DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU1 and MICU2

DIOPT Version :9

Sequence 1:	NP_001097110.1	Gene:	MICU1 / 33999	FlyBaseID:	FBgn0031893	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_689939.1	Gene:	MICU2 / 221154	HGNCID:	31830	Length:	434	Species:	Homo sapiens

Alignment Length:	464	Identity:	123/464 - (26%)
Similarity:	201/464 - (43%)	Gaps:	97/464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 VMDW-GKVKRMLTPKVDADAGQRPSSAADVNGEDKSSESESEDSEDEEAGSDLHLHEGKKIREKV 156
            |..| ||::|.|.....|.....|.:|| |.|...:.           ||:..| |....:..:.
Human    11 VAAWGGKLRRGLAVSRQAVRSPGPLAAA-VAGAALAG-----------AGAAWH-HSRVSVAARD 62

  Fly   157 G---FRERKIIEY-----------ENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTS 207
            |   ...:|.:|:           :.|..|||:               .:...|.||||.|||.|
Human    63 GSFTVSAQKNVEHGIIYIGKPSLRKQRFMQFSS---------------LEHEGEYYMTPRDFLFS 112

  Fly   208 -MTPGMKQPDGLGLDQYRRYDPKSVGEQLNLHLEK----NSIFYKLGSYGLITFSDYIFLLTVLS 267
             |...|::...:     ::...|.:.:.|: .::.    ::.|..||..|||::::|:||||:|:
Human   113 VMFEQMERKTSV-----KKLTKKDIEDTLS-GIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILT 171

  Fly   268 ISRRHFEIAFRMFDLNGDGDVDCEEFEMVATLVRQQTSMGTRHRDHANTGNTFKG---------- 322
            .....|.:||:|.|.:|:..::..||..:..::.:|..:.|     ..|..|  |
Human   172 KPHSGFHVAFKMLDTDGNEMIEKREFFKLQKIISKQDDLMT-----VKTNET--GYQEAIVKEPE 229

  Fly   323 VNSALITYFFGPNMDEKLTIEKFLDFQEQLQREILSLE---------FERKEPNDEGNITEADFA 378
            :|:.|...|||.....||..::|..|.|.||.||..:|         |.|||          |||
Human   230 INTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSFMRKE----------DFA 284

  Fly   379 ELLLAYAGYPLKKKQKKLKRVKRRFRDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASID 443
            |.||.:..  .:.|....|.|:.:. ..|:.||..::..|.||..::.|...|:..:.:|...:.
Human   285 EWLLFFTN--TENKDIYWKNVREKL-SAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVR 346

  Fly   444 QQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSNKEFISVMKNRVQRGLEKPKDTGFLKMM 508
            ....:...|......||::::|.||.|||.:.|..||::||:.|:|||:.|||..|:.    :.:
Human   347 LAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQH----QSI 407

  Fly   509 RSVFKCAKE 517
            :..:||.|:
Human   408 QEYWKCVKK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh	<252..293	CDD:298682	15/40 (38%)
MICU1	NP_001097110.1	EF-hand_8	438..491	CDD:290545	17/52 (33%)
MICU2	NP_689939.1	EFh_MICU2	176..395	CDD:320082	67/238 (28%)
		EF-hand motif	176..205	CDD:320082	8/28 (29%)
		EF-hand motif	233..263	CDD:320082	11/29 (38%)
		EF-hand motif	329..358	CDD:320082	4/28 (14%)
		EF-hand motif	366..395	CDD:320082	14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54184
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830