISRRHF 273
            |  |.....:|:|:...|.         |:|.|  :|..|...|::::::|:|||::|:..:..|
  Fly   137 KRRQLSSDEVDKYKENTPA---------LKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKPKSGF 192

  Fly   274 EIAFRMFDLNGDGDVDCEEF-----------------------------------EMVATLVRQQ 303
            .|||.|||.:|:..||.:||                                   :|...:...|
  Fly   193 RIAFNMFDTDGNQRVDKDEFLVIISILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAVPQ 257

  Fly   304 TSMGTRHR---------------------------DHANTGNTFKG---VNSALITYFFGPNMDE 338
            ...|...|                           ::.|.|...:.   |.:.|..:|||.....
  Fly   258 AKRGIMERIFSGAWKEKHGEQEPEEELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGKRGTG 322

  Fly   339 KLTIEKFLDFQEQLQREILSLEFERKEPNDEGN--ITEADFAELLLAYAGYPLKKKQKKLKRVKR 401
            .:..:.|..|.:.||.|:|.|||..   ..:||  |:|.|||::||.|......:....|:|:..
  Fly   323 VINYDNFYRFMDNLQTEVLELEFHE---FSKGNSVISELDFAKILLRYTYLATDEYDVFLERLLE 384

  Fly   402 RFRDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDV 466
            |.:|. ||||..|:.||.|||||::|...|:..|.:|..:|.:.......|......||.|::|.
  Fly   385 RVKDE-KGISFHDFRDFCHFLNNLDDFTIAMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDT 448

  Fly   467 VFTIFDENNDNQLSNKEFISVMKNRVQRGLE 497
            ||.|||.:.|..||.||||::||:|:.||.:
  Fly   449 VFAIFDADGDGLLSYKEFIAIMKDRLHRGFK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh	<252..293	CDD:298682	16/40 (40%)
MICU1	NP_001097110.1	EF-hand_8	438..491	CDD:290545	21/52 (40%)
MICU3	NP_001262741.1	EF-hand_7	421..470	CDD:290234	18/48 (38%)
MICU3	NP_001262741.1	EF-hand_8	424..473	CDD:290545	20/48 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38732at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850