Protein Alignment MICU1 and micu-1

DIOPT Version :10

• Sequence 1: NP_001097110.1
• Gene: MICU1 / 33999
• FlyBaseID: FBgn0031893
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001255723.1
• Gene: micu-1 / 178287
• WormBaseID: WBGene00013462
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 546
• Identity: 223/546 - (40%)
• Similarity: 328/546 - (60%)
• Gaps: 58/546 - (10%)

  Fly     2 SVLRFLVTRQALAALTRPRTLNIIQNPAQIAYASTLCNQNSNHNAKDLTKSSANLSLMQTR---- 62
            |.||.:..:.|...|...|:|.  ..||:.:.|..  .|:|..|.....|.:|..::.|.:
 Worm     5 SFLRVIPIKNASKRLIIVRSLT--SAPAKTSEAEK--QQDSLKNIDAGEKYTALGNIRQKKDVFH 65

  Fly    63 --------GHKRFG-----HQEEKTPSVTKYFH---MFILS--LFLISVMDWGK--VKRMLTPKV 107
                    |:..:.     |:....|.:.|.:|   ..:::  :.|:|..:|.|  :|....|
 Worm    66 YTDRASGVGYSHYSSSVYQHRPYIWPPLRKLYHWNYALVIAGMVILMSDFEWLKDQIKSASLP-- 128

  Fly   108 DADAGQRPSSAADVNGEDKSSESESEDSEDEEAGSDLHLHEGKKIREKVGFRERKIIEYENRIRQ 172
                 .||    :.:.:::.:||..|..|.:|          |..::|:|||||:|||||:|:|.
 Worm   129 -----FRP----EASQKEEVTESNGEVEEVKE----------KPKKKKLGFRERRIIEYEDRLRL 174

  Fly   173 FSTPDKVFRYFATIQV--PVADD-RHEVYMTPTDFLTSMTPGMKQPDGLGLDQYRRYDPKSVGEQ 234
            :|||||:||||||:::  |..|. |.||:|||.|||.|.|||:.||...|||.::.|:|:.  .:
 Worm   175 YSTPDKIFRYFATLKIIDPNEDSGRFEVFMTPEDFLRSFTPGVMQPRRWGLDSFKNYNPEK--HK 237

  Fly   235 LNLHLEKNSIFYKLGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMVATL 299
            .:...:.:|||||||..|||.||||:||:|:||.|...|.:||::||::|:|.:|.|||..|..|
 Worm   238 RHKFSDPDSIFYKLGENGLINFSDYLFLMTLLSTSHADFALAFKIFDVDGNGALDKEEFTKVQQL 302

  Fly   300 VRQQTSMGTRHRDHANTGNTFK-GVNSALITYFFGPNMDEKLTIEKFLDFQEQLQREILSLEFER 363
            :..||::|.|||||.....:|: ..||||.|||||.:....|:.|||::|||:||.:||.:||||
 Worm   303 IMSQTTVGQRHRDHITPNQSFRVETNSALETYFFGKDGKGSLSSEKFIEFQERLQHDILKMEFER 367

  Fly   364 KE--PNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRFR-DHGKGISKQDYLDFFHFLNNI 425
            ::  .|.:|.|.|..||:|||.:|....||::..||||||||: ::.||||..:...||.||.:|
 Worm   368 RDALDNPDGLINEDSFAQLLLLHAQINEKKQKHMLKRVKRRFKGENLKGISFGETKAFFEFLYHI 432

  Fly   426 NDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSNKEFISVMKN 490
            :|||.||.|:.:||.|||.:.||.||..|..:.|||||||||.|:||:|.|.:||::|.::||:.
 Worm   433 DDVDIALHFHKMAGMSIDAKLLQRVAVKVTGIPLSDHVVDVVITLFDDNLDGKLSHEEMVAVMRR 497

  Fly   491 RVQRGLEKPKDTGFLKMMRSVFKCAK 516
            |::||||:|:|||..::..:|.:|.|
 Worm   498 RMRRGLERPRDTGLFRLFDAVLECGK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh_MICU	272..492	CDD:320080	110/223 (49%)
		EF-hand motif	272..301	CDD:320080	13/28 (46%)
		EF-hand motif	326..425	CDD:320080	50/101 (50%)
		EF-hand motif	426..455	CDD:320080	15/28 (54%)
		EF-hand motif	463..492	CDD:320080	15/28 (54%)
micu-1	NP_001255723.1	EFh_MICU	275..494	CDD:320080	108/218 (50%)
		EF-hand motif	275..304	CDD:320080	13/28 (46%)
		EF-hand motif	330..432	CDD:320080	50/101 (50%)
		EF-hand motif	433..462	CDD:320080	15/28 (54%)
		EF-hand motif	470..494	CDD:320080	13/23 (57%)